anti-Creatine Kinase, Muscle (CKM) Antibodies

The protein encoded by CKM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. Additionally we are shipping Creatine Kinase, Muscle Kits (148) and Creatine Kinase, Muscle Proteins (51) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CKM 1158 P06732
CKM 12715 P07310
CKM 24265 P00564
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Top anti-Creatine Kinase, Muscle Antibodies at antibodies-online.com

Showing 10 out of 376 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CKM Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Muscle Host:  Rabbit  Target Name:  CKM  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CKM Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart Host:  Mouse  Target Name:  CKM  Sample Tissue:  Mouse Small Intestine  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of Creatine Kinase M staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Creatine Kinase M staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from Jurkat/HeLa/HepG2/HuvEc cells, using M-CK Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart tissue, using M-CK Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from mouse lung, rat brain, using M-CK Antibody. ABIN6274151 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Heart lysate; ;Primary Ab: 2µg/ml Rabbit Anti-Human CKM Antibody;Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(Catalog: SAA544Rb19) 100 μg Log in to see 15 to 18 Days
$316.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Brain lysate; ;Primary Ab: 2µg/ml Rabbit Anti-Mouse CKM Antibody;Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(Catalog: SAA544Rb19) 100 μg Log in to see 15 to 18 Days
$324.00
Details
Dog Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Heart lysate; ;Primary Ab: 2µg/ml Rabbit Anti-Canine CKM Antibody;Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$360.00
Details

Top referenced anti-Creatine Kinase, Muscle Antibodies

  1. Human Monoclonal CKM Primary Antibody for WB - ABIN532707 : Newby: Markers of cardiac ischemia, injury, and inflammation. in Progress in cardiovascular diseases 2004 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CKM Primary Antibody for IF, IHC - ABIN6712349 : Chen, Zhao, Li, Gao, Meng, Yan, Zhou: Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin. in The Biochemical journal 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal CKM Primary Antibody for IF (p), IHC (p) - ABIN872835 : Rueda, Johnson, Giddabasappa, Swaroop, Brooks, Sigel, Chaney, Fox: The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. in Molecular vision 2016 (PubMed)

  4. Human Polyclonal CKM Primary Antibody for WB - ABIN630558 : Mihm, Yu, Reiser, Bauer: Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers. in Biochimie 2003 (PubMed)

  5. Human Monoclonal CKM Primary Antibody for - ABIN933705 : Wojciechowski, Chase-Baldwin, Wasieloski, Padilla, Vora, Taitt: Enhancement of deoxyribonucleic acid microarray performance using post-hybridization signal amplification. in Analytica chimica acta 2010 (PubMed)

More Antibodies against Creatine Kinase, Muscle Interaction Partners

Human Creatine Kinase, Muscle (CKM) interaction partners

  1. elevated CK-MB value is a common finding in RV-infection and completely mediated by the severity of diarrhea. CK-MB monitoring may help to identify children with more severe viral infection.

  2. The formation of insoluble aggregates would decrease levels of active Creatine kinase (CK) which may provide clues in CK deficiency disease. Moreover, these results indicated that the degree of synergism had closely relationship to the conformational changes of CK

  3. Low CK-MB expression is associated with ST-Segment Elevation Myocardial Infarction.

  4. On admission, high-sensitivity troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.

  5. A genetic factor known to be associated with constitutive creatine kinase levels is also associated with creatine kinase variability and inducibility and the variant has an impact on inducibility of creatine kinase by trauma through a homozygous carrier.

  6. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.

  7. Marathoners with a lower CKMM response after the race had a more favorable polygenic profile than runners with high serum CKMM concentrations. This might suggest a significant role of genetic polymorphisms in the levels of exertional muscle damage and rhabdomyolysis.

  8. Myocardial Creatine Kinase is a significant independent predictor of 6-month left ventricle remodeling in myocardial infarction patients.

  9. A positive association was found between PANSS-total and sCK [serum creatine kinase] in SzA [schizoaffective disorder] and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.

  10. These results demonstrate an association between physical performance measures and genetic variation in the muscle-specific creatine kinase gene (rs8111989).

  11. Muscle pain induced by simvastatin resulted in increased levels of creatine kinase compared to non-treated patients.

  12. Data show that a low serum creatine kinase activity is more common in female than male, and is associated with older age.

  13. CK-MB mass is more significant criteria of myocardial injury.

  14. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants

  15. CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups.

  16. The serum expression levels of myocardial creatine kinase and of galectin-3 reflect the physiopathology state of children with congenital heart defects after surgical correction.

  17. The variant rs11559024 in the CKM gene (Glu83Gly) was significantly associated with CK levels of statin users.

  18. elderly women classified as high response experienced greater serum response to eccentric resistance exercise

  19. Based on the obtained results, it may be speculated that the CKM A/G polymorphism is not an important determinant of endurance performance level in Polish and Russian rowers.

