Cytidine Deaminase Proteins (CDA)

CDA encodes an enzyme involved in pyrimidine salvaging. Additionally we are shipping CDA Antibodies (107) and CDA Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDA 978 P32320
CDA 72269 P56389
Rat CDA CDA 362638  
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Top CDA Proteins at

Showing 10 out of 47 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Human His tag 100 μg 2 to 3 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Yeast REACT_Mycoplasma pneumoniae His tag   1 mg 60 to 71 Days
Yeast REACT_Yersinia pseudotuberculosis His tag   1 mg 60 to 71 Days
Yeast Serratia proteamaculans His tag   1 mg 60 to 71 Days
Yeast Salmonella arizonae His tag   1 mg 60 to 71 Days
Yeast REACT_Proteus mirabilis His tag   1 mg 60 to 71 Days
Yeast Salmonella newport His tag   1 mg 60 to 71 Days

CDA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Cytidine Deaminase (CDA) Interaction Partners

Human Cytidine Deaminase (CDA) interaction partners

  1. data indicate that dominant negative effect of JP41 mutation on class-switch recombination (CSR) is likely due to the depletion of the CSR-specific RNA-binding proteins from WT activation-induced cytidine deaminase

  2. SNPs in CDA and CES2 were associated with benefit from the addition of capecitabine to chemotherapy in metastatic breast cancer patients

  3. The observed incomplete sister chromatid disjunction may be due to the accumulation of unreplicated DNA during mitosis in CDA-deficient cells, as reflected in the changes in centromeric DNA structure associated with the decrease in basal PARP-1 activity.

  4. Intracerebral microdialysis revealed that clonal NSC line to stably express cytosine deaminase (CD-NSCs) produced 5-FU locally in the brain in a 5-FC dose-dependent manner. Collectively, our results from this first-in-human study demonstrate initial safety and proof of concept regarding the ability of NSCs to target brain tumors and locally produce chemotherapy.

  5. results indicate that rs2072671 in CDA may be an important prognostic marker in NK-AML patients.

  6. tumor cell lines that are susceptible to epigenetic nucleosides overexpress cytidine deaminase (CDA); CDA converts 5hmdC and 5fdC into variants of uridine that are incorporated into DNA, resulting in accumulation of DNA damage, and ultimately, cell death

  7. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA) was significantly lower in ex vivo Ara-C sensitive samples.

  8. stimulation of PARP-1 activity in CDA-deficient cells restores replication and, thus, chromosome segregation. Moreover, increasing intracellular dCTP levels generates under-replication-induced sister-chromatid bridges as efficiently as PARP-1 knockdown

  9. n the multivariate Cox regression analysis, we found that age at diagnosis, wild-type genotype of the CDA A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death

  10. Single nucleotide polymorphisms in cytidine deaminase gene were associated with the efficacy of gemcitabine in Biliary Tract Cancer.

  11. Polymorphisms in ABCB1, CDA, ENOSF1,and TYMS could help to predict specific and overall severe adverse reactions to capecitabine.

  12. miR-484-modulated cytidine deaminase has a dual impact in promoting chemoresistance and suppressing cell proliferation in breast cancer

  13. This case report calls for further prospective studies investigating the exact role that CDA status plays in the clinical outcome of patients treated with azacytidine.

  14. The A79C CDA polymorphism did not show a significant impact on the response rate to gemcitabine in NSCLC patients, while the wild type CDA genotype was indeed correlated to a lower rate of incidence of severe anemia in patients taking gemcitabine.

  15. These results suggest that CDA 79A>C polymorphisms is a potential biomarker for toxicity of gemcitabine-based chemotherapy and a CDA testing before gemcitabine administration is preferred.

  16. These results provide suggestive evidence of a favorable effect for the XPD 312Asp/Asp and XPD 751Lys/Lys genotypes with respect to overall survival rates in platinum-treated NSCLC patients

  17. Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase.

  18. The T70 variant has a lower catalytic efficiency toward the analyzed substrates when compared to the A70 variant, suggesting that patients carrying the 208G>A SNP may have a greater exposure to cytosine based pro drugs

  19. Carriers of the CDA*2B haplotype displayed higher CDA activity.

  20. ultrarapid metabolizer patients are nearly five-times more likely to have progressive disease than patients with normal or low CDA activities.

Mouse (Murine) Cytidine Deaminase (CDA) interaction partners

  1. Data indicate that a combination cytosine deaminase (CDA)/uracil phosphoribosyltransferase protein (UPRT)-expressing adipose tissue-derived mesenchymal stem cells (AT-MSCs) with lysomustine has a superior antitumor effect in the lung carcinoma model compared to monotherapies with transfected AT-MSCs or lysomustine alone.

  2. On the basis of known structures, structural analysis further reveals two subclasses of homotetrameric CDAs that can be identified according to the position of the charge-neutralizing arginine residue.

  3. a drug-resistance gene highly suitable for myeloprotective purposes, which might best be used in combination with selectable drug-resistance genes.

  4. Activation-induced cytidine deaminase plays an important role in the containment of autoimmune diseases by negative regulation of autoreactive B cells.

CDA Protein Profile

Protein Summary

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

Gene names and symbols associated with Cytidine Deaminase Proteins (CDA)

  • cytidine deaminase (CDA)
  • cytidine deaminase (cda)
  • cytidine deaminase (VNG_RS03500)
  • cytidine deaminase (OE_RS03485)
  • cytidine deaminase (CDD1)
  • cytidine aminohydrolase; CDA (cdd)
  • cytidine deaminase b (cdab)
  • Cytidine deaminase (cdd-1)
  • Cytidine deaminase (cdd-2)
  • cytidine deaminase Cdd (cdd)
  • cytidine deaminase (CNC04940)
  • cytidine deaminase (Tb09.160.1680)
  • cytidine deaminase (Cda)
  • 2210401N16Rik protein
  • cda protein
  • CDD protein
  • DDBDRAFT_0188181 protein
  • DDBDRAFT_0230205 protein
  • DDB_0188181 protein
  • DDB_0230205 protein
  • zgc:77948 protein

Protein level used designations for Cytidine Deaminase Proteins (CDA)

cytidine deaminase , CytiDine Deaminase family member (cdd-1) , CytiDine Deaminase family member (cdd-2) , cytidine aminohydrolase , cytosine nucleoside deaminase , small cytidine deaminase

705913 Macaca mulatta
549971 Xenopus (Silurana) tropicalis
487393 Canis lupus familiaris
616377 Bos taurus
1447638 Halobacterium sp. NRC-1
5954454 Halobacterium salinarum R1
5719128 Chlamydomonas reinhardtii
3431029 Haemophilus influenzae 86-028NP
402979 Danio rerio
771849 Gallus gallus
744046 Pan troglodytes
8626880 Dictyostelium discoideum AX4
183546 Caenorhabditis elegans
186044 Caenorhabditis elegans
1170491 Shewanella oneidensis MR-1
3256143 Cryptococcus neoformans var. neoformans JEC21
3660189 Trypanosoma brucei brucei strain 927/4 GUTat10.1
978 Homo sapiens
72269 Mus musculus
362638 Rattus norvegicus
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