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Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Additionally we are shipping Coordinator of PRMT5, Differentiation Stimulator Proteins (4) and Coordinator of PRMT5, Differentiation Stimulator Antibodies (3) and many more products for this protein.
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Data extend the role of COPR5 from an adaptor protein required for nuclear functions of PRMT5 to an essential coordinator of myogenic differentiation.
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity).
cooperator of PRMT5
, coordinator of PRMT5 and differentiation stimulator