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The protein encoded by CFHR3 is a secreted protein, which belongs to the complement factor H-related protein family. Additionally we are shipping CFHR3 Kits (8) and and many more products for this protein.
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To our knowledge, this is the first evaluation of the involvement of the CFHR3/CFHR1 (show CFHR1 Antibodies) deletion and age-related macular degeneration in CFH (show CFH Antibodies) Y402H polymorphism Brazilian patients.
These data provide evidence that FHR3, which is absent in patients with the autoimmune form of hemolytic uremic syndrome, is involved in B cell regulation
We describe a novel CFH (show CFH Antibodies)/CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H (show CFH Antibodies) and exhibits impaired cell surface complement regulation
Next-generation sequencing of the CFH (show CFH Antibodies) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH Antibodies)-related genes in the retina or RPE (show RPE Antibodies)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins.[CFHR3]
Studies indicate that complement factor H (show CFH Antibodies)-related proteins (FHR1 (show CFHR1 Antibodies)-5) may enhance complement activation, with important implications for the role of these proteins in disease.
These results suggest that the combination of quantitative and qualitative variations in the complement proteins encoded by CFH (show CFH Antibodies), CFHR3 and CFHR1 (show CFHR1 Antibodies) genes is key for the association of these haplotypes with disease.
Genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby predispose patients to develop IgA nephropathy.
Prompt use of immunosuppressive agents and plasma exchanges are useful for improving outcomes in pediatric patients with anti-complement factor H (show CFH Antibodies)-associated HUS (show CFH Antibodies).
Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH (show CFH Antibodies)/CFHR1 (show CFHR1 Antibodies)-3 and complement factor H (show CFH Antibodies) 479.
we have assessed the relationship between GA and previously identified AMD (show AMD1 Antibodies)-associated variants of genes (CFH (show CFH Antibodies), CFB (show CFB Antibodies), C3, FHR1 (show CFHR1 Antibodies), FRH3, and ARMS2 (show ARMS2 Antibodies)/HTRA (show HTRA1 Antibodies)).
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
H factor-like 4
, H factor-like protein 3
, complement factor H-related protein 3