  20. Substantive creatine phosphokinase increases and rhabdomyolysis with statin use were particularly seen in patients starting treatment, those on large daily doses or interacting drugs or with larger numbers of concomitant drugs

Mouse (Murine) Creatine Kinase, Muscle (CKM) interaction partners

  1. We conclude that ILK negatively and independently of PI3K regulated MEF2C phosphorylation activity and MCK mRNA expression in C2C12 cells

  2. The Fxn KO/Mck mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills.

  3. PI3K and AKT regulated skeletal muscle differentiation by regulating the expression of Myogenin and MCK.

  4. CK-M overexpression led to significantly increased contractile function at baseline and during adrenergic stimulation and increased survival after thoracic aortic constriction-induced heart failure.

  5. strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin

  6. These studies indicate that the age-associated oxidative and nitrative modification of CKm results in a decrease in its activity and may cause structural changes that promote oligomerization and aggregation.

  7. Not involved in levels of creatine nnd creatine kinase in skeletal muscle of knockout mice.

  8. one of the consequences of M-CK and AK1 deficiency is hampered phosphoryl delivery to the actomyosin ATPase, resulting in a loss of contractile performance.

  9. Allosteric activation of phosphorylase b accounts for the accelerated glycogenolysis in CK-/- muscle during contraction.

  10. Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase enhancer

  11. the expression of muscle creatine kinase (MCK) gene in the heart and skeletal muscle of mice during aging

  12. metabolic failure induced by CK deficiency profoundly affects the ability of mice to engage in chronic bouts of endurance running exercise and that this decrease in performance is also associated with muscle wasting

  13. CK-MM autoantibodies can modulate the rate of CK clearance from the circulation in myositis

  14. Data show that spatial relations among organelles of muscle cells undergo adaptation in response to nonstructural stimuli such as metabolic (creatine kinase)deficiency.

  15. The creatine kinase energy transport system was evaluated in the failing mouse heart.

  16. Dec proteins repressed a MyoD-activated promoter activity of muscle creatine kinase gene through class A E-box in an HDAC1-independent manner.

  17. Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.

Xenopus laevis Creatine Kinase, Muscle (CKM) interaction partners

  1. These data demonstrate that initial phosphocreatine hydrolysis in single skeletal muscle fibers is crucial for maintenance of sarcoplasmic reticulum Ca2+ release and peak tension during a bout of repetitive tetanic contractions.

Pig (Porcine) Creatine Kinase, Muscle (CKM) interaction partners

  1. this study examined the heterogeneity of creatine kinase (CK) forward flux rate of hearts with postinfarction left ventricular (LV) remodeling.

Rabbit Creatine Kinase, Muscle (CKM) interaction partners

  1. water molecules affect protein conformation around residue 268, thereby influencing protein stability at low temperature

  2. role of linker on the isolated C-terminal domain of rabbit muscle creatine kinase

  3. when gly(268) in rabbit muscle-specific creatine kinase was substituted with asn(268), the rabbit muscle-specific CK G286N mutant specific activity at pH 8.0 and 10 degrees C was more than 2-fold higher than that in the wild-type rabbit enzyme

  4. Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates.

  5. In addition to its role in the in vivo functions, the linker also played a crucial role in the stability and folding of CKM.

  6. Changing the substrate specificity of creatine kinase from creatine to glycocyamine.

  7. There are three conformations of CK arranged according to the "energy minimizing principle" by ligated substrates.

  8. These results suggested that the electrostatic interactions were crucial to the action of the linker in CK reactivation.

  9. Study work provides evidence that the presence at the air/water interface of discrete domains with increased charge density, may lead to difference in partition of soluble proteins such as mtCK, interacting with the lipid monolayer.

Creatine Kinase, Muscle (CKM) Antigen Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.

Gene names and symbols associated with CKM

  • creatine kinase, M-type (CKM) antibody
  • creatine kinase, muscle (Ckm) antibody
  • creatine kinase, M-type (Ckm) antibody
  • creatine kinase, M-type L homeolog (ckm.L) antibody
  • creatine kinase, M-type (ckm) antibody
  • creatine kinase, muscle (CKM) antibody
  • creatine kinase, muscle a (ckma) antibody
  • creatine kinase, muscle b (ckmb) antibody
  • cb51 antibody
  • CK-M antibody
  • ckm antibody
  • ckm3 antibody
  • ckmm antibody
  • m-ck antibody
  • mck antibody
  • wu:fa28d05 antibody
  • wu:fb55e09 antibody
  • zgc:64204 antibody
  • zgc:92070 antibody

Protein level used designations for CKM

creatine kinase M chain , creatine kinase M-type , Creatine kinase, muscle form , M-CK , muscle creatine kinase , B-creatine kinase , Creatine kinase M chain , Creatine kinase M-type , creatine kinase, muscle , creatine kinase M-type-like , muscle creatine kinase a

GENE ID SPECIES
1158 Homo sapiens
12715 Mus musculus
24265 Rattus norvegicus
286822 Bos taurus
379765 Xenopus laevis
395005 Xenopus (Silurana) tropicalis
396507 Gallus gallus
397264 Sus scrofa
476435 Canis lupus familiaris
723486 Macaca mulatta
744935 Pan troglodytes
100009056 Oryctolagus cuniculus
100406693 Callithrix jacchus
100455238 Pongo abelii
30095 Danio rerio
101112841 Ovis aries
100733577 Cavia porcellus
794752 Danio rerio
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