anti-Cone-Rod Homeobox (CRX) Antibodies

The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. Additionally we are shipping Cone-Rod Homeobox Proteins (10) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRX 1406 O43186
CRX 60446  
CRX 12951 O54751
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Top anti-Cone-Rod Homeobox Antibodies at

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated ELISA, WB CRX monoclonal antibody (M02), clone 4G11 Western Blot analysis of CRX expression in IMR-32 . Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M02), clone 4G11.Lane 1: CRX transfected lysate(32 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
Human Goat Un-conjugated ELISA, IHC, WB ABIN1590000 (1 µg/mL) staining of Rat Retina lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Human Rabbit Un-conjugated WB Western blot analysis of CORD2 using anti-CORD2 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: HEPG2 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CORD2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CORD2 at approximately 37KD. The expected band size for CORD2 is at 32KD. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated WB Host: Rabbit Target Name: CRX Sample Type: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Anti-CRX1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Human Mouse Un-conjugated RNAi, ELISA, WB Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M01), clone F6-C2.Lane 1: CRX transfected lysate(32.261 KDa).Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged CRX is approximately 1ng/ml as a capture antibody. 100 μg 11 to 12 Days
Human Rabbit Un-conjugated WB Western blot analysis of lysate from Y79 cell line, using CRX Antibody at 1:1000. 400 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of mouse eye, using CRX antibody (ABIN5973349) at 1/1000 dilution. 100 μL 11 to 16 Days
Human Rabbit Alexa Fluor 647 IF (p)   100 μL 14 to 21 Days
Human Rabbit Alexa Fluor 350 IF (p)   100 μL 14 to 21 Days

Top referenced anti-Cone-Rod Homeobox Antibodies

  1. Human Monoclonal CRX Primary Antibody for ELISA, WB - ABIN560473 : Peng, Chen: Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. in Human molecular genetics 2007 (PubMed)
    Show all 10 Pubmed References

  2. Human Monoclonal CRX Primary Antibody for ELISA, WB - ABIN514613 : Terrell, Xie, Workman, Mahato, Zelhof, Gebelein, Cook: OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. in Developmental dynamics : an official publication of the American Association of Anatomists 2011 (PubMed)

  3. Human Monoclonal CRX Primary Antibody for RNAi, ELISA - ABIN560472 : Gong, Sagiv, Cai, Tsang, Del Priore: Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. in Experimental eye research 2008 (PubMed)

  4. Human Polyclonal CRX Primary Antibody for IF (p), IHC (p) - ABIN704276 : Machalińska, Rogińska, Pius-Sadowska, Kawa, Paczkowska, Rudnicki, Lejkowska, Baumert, Wiszniewska, Machaliński: Neuroprotective and antiapoptotic activity of lineage-negative bone marrow cells after intravitreal injection in a mouse model of acute retinal injury. in Stem cells international 2015 (PubMed)

More Antibodies against Cone-Rod Homeobox Interaction Partners

Zebrafish Cone-Rod Homeobox (CRX) interaction partners

  1. CRX can influence the development and opsin expression of photoreceptor outer segments in zebrafish.

  2. The CRX protein can recognize the BAT 1 regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.

  3. No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.

Human Cone-Rod Homeobox (CRX) interaction partners

  1. Study in Lebanese family with 3 affected individuals report for a first time a novel, complete homozygous 56,000 bp deletion of CRX in Leber congenital amaurosis.

  2. The five patients with bull's-eye maculopathy along with a negative ERG had differing genotypes. Mutations were found in the CRX gene (2 patients), the ABCA4 gene (1 patient), and the GUCY2D gene (2 patients).

  3. A heterozygous nonsense variant c.292C > T (p.R98X) of CRX gene was identified in a Chinese family with atypical and mild manifestations of Retinitis pigmentosa.

  4. Mutation in CRX gene is associated with macular dystrophy with intrafamilial variable expressivity.

  5. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup

  6. A novel CRX pathogenic variant has been identified in our patients. The novel pathogenic variant seems to have a different effect on the phenotype of cone-rod dystrophy.

  7. A sensitive and simple method of tumour cell assessment has been developed that can be used in the clinics to assess for potential extraocular dissemination after intravitreal injections to assure its performance.

