anti-Crystallin, gamma C (CRYGC) Antibodies

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYGC Proteins (10) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRYGC 24277 P02529
CRYGC 1420 P07315
CRYGC 12966 Q61597
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Top anti-CRYGC Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CRYGC Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 ug whole cell lysate) A:A431, 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of MCF7 and U251MG cells, using CRYGC antibody. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated WB Crystallin Gamma C antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
$473.93
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 200 μL Log in to see 11 to 12 Days
$364.00
Details
Human Rabbit Cy3 IF (p)   100 μL Log in to see 14 to 21 Days
$428.45
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$428.45
Details

Top referenced anti-CRYGC Antibodies

  1. Human Polyclonal CRYGC Primary Antibody for IF (p), IHC (p) - ABIN1714542 : Aoki, Ogino, Tomita, Hara, Kunisada: Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. in PLoS ONE 2016 (PubMed)

More Antibodies against CRYGC Interaction Partners

Human Crystallin, gamma C (CRYGC) interaction partners

  1. Study identified eight different mutations in CRYGC associated with autosomal dominant congenital nuclear cataracts (ADCC) in a cohort of Chinese family and shows that CRYGC mutations are responsible for 4.1% of ADCC families in the cohort. The results expand the spectrum of CRYGC mutations as well as their associated phenotypes.

  2. We examined a cohort of Chinese patients with congenital cataracts and studied the phenotypes and genotypes. Extralenticular abnormalities, such as microcornea and ocular coloboma, can also be found in patients with congenital cataracts. The phenotype of congenital cataracts associated with macular and optic disc coloboma was reported for the first time in this study.

  3. the G129C mutation in gammaC-crystallin, which is associated with autosomal dominant congenital nuclear cataract, perturbed the unfolding process by promoting the accumulation of two distinct aggregation-prone intermediates under mild denaturing conditions.

  4. Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1.

  5. We confirm that congenital cataract is associated with a CRYGC gene mutation.

  6. identified a CRYAA mutation in family A and a CRYGC mutation in family B with congenital cataract

  7. A nonsense mutation c.471G>A in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree.

  8. Molecular modeling and spectroscopic studies indicated that the mutation impaired the tertiary structure of gamma C crystallin by modifying the H-bonding network in the C-terminal domain.

  9. Transgenic expression of mutant CRYGC5bpd gamma-crystallin at near-physiological levels causes lens opacities and fiber cell defects, confirming the pathogenicity of this mutation.

  10. Two novel nonsynonymous variations and four reported variations in CRYAB, CRYGC, CRYGD, and GJA8, were observed.

  11. The T5P mutation obviously changes conformation and decreases conformational stability.

  12. calculation of the standard free-energy by equilibrium unfolding transition in guanidine hydrochloride

  13. In gammaD-crystallin, methylation is exclusively at Cys 110, whereas in gammaC- and gammaB-crystallins, the principal methylation site is Cys 22 with minor methylation at Cys 79

  14. the loss of interactions of T5P mutant of the gammaC-crystallin with other crystallins may play a larger role than the protection afforded by chaperone-like activity in Coppock-like cataract.

  15. This is the first case of phenotypic heterogeneity in the primary congenital cataract specifically associated with the R168W mutation in the CRYGC gene.

  16. Identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea.

  17. Report a new nonsense mutation (Y56X) in CRYGD and a prev'ly reported missense mutation (R12C) in CRYAA associated with nuclear autosomal dominant congenital cataract in Brazilian families. A new polymorphism (S119S) in CRYGC was observed in one family.

Mouse (Murine) Crystallin, gamma C (CRYGC) interaction partners

  1. a 1-bp deletion in gammaC-crystallin leads to cataract.

  2. presence of measurable interactions between MIP26 and all crystallins, with the extent of interactions decreasing from alphaA- and alphaB-crystallin to betaB2- and gammaC-crystallin.

Cow (Bovine) Crystallin, gamma C (CRYGC) interaction partners

  1. The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens.

CRYGC Antigen Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Gene names and symbols associated with CRYGC

  • crystallin, gamma C (Crygc) antibody
  • crystallin gamma C (CRYGC) antibody
  • crystallin gamma C L homeolog (crygc.L) antibody
  • crystallin, gamma C (CRYGC) antibody
  • crystallin gamma C (Crygc) antibody
  • gamma-crystallin C (LOC100069179) antibody
  • ccl antibody
  • Cryg antibody
  • Cryg-5 antibody
  • cryg3 antibody
  • CRYGC antibody
  • CTRCT2 antibody
  • Len antibody
  • MGC84008 antibody

Protein level used designations for CRYGC

crystallin, gamma polypeptide 3 , gamma-C-crystallin , gamma-crystallin 2-1 , gamma-crystallin C , crystallin, gamma-3 , gamma-crystallin 3 , gammaC-crystallin , gamma-crystallin IIIA , crystallin, gamma C

GENE ID SPECIES
24277 Rattus norvegicus
1420 Homo sapiens
12966 Mus musculus
281722 Bos taurus
444574 Xenopus laevis
709553 Macaca mulatta
737363 Pan troglodytes
100126770 Canis lupus familiaris
100337641 Cavia porcellus
100354942 Oryctolagus cuniculus
100069179 Equus caballus
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