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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Additionally we are shipping COL2 Antibodies (189) and COL2 Proteins (11) and many more products for this protein.
Showing 10 out of 52 products:
Human COL2 ELISA Kit for Sandwich ELISA - ABIN415072
Li, Liang, Tao, Zhou, Li, Chen, Chen: Acidic pH conditions mimicking degenerative intervertebral discs impair the survival and biological behavior of human adipose-derived mesenchymal stem cells. in Experimental biology and medicine (Maywood, N.J.) 2012
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Rat (Rattus) COL2 ELISA Kit for Sandwich ELISA - ABIN431583
Zhang, Yang, Li, Liu, Wu, Wang: Expression and significance of telomerase in the nucleus pulposus tissues of degenerative lumbar discs. in Biomedical reports 2015
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Human COL2 ELISA Kit for Sandwich ELISA - ABIN366754
Frisch, Rey-Rico, Venkatesan, Schmitt, Madry, Cucchiarini: Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I. in Tissue engineering. Part A 2015
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Rabbit COL2 ELISA Kit for Competition ELISA - ABIN774645
Ding, Zhu, Xu, Zhang, Zhao, Ji, Wang, Wang, Li, Kong, Ma, Yang: Integrated trilayered silk fibroin scaffold for osteochondral differentiation of adipose-derived stem cells. in ACS applied materials & interfaces 2014
Rabbit COL2 ELISA Kit for Sandwich ELISA - ABIN2014325
Wang, Jiang, Zhang, Huang, Qi, Wang, Zhang, Yu: Chondrogenic Potential of Peripheral Blood Derived Mesenchymal Stem Cells Seeded on Demineralized Cancellous Bone Scaffolds. in Scientific reports 2016
Rat (Rattus) COL2 ELISA Kit for Sandwich ELISA - ABIN368060
Liu, Huang, Chen, Zhang, Li, Wang, Ge, Wang, Zhang: Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase ?1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling. in The international journal of biochemistry & cell biology 2015
Mouse (Murine) COL2 ELISA Kit for Sandwich ELISA - ABIN367800
Tanner, Blundell, Colgrave, Howitt: Quantification of Hordeins by ELISA: the correct standard makes a magnitude of difference. in PLoS ONE 2013
This study proved that Berberine (BBR) is a direct thrombin (show F2 ELISA Kits) inhibitor that has activity in inhibiting thrombin (show F2 ELISA Kits)-induced platelet aggregation. BBR may be a potential candidate for the development of safe and effective thrombin (show F2 ELISA Kits)-inhibiting drugs
Thrombin (show F2 ELISA Kits) generation had a limited impact as biomarker of venous thromboembolism.
Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor (show F7 ELISA Kits) defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.
Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.
digestion of thrombin (show F2 ELISA Kits) by P. aeruginosa elastase leads to the release of the C-terminal thrombin (show F2 ELISA Kits)-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin (show F2 ELISA Kits) gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (show AGT ELISA Kits)), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 ELISA Kits)), and prothrombin (show F2 ELISA Kits) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (show SERPINC1 ELISA Kits) inhibition.
These results suggested that the thrombinstimulated synthesis of IL6 (show IL6 ELISA Kits) was limited by HSP90 (show HSP90 ELISA Kits) in osteoblasts, and that the effects of HSP90 (show HSP90 ELISA Kits) were exerted at the point between Rhokinase and p38 MAPK (show MAPK14 ELISA Kits).
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (show F2 ELISA Kits) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin (show F2 ELISA Kits)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (show F2 ELISA Kits) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN ELISA Kits) plays a protective role during the progression of atherosclerosis in ApoE (show APOE ELISA Kits)-deficient mice by inhibiting thrombin (show F2 ELISA Kits) generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA ELISA Kits)-binding and heparin-binding site of thrombin (show F2 ELISA Kits)
thrombin (show F2 ELISA Kits)/PAR-1 interaction regulated MCP-1 (show CPT1B ELISA Kits), TF, MCSF (show CSF1 ELISA Kits) and IL-6 (show IL6 ELISA Kits) production.
Observations illustrate the role of thrombin (show F2 ELISA Kits) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 ELISA Kits) nanoparticle therapeutics.
Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
the weaker rapid interaction between prothrombin (show F2 ELISA Kits) and membranes is the most important in vivo when considering the activation of prothrombin (show F2 ELISA Kits) at the cell surface.
novel pyranosic sulfated (show SULF1 ELISA Kits) arabinan Ab1 exerts its anticoagulant activity on thrombin (show F2 ELISA Kits) by a mechanism different from those found previously for other sulfated (show SULF1 ELISA Kits) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin (show F2 ELISA Kits) enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (show MAPK1 ELISA Kits), MSK1 (show RPS6KA5 ELISA Kits), and NF-kappaB (show NFKB1 ELISA Kits) play important roles in thrombin (show F2 ELISA Kits)-induced iNOS (show NOS2 ELISA Kits) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin (show F2 ELISA Kits) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R ELISA Kits)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 ELISA Kits)+).
kinetic and structural analysis of interactions between thrombin (show F2 ELISA Kits) and the Factor XIII (show UGDH ELISA Kits) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin (show F2 ELISA Kits) activation
thrombin (show F2 ELISA Kits) and factor Xa (show F10 ELISA Kits) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin (show F2 ELISA Kits) to bovine thrombin (show F2 ELISA Kits) as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2