  8. we revealed a novel frameshift mutation (NM_000554.4:c.538dupG:p.Val180fs) in exon 4 of the CRX gene in a Chinese family with Cone-rod dystrophy. This study broadens the known pathogenic mutation spectrum of the CRX gene and contributes to improved genetic counseling for Cone-rod dystrophy patients.

  9. analysis of a homozygous nonsense mutation in SAMD11 in five individuals diagnosed with adult-onset retinitis pigmentosa; SAMD11 interacts with CRX and is expressed in retina

  10. CRX mutations are associated with a variety of clinical phenotypes, including an adult-onset macular dystrophy that simulates benign concentric annular macular dystrophy with a bull's eye macular lesion and fairly well preserved visual acuity.

  11. data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.

  12. Loss of OTX2 expression resulted in decreased expression of C-MYC and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation

  13. Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.

  14. Con rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.

  15. Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.

  16. Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.

  17. CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors

  18. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.

  19. the potential utility of CRX as a marker of pineal lineage in routine diagnostic neuropathology.

  20. In this study, three variations were detected in 3 of 130 families with CORD, including two novel mutations, c.239A>G (p.Glu80Gly) and c.362C>T (p.Ala121Val)

Cow (Bovine) Cone-Rod Homeobox (CRX) interaction partners

  1. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium.

Mouse (Murine) Cone-Rod Homeobox (CRX) interaction partners

  1. CRX gene could induce the differentiation of Muller cell-derived progenitor into rod photoreceptors, indicating a new avenue to study muller cells as endogenous seed cells for retinal photoreceptor

  2. A Crx-dependent gene regulatory network was unraveled involving presynaptic genes that encode cytomatrix-associated proteins governing the organization of the photoreceptor ribbon synapse but not the formation of ribbon structure.

  3. Results demonstrate that the activity of CRX binding sites is highly dependent on sequence context, providing insight into photoreceptor gene regulation and illustrating functional principles of homeodomain binding sites that may be conserved in other cell types.

  4. CRX is required for chromatin remodeling at only a subset of its binding sites, which undergo retina or neuronal specific activation during photoreceptor differentiation.

  5. proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes.

  6. The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.

  7. CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.

  8. Rax and Crx cooperatively transactivate Rhodopsin and cone opsin promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.

  9. E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.

  10. The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis

  11. We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2.

  12. In Crx-knockout mice vasopressin mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.

  13. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.

  14. Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module

  15. Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue

  16. A change in the suprachiasmatic nuclei of the Crx-deficient mouse might explain the observed circadian differences between the knockout mouse and wild-type mouse.

  17. CRX combinatorially orchestrates the transcriptional networks of both rods and cones by coordinating the expression of photoreceptor genes including most retinal disease genes.

  18. Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.

  19. CRX has a role in retinal and pineal lineage tumors

  20. Crx is expressed very soon after a cell fated to be a photoreceptor cell becomes postmitotic.

Cone-Rod Homeobox (CRX) Antigen Profile

Protein Summary

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with anti-Cone-Rod Homeobox (CRX) Antibodies

  • cone-rod homeobox (crx) antibody
  • cone-rod homeobox (CRX) antibody
  • cone-rod homeobox (Crx) antibody
  • CORD2 antibody
  • CRD antibody
  • CRX antibody
  • Crx1 antibody
  • LCA7 antibody
  • OTX3 antibody
  • otx5 antibody
  • otx5b antibody
  • rx antibody
  • Xotx5 antibody
  • Xotx5b antibody

Protein level used designations for anti-Cone-Rod Homeobox (CRX) Antibodies

cone-rod homeobox , homeobox protein otx5 , orthodenticle homolog 5 , cone-rod homeobox protein , orthodenticle homeobox 3 , crx gene for cone-rod homeobox protein , photoreceptor-specific cone-rod homeobox protein , cone-rod homeobox containing

81881 Danio rerio
468934 Pan troglodytes
548775 Xenopus (Silurana) tropicalis
554246 Monodelphis domestica
717550 Macaca mulatta
100379624 Felis catus
1406 Homo sapiens
280756 Bos taurus
403577 Canis lupus familiaris
60446 Rattus norvegicus
12951 Mus musculus
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