anti-Contactin Associated Protein-Like 2 (CNTNAP2) Antibodies

CNTNAP2 encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. Additionally we are shipping CNTNAP2 Kits (12) and CNTNAP2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CNTNAP2 26047 Q9UHC6
CNTNAP2 66797 Q9CPW0
CNTNAP2 500105  
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Top anti-CNTNAP2 Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated IHC, WB IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of Contactin associated protein like 2 (CNTNAP2): whole serum  at 1 : 200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin. IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of Contactin associated protein like 2 (CNTNAP2): whole serum  at 1 : 200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin. 100 μL 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CNTNAP2 Antibody (Center) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Anti Caspr2 Polyclonal Antibody, Unconjugated (ABIN1386423) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CNTNAP2 Antibody in CEM cell line lysates (35ug/lane) Formalin-fixed and paraffin-embedded mouse brain tissue reacted with CNTNAP2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated   100 μg 2 to 3 Days
$280.57
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of CNTNAP2 transfected lysate using anti-CNTNAP2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with CNTNAP2 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of CNTNAP2 expression in transfected 293T cell line by CNTNAP2 MaxPab polyclonal antibody.Lane 1: CNTNAP2 transfected lysate(148.2 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Mouse Atto 633 IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain with CNTNAP2 monoclonal antibody, clone S67-25 . Western blot analysis of rat brain membrane tissues with CNTNAP2 monoclonal antibody, clone S67-25  at 1:1000 dilution. 100 μg 11 to 12 Days
$577.33
Details
Human Mouse Atto 488 IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain with CNTNAP2 monoclonal antibody, clone S67-25 . Western blot analysis of rat brain membrane tissues with CNTNAP2 monoclonal antibody, clone S67-25  at 1:1000 dilution. 100 μg 11 to 12 Days
$577.33
Details
Human Mouse APC IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain with CNTNAP2 monoclonal antibody, clone S67-25 . Western blot analysis of rat brain membrane tissues with CNTNAP2 monoclonal antibody, clone S67-25  at 1:1000 dilution. 100 μg 11 to 12 Days
$577.33
Details

Top referenced anti-CNTNAP2 Antibodies

  1. Mammalian Monoclonal CNTNAP2 Primary Antibody for ISt, IHC - ABIN1304572 : Varea, Martin-de-Saavedra, Kopeikina, Schürmann, Fleming, Fawcett-Patel, Bach, Jang, Peles, Kim, Penzes: Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. in Proceedings of the National Academy of Sciences of the United States of America 2015 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal CNTNAP2 Primary Antibody for - ABIN2017587 : Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. in Biochimica et biophysica acta 2015 (PubMed)

  3. Human Polyclonal CNTNAP2 Primary Antibody for IHC, IHC (p) - ABIN4288206 : Krumbiegel, Pasutto, Schlötzer-Schrehardt, Uebe, Zenkel, Mardin, Weisschuh, Paoli, Gramer, Becker, Ekici, Weber, Nürnberg, Kruse, Reis: Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome. in European journal of human genetics : EJHG 2011 (PubMed)

More Antibodies against CNTNAP2 Interaction Partners

Human Contactin Associated Protein-Like 2 (CNTNAP2) interaction partners

  1. Results support a role of CNTNAP2 in language-related phenotypes

  2. rs2107856 SNP of CNTNAP2 gene has no association with PXS and PXG in the evaluated Turkish population.

  3. The distribution of CNVs across CNTNAP2 in psychiatric cases from previous reports was no different from controls of the database of genomic variants. Gene-based association testing did not implicate common variants in autism, schizophrenia or other psychiatric phenotypes.

  4. CNTNAP2 gene has been found to be associated with language disorders and sequential learning and phonological buffer's performances. Mutations in CNTNAP2 have been associated with language impairments at a behavioral level as well as with changes in brain structure.

  5. Loss of one Cntnap2 allele is sufficient to elicit axonal growth alteration, revealing a situation that may be relevant for CNTNAP2 heterozygosity in autism spectrum disorder patients

  6. After adjustment for the false discovery rate (FDR), two SNPs (rs3779031, rs987456) of CNTNAP2 were associated with developmental dyslexia risk in females but not in males.

  7. Study screened 28 autosomal dominant epilepsy with auditory features (ADEAF) families for mutations in CNTNAP2 by next generation sequencing and copy number variation analyses and found no likely pathogenic mutations segregating with the disease. CNTNAP2 should be screened in genetically unsolved ADEAF families, but causative mutations are expected to be infrequent in this gene.

  8. This study evaluated a possible association between ASD and the presence of five single nucleotide polymorph-isms (rs7794745, rs10500171, rs2710105,rs2710102, and rs2538989 ) in CNTNAP2in the Korean population. The genetic variants in CNTNAP2 do not play a role in ASD affection possibility in this study, but evidence suggests that one SNP(rs10500171) might be associated with sociality-relatedphenotypes in Koreans

  9. In utero CASPR2-IgG exposed neonates achieved milestones similarly to healthy control-IgG exposed but, when adult, the CASPR2-IgG exposed progeny showed marked social interaction deficits, abnormally located glutamatergic neurons in layers V-VI of the somatosensory cortex, a 16% increase in activated microglia, and a 15-52% decrease in glutamatergic synapses in layers of the prefrontal and somatosensory cortices.

  10. the selective distribution of Caspr2 and TAG-1 may be regulated, allowing them to modulate the strategic function of the Kv1 complex along axons

  11. The clinical phenotypes of anti-LGI1 encephalitis and anti-Caspr2 encephalitis have been described in more detail including data on treatment and long-term follow-up. Lumping patients with anti-LGI1, anti-Caspr2 antibodies or lacking both, should be considered obsolete--{REVIEW}

  12. Subjects with greater left dorsolateral prefrontal cortex (DLPFC) surface area had better cognitive performance. Importantly, the left DLPFC surface area mediated the association between the CNTNAP2 rs4726946 genotype and cognitive performance. This study provides the first evidence for associations among the CNTNAP2 gene, left DLPFC structure, and cognitive control.

