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Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm.
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Results provide the first evidence of genetic variants in the CPNE5 gene influencing both alcohol dependence and obesity
Study generated Cpne5 KO mice model and found that Cpne5 deficiency did not affect rodent locomotor activity and memory, but significantly decrease rodent anxiety level in elevated plus maze and elevated platform tasks, which indicates the important role of Cpne5 in regulating anxiety level.
Our results demonstrate that CPNE5 is expressed in both neural progenitor cells and the differentiated neurons during the neural development, which suggests that CPNE5 might play an important role in the development of murine central nervous system.
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined.
, copine 5
, copine 5 protein