-
photo-induced electron transfer reactions in Drosophila melanogaster cryptochrome are indeed influenced by magnetic fields of a few millitesla.
-
Substitutions of four key Trp residues to redox-active tyrosine and redox-inactive phenylalanine tune the light sensitivity of dCRY photoreduction, conformational activation, cellular stability, and targeted degradation of the clock protein timeless
-
we identify the circadian blue-light photoreceptor CRYPTOCHROME as a molecular regulator of Prolonged Morning Wakefulness (PMW), and propose a model in which the Drosophila nervous system integrates information encoding temperature, light, and time to dynamically control when sleep is initiated. Our results provide a platform to investigate how environmental inputs co-ordinately regulate sleep plasticity.
-
The findings of this article for the first time define CRY expression in Drosophila peripheral tissues and reveal that CRY acts together with K(+) channels to maintain passive membrane properties in a non-clock-containing peripheral tissue independent of light.
-
Changes in active site histidine hydrogen bonding trigger cryptochrome activation.
-
CRY is not stabilized by interaction with the kinase Shaggy (SGG), the GSK-3 beta fly orthologue.
-
our studies provided novel evidence that the circadian clock gene, dCry, plays an essential role in heart morphogenesis and function.
-
Using time-resolved and steady-state optical spectroscopy, we studied the mechanism of light-induced radical-pair formation and decay, and the photoreduction of the FAD cofactor.
-
The results of this study concluded that the E oscillators are the targets of light input via CRY and the visual system and are required for normal light entrainment.
-
The Cry leucine-histidine substitution is common in Drosophila, with both alleles at intermediate frequencies across 27 populations surveyed in Europe, irrespective of latitude.
-
Both oxidized and reduced forms of dCRY are capable of photosignaling.
-
Flavin reduction activates Drosophila cryptochrome.
-
Our findings indicate that CRY compensates for limited light sensitivity in vivo by photon integration over extraordinarily long times, and point to select circadian pacemaker neurons as having important roles.
-
dampens temperature-induced PERIOD oscillations in dorsal clock neurons
-
Study reports crystal structures of full-length dCRY, a dCRY loop deletion construct, and the photolyase homology region of mouse CRY1 (mCRY1).
-
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
-
Data indicate that wild-type flies show greatly enhanced magnitude of phase shift, but cryptochrome (CRY)-less flies seem impaired in the ability to integrate duration of the light pulse in a wild-type manner.
-
Study reports that increased nighttime activity of Clk mutants is mediated by high levels of the circadian photoreceptor CRYPTOCHROME (CRY) in large ventral lateral neurons (l-LN(v)s).
-
Drosophila photolyases contain F0 as the second chromophore; within the limitation of the current assay, neither plant nor animal cryptochromes seem to carry a second chromophore.
-
2.3-A resolution crystal structure of Drosophila CRY with an intact C terminus