  13. associations of a common CNTNAP2 polymorphism (rs7794745) with variation in grey matter in a region in the dorsal visual stream

  14. Bi-allelic aberrations (mutations and copy number variants) in CNTNAP2 in eight individuals with intellectual disability and epilepsy were reported.

  15. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG.

  16. Caspr2 antibodies associate with a treatable disorder that predominantly affects elderly men. The resulting syndrome may vary among patients but it usually includes a set of well-established symptoms.

  17. The molecular shape and dimensions of CNTNAP2 place constraints on how CNTNAP2 integrates in the cleft of axo-glial and neuronal contact sites and how it functions as an organizing and adhesive molecule.

  18. A significant association was found between rs7794745 CNTNAP2 gene polymorphism and autism in an Iranian population.

  19. rs7794745 in the CNTNAP2 gene was associated with autistic spectrum disorder in Brazilian patients.

  20. we could not detect any significant association with the CNTNAP2 gene and high functioning autism

Mouse (Murine) Contactin Associated Protein-Like 2 (CNTNAP2) interaction partners

  1. This study demonstrated that cntnap2 knockout affect the neuronal pathway development in mice.

  2. Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity do to enhanced primary afferent excitability.

  3. This study show that homozygous mice lacking Cntnap2 exhibit reduced long-range and local functional connectivity in prefrontal cortical regions and midline functional hubs of the mouse brain.

  4. Performing cortical neuron cultures from mouse embryos, we demonstrate that Caspr2 plays a dose-dependent role in axon growth in vitro. Loss of one Cntnap2 allele is sufficient to elicit axonal growth alteration, revealing a situation that may be relevant for CNTNAP2 heterozygosity in ASD patients

  5. This study demonstrated an age-dependent effect of Cntnap2 deletion on both tonic and phasic inhibition in layer 2/3 pyramidal cells in the visual cortex.

  6. native medial prefrontal cortex parvalbumin neuronal activity differed between CNTNAP2 knockout and wild-type mice.

  7. Caspr2/Caspr1 double mutants results in muscle fiber degeneration accompanied by mitochondrial dysfunction.

  8. Cntnap2 KO rats exhibited severe motor seizures, hyperactivity, and increased consolidation of wakefulness and REM sleep. By contrast, Cntnap2 KO mice demonstrated absence seizure-like events, hypoactivity, and wake fragmentation.

  9. After middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor,contactin-associated protein 2 (Cntnap2).

  10. These findings suggest that contactin-associated-like-protein 2 may influence the development of neural systems important to learning and cross-modal integration, and that disruption of this function could be associated with delayed learning in autism spectrum disorder.

  11. Olfaction-based behavioral tests revealed that mice lacking Caspr2 exhibit abnormal response to sensory stimuli and lack preference for novel odors.

  12. Mice with the Cntnap2 genetic mutation showed a dissociation of auditory-processing abilities

  13. Study reports behavioral characterization of mouse models of autism with null mutation in Cntnap2 gene. It shows hyperactivity, mild gait phenotype and reduced vocalizations among others.

  14. new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry

  15. Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying autism spectrum disorders

  16. The CASPR2/MUPP1 receptor complex co-localized with GPR37 in hippocampal neurons.

  17. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).

  18. CNTNAP2 has a role in the correct trafficking of GluA1 AMPA-type glutamate receptors

  19. Caspr2 is required for paranodal clustering of Kv1 channels in the absence of Caspr. Absence of both Caspr and Caspr2 results in the widening of the nodes of Ranvier.

  20. two novel genes, Cntnap2 and Tag1, are implicated in the regulation of diet-induced obesity.

CNTNAP2 Antigen Profile

Protein Summary

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

Gene names and symbols associated with CNTNAP2

  • contactin associated protein like 2 (CNTNAP2) antibody
  • contactin associated protein-like 2 (Cntnap2) antibody
  • contactin associated protein-like 2 (CNTNAP2) antibody
  • contactin associated protein like 2b (cntnap2b) antibody
  • contactin associated protein like 2 (cntnap2) antibody
  • contactin associated protein like 2 (Cntnap2) antibody
  • 5430425M22Rik antibody
  • AUTS15 antibody
  • CASPR antibody
  • Caspr2 antibody
  • CDFE antibody
  • MGC145769 antibody
  • MGC147944 antibody
  • MGC147981 antibody
  • mKIAA0868 antibody
  • NRXN4 antibody
  • PTHSL1 antibody

Protein level used designations for CNTNAP2

cell recognition molecule Caspr2 , contactin-associated protein-like 2 , homolog of Drosophila neurexin IV , contactin associated protein-like 2 , novel protein similar to H.sapiens contactin associated protein , contactin associated protein 2 , contactin-associated protein-like 2-like

GENE ID SPECIES
26047 Homo sapiens
66797 Mus musculus
463819 Pan troglodytes
516395 Bos taurus
563345 Danio rerio
574172 Macaca mulatta
780189 Xenopus (Silurana) tropicalis
100174321 Pongo abelii
100013863 Monodelphis domestica
100060296 Equus caballus
100073864 Ornithorhynchus anatinus
100223892 Taeniopygia guttata
100354524 Oryctolagus cuniculus
100397041 Callithrix jacchus
100607262 Nomascus leucogenys
500105 Rattus norvegicus
100717858 Cavia porcellus
100687859 Canis lupus familiaris
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