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Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 Proteins (CHORDC1)

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Additionally we are shipping Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 Antibodies (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHORDC1 26973 Q9UHD1
CHORDC1 315447 D4A4T9
CHORDC1 66917 Q9D1P4
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Top Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,889.33
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,893.00
Details
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$2,893.00
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,893.00
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,902.17
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,924.17
Details

CHORDC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 (CHORDC1) Interaction Partners

Human Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 (CHORDC1) interaction partners

  1. NF-kappaB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana.

  2. suppression of miR (show MLXIP Proteins)-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication

  3. morgana causes PTEN destabilization, by inhibiting ROCK activity

  4. Chp-1 (show CHP Proteins) and melusin (show ITGB1BP2 Proteins) can interact with cochaperones PP5 (show PPP5C Proteins) and Sgt1 (show SUGT1 Proteins) and with each other in an ATP-dependent manner

  5. A novel ADP-dependent HSP90 (show HSP90 Proteins) interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1, is characterized.

  6. This paper described the cloning of a barley CHORD containing protein, but it also described the CHORD containing proteins in other species including human and characterized the CHORD domains.

Mouse (Murine) Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 (CHORDC1) interaction partners

  1. Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by IkappaBalpha (show NFKBIA Proteins) downregulation.

  2. Loss of Morgana expression is associated with drug resistance and chronic myeloid leukemia (show BCL11A Proteins).

  3. morgana causes PTEN destabilization, by inhibiting ROCK activity

  4. Chp-1 and melusin (show ITGB1BP2 Proteins) can interact with cochaperones PP5 (show PPP5C Proteins) and Sgt1 (show SUGT1 Proteins) and with each other in an ATP-dependent manner

  5. Overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells.

  6. Morgana/chp-1 downregulation promotes the interaction between ROCK II (show ROCK2 Proteins) and nucleophosmin (show NPM1 Proteins), leading to an increased ROCK II (show ROCK2 Proteins) kinase activity, which results in centrosome amplification.

  7. Full length sequence, gene structure and expression of Chp-1.

  8. The first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90 (show HSP90 Proteins)-interacting protein.

  9. results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain.

Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 (CHORDC1) Protein Profile

Protein Summary

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity).

Gene names and symbols associated with CHORDC1

  • cysteine and histidine rich domain containing 1 (CHORDC1)
  • cysteine and histidine rich domain containing 1 (Chordc1)
  • cysteine and histidine-rich domain-containing protein (LOC412067)
  • cysteine and histidine rich domain containing 1 S homeolog (chordc1.S)
  • cysteine and histidine rich domain containing 1 (chordc1)
  • cysteine and histidine-rich domain (CHORD)-containing 1 (Chordc1)
  • cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 (Chordc1)
  • cysteine and histidine-rich domain (CHORD) containing 1b (chordc1b)
  • 1110001O09Rik protein
  • AA409036 protein
  • Chp-1 protein
  • CHP1 protein
  • MGC89160 protein
  • morgana protein
  • NV16801 protein
  • zgc:63894 protein

Protein level used designations for CHORDC1

CHORD-containing protein 1 , CHP-1 , chord domain-containing protein 1 , cysteine and histidine-rich domain (CHORD)-containing 1 , cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 , cysteine and histidine-rich domain-containing protein 1 , protein morgana , CHORD domain-containing protein 1 , morgana , cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 , CHORD containing protein-1

GENE ID SPECIES
26973 Homo sapiens
315447 Rattus norvegicus
412067 Apis mellifera
414542 Xenopus laevis
419009 Gallus gallus
448329 Xenopus (Silurana) tropicalis
466743 Pan troglodytes
476773 Canis lupus familiaris
505144 Bos taurus
694312 Macaca mulatta
100120564 Nasonia vitripennis
100134961 Sus scrofa
100172001 Pongo abelii
66917 Mus musculus
393310 Danio rerio
100726003 Cavia porcellus
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