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Might be involved in complement regulation. Additionally we are shipping Complement Factor H-Related 2 Antibodies (32) and Complement Factor H-Related 2 Proteins (7) and many more products for this protein.
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Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis.
Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2]
Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.
Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.
Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I.
A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay.
Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
, H factor (complement)-like 3
, complement factor H-related protein 2
, factor H-related gene 2
, h factor-like 3
, h factor-like protein 2