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In mouse, there are two classes of high-affinity IL3 receptors. Additionally we are shipping CSF2RB2 Kits (6) and CSF2RB2 Proteins (3) and many more products for this protein.
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The beta chain cytokine receptor Csf2rb2 was identified as a downstream molecule of Notch signaling in hematopoietic cells.
Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
this receptor adopts an arch-like intertwined homodimeric structure
the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling
Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms.
IL-3-driven survival and proliferation is negatively regulated, potentially via tyrosine phosphorylation of Aic2A and STAT5
Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts.
In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.
IL-3 receptor class 2 subunit beta
, IL-3R class 2 subunit beta
, colony-stimulating factor 2 receptor subunit beta-2
, interleukin-3 receptor class 2 subunit beta
, interleukin-3 receptor class II beta chain