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The protein encoded by CCNK is a member of the transcription cyclin family.
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Structures of CDK12 (show CRKRS ELISA Kits)/CycK complexes solved in the presence of AMP (show APRT ELISA Kits)-PNP (show NP ELISA Kits).
Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12 (show CRKRS ELISA Kits))/cyclin K (CycK) complex, rendering the kinase inactive.
Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner.
Cyclin K interacts with CDK12 and CDK13 but not CDK9 in cells, and is required to maintain self-renewal in ES cells.
Cyclin (show PCNA ELISA Kits) K1 is the primary cyclin (show PCNA ELISA Kits) partner for CDK12/CrkRS (show CRKRS ELISA Kits) and it is required for activation of CDK12/CrkRS (show CRKRS ELISA Kits) to phosphorylate the C-terminal domain of RNA Pol II.
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9 (show CDK9 ELISA Kits))-cyclin T1 (show CCNT1 ELISA Kits) interaction in Nef-dependent manner.
These results reveal an unexpectedly direct role for CDK9 (show CDK9 ELISA Kits)-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress.
Cyclin K-expressing multiple myeloma LP-1 (show RPLP1 ELISA Kits) cells have lost their migration properties and display enhanced clonogenic capacities
P-TEFb (show CCNT1 ELISA Kits) containing cyclin K and Cdk9 (show CDK9 ELISA Kits) can activate transcription via RNA.
cyclin K may play a role in regulating the cell cycle or apoptosis
that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.
Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
, cyclin K
, cyclin k