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The protein encoded by CCNK is a member of the transcription cyclin family. Additionally we are shipping Cyclin K Antibodies (65) and Cyclin K Proteins (5) and many more products for this protein.
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SETD1A and cyclin K complexes may represent a therapeutic opportunity for acute myeloid leukemia and, potentially, for other cancers.
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
Structures of CDK12/CycK complexes solved in the presence of AMP-PNP.
Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive.
Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner.
Cyclin K interacts with CDK12 and CDK13 but not CDK9 in cells, and is required to maintain self-renewal in ES cells.
Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
These results reveal an unexpectedly direct role for CDK9-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress.
Cyclin K-expressing multiple myeloma LP-1 cells have lost their migration properties and display enhanced clonogenic capacities
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.
cyclin K may play a role in regulating the cell cycle or apoptosis
The cyclin K fold comprises two typical cyclin boxes with two short helices preceding the N-terminal box. A prominent feature of cyclin K is an additional helix (H4a) in the first cyclin box that obstructs the binding pocket for the p27.
that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.
Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
, cyclin K
, cyclin k