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CCNT1 encodes a member of the highly conserved cyclin C subfamily. Additionally we are shipping Cyclin T1 Antibodies (63) and Cyclin T1 Proteins (3) and many more products for this protein.
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We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb (show CDK9 ELISA Kits), SEC and Mediator levels in Drosophila embryos.
following P-TEFb (show CDK9 ELISA Kits) inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated
ASF/SF2 (show SRSF1 ELISA Kits) is identified as a splicing regulator (show PTBP2 ELISA Kits) of cyclin T1, which contributes to the control of the subsequent transcription events.
The TAR (show RBM8A ELISA Kits) central loop contacts the CycT1 Tat (show TAT ELISA Kits)-TAR (show RBM8A ELISA Kits) recognition motif (TRM) and the second Tat (show TAT ELISA Kits) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 (show AFF4 ELISA Kits) helix 2 is stabilized in the TAR (show RBM8A ELISA Kits) complex despite not touching the RNA, explaining how it enhances TAR (show RBM8A ELISA Kits) binding to the SEC 50-fold.
Quantitative measurement of the molecular interactions among Tat (show TAT ELISA Kits), CycT1 and CDK9 (show CDK9 ELISA Kits) has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb (show TEF ELISA Kits) complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.
the introduction of HIV-1 Tat (show TAT ELISA Kits) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9 (show CDK9 ELISA Kits)/cyclin T1 complex
AFF4 (show AFF4 ELISA Kits) is positioned to make unexpected direct contacts with HIV Tat (show TAT ELISA Kits), and Tat (show TAT ELISA Kits) enhances P-TEFb/CCNT1 affinity for AFF4 (show AFF4 ELISA Kits).
Plk1 (show PLK1 ELISA Kits) negatively regulates the RNA polymerase II-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 (show CDK9 ELISA Kits) complex.
The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.
the release of P-TEFb from the 7SK snRNP (show LSM2 ELISA Kits) led to increased synthesis of HEXIM1 (show HEXIM1 ELISA Kits) but not HEXIM2 (show HEXIM2 ELISA Kits)
All of the hCD4/R5/cT1 (show CTF1 ELISA Kits) mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone
positive transcription elongation factor b (P-TEFb (show CDK9 ELISA Kits), made of CDK9 (show CDK9 ELISA Kits) and CycT1) is released from its inhibitory complex by histone deacetylase (show HDAC1 ELISA Kits) inhibitors, which also activate HIV transcription
Data show that the minimal 90-amino acid AF9 (show MLLT3 ELISA Kits) fragment in MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1 (show DOT1L ELISA Kits).
Data show that the CDK9 (show CDK9 ELISA Kits) and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 (show CDK9 ELISA Kits) is essential for embryonic genome activation in the mouse.
Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 (show E2F1 ELISA Kits) pathway.
CDK9 (show CDK9 ELISA Kits) has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
P-TEFb is a key mediator of Myc (show MYC ELISA Kits) activated transcription by stimulating elongation
Tat (show TAT ELISA Kits) and trans-activation-responsive (TAR (show RBM8A ELISA Kits)) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1 (show SP1 ELISA Kits).
cyclin T1 binds with granulin (show GRN ELISA Kits) to inhibit transcription
location of the cyclin T1 gene regulatory elements is male germ cell-specific
These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.
knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 (show CD4 ELISA Kits) expression
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
, cyclin T
, cyclin T1
, cyclin T2
, dCyclin T
, CDK9-associated C-type protein
, cyclin C-related protein
, human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
, cyclin T1 protein