Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 Proteins (CYP1A2)

CYP1A2 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP1A2 Antibodies (190) and CYP1A2 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP1A2 1544 P05177
CYP1A2 13077 P00186
CYP1A2 24297 P04799
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Top CYP1A2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$1,520.00
Details
Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
$125.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$608.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,455.83
Details
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

CYP1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,
,

Top referenced CYP1A2 Proteins

  1. Human CYP1A2 Protein expressed in Wheat germ - ABIN1350938 : Kawakami, Ohtsuki, Kamiie, Suzuki, Abe, Terasaki: Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection. in Journal of pharmaceutical sciences 2010 (PubMed)

More Proteins for Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) Interaction Partners

Human Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. our findings suggest that CYP1A2, CYP3A4 (show CYP3A4 Proteins) and CYP3A5 (show CYP3A5 Proteins) play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response

  2. CYP1A2 rs2470890 was significantly associated with the prognosis of patients with breast cancer and could serve as an independent impact factor of prognosis of breast carcinoma

  3. Computational molecular modeling tools have been used by several research groups to decipher the specificity and potency factors of the CYP1A1 (show CYP1A1 Proteins) and CYP1A2 substrates. In this review, we perform a thorough analysis of the computational studies that are ligand-based and protein-ligand complex-based to catalog the various factors that govern the specificity/potency toward these two enzymes

  4. CYP1A2 activity can be monitored using noninvasive random urine samples, and it can be used to assess developmental changes in theophylline clearance by preterm

  5. The increased risk of prostate cancer was observed among individuals with the CYP1A2 CA + AA genotype (OR, 1.43; 95% CI, 1.03-2.00).

  6. Nerolidol induces endoplasmic reticulum stress and apoptosis in Human HepG2 Cells through extensive CYP2C19 (show CYP2C19 Proteins) and CYP1A2 mediated drug oxidation.

  7. Findings show that at allelic and genotypic level polymorphisms in CYP3A4 (show CYP3A4 Proteins) and CYP1A2 are significantly associated with a reduced risk of drug addiction in Chinese individuals.

  8. In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance

  9. Study corroborated results from a previous report that described interactions between ADORA2A (show ADORA2A Proteins) and CYP1A2 polymorphisms and coffee consumption in Parkinson's disease.

  10. CYP1A2 Polymorphisms are associated with lung cancer.

Rabbit Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. CYP1A1 (show CYP1A1 Proteins) and CYP1A2 localization into different lipid microdomains is governed by their N-terminal and internal protein regions

  2. Removal of cholesterol (an important constituent of ordered domains) led to the relocation of CYP1A2, CYP2B4 and CPR (show POR Proteins) to the disordered regions.

  3. Oxidation kinetics of toluene in CYP1A2-CYP2B4 mixtures with and without cytochrome p450 reductase (CPR (show POR Proteins)) are consistent with a model in which CYP1A2 has a higher affinity for CPR (show POR Proteins) binding.

Mouse (Murine) Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. our results suggest a more important contribution of CYP1A2 (show CYP1A1 Proteins) to the in vivo plasma clearance and thus detoxification of 4-Aminobiphenyl

  2. hepatic CYP1A2 (show CYP1A1 Proteins) plays a critical role in the attenuation of hyperoxic lung injury by decreasing lipid peroxidation and oxidative stress in vivo.

  3. Aryl hydrocarbon receptor (show AHR Proteins) mediated induction of hepatic CYP1A1 (show CYP1A1 Proteins)/1A2 is dependent on the presence of ctnnb1 (show CTNNB1 Proteins).

  4. Results indicate Cyp1a2 (show CYP1A1 Proteins) genotype is important in susceptibility to PCB (show PC Proteins)-induced deficits in learning and memory.

  5. Miroestrol and deoxymiroestrol significantly up-regulated CYP2B9 while suppressing CYP1A2 (show CYP1A1 Proteins) at both transcriptional and enzymatic levels.

  6. A report of uroporphyria development in Cyp1a2 (show CYP1A1 Proteins)-/- mice additionally null for both alleles of the hemochromatosis (Hfe (show HFE Proteins)) gene and heterozygous for deletion of the uroporphyrinogen decarboxylase (Urod (show UROD Proteins)) gene (genotype: Cyp1a2 (show CYP1A1 Proteins)-/-;Hfe (show HFE Proteins)-/-;Urod (show UROD Proteins)+/-).

  7. High levels of maternal hepatic CYP1A2 (show CYP1A1 Proteins) protect against deficits in learning and memory in offspring exposed to a mixture of coplanar and noncoplanar PCBs; high-affinity AHR (show AHR Proteins) is the next most important factor in protection of offspring.

  8. In rodents, aristolochic acid demethylation, mediated by CYP1A2 (show CYP1A1 Proteins), is a primary pathway of aristolochic acid detoxication.

  9. The expression of Cyp1a1 (show CYP1A1 Proteins), Cyp1a2 (show CYP1A1 Proteins), and OGG1genes was significantly up-regulated in mice given diets containing 375 ppm dicyclanil or more.

  10. the TRE (show TREH Proteins) element in E1 is essential for constitutive expression of the mouse Cypla2 gene

Pig (Porcine) Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. In the present study, CYP1A2 expression in liver increased in groups exposed to single exposures of 5 mgkg-bw- 1 (p = 0.044) and 20 mgkg-bw- 1 (p = 0.033) relative to controls

  2. This study demonstrated for the first time that the serum testosterone level is one of the physiological factors which regulate constitutive expression of hepatic CYP1A1 (show CYP1A1 Proteins) and CYP1A2 in pigs.

  3. The findings demonstrate a gender-related difference in the constitutive expression of hepatic CYP1A2 in Meishan pigs and further indicate that testosterone down-regulates the constitutive gene expression of the enzyme.

  4. Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2

  5. Effect of beta-napthoflavone on AHR (show AHR Proteins)-related gene, CYP1A2, in the pig is reported.

CYP1A2 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Gene names and symbols associated with CYP1A2

  • cytochrome P450 family 1 subfamily A member 2 (CYP1A2)
  • cytochrome P450 1A2 (CYP1A2)
  • cytochrome P450 LM4 (LOC100328937)
  • cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)
  • cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2)
  • cytochrome P450 1A2 (VDBG_06455)
  • cytochrome P450 1A2-like (LOC101825565)
  • cytochrome P450 1A2 (LOC102130662)
  • CP12 protein
  • CP450 protein
  • CYP-IA2 protein
  • Cyp1a1 protein
  • CYP1A2 protein
  • CYP1A5 protein
  • CYPD45 protein
  • CYPIA2 protein
  • P-450d protein
  • P3-450 protein
  • P450(PA) protein
  • P450-3 protein
  • P450-PM4 protein
  • RATCYPD45 protein

Protein level used designations for CYP1A2

CYPIA2 , P450 form 4 , aryl hydrocarbon hydroxylase , cytochrome P(3)450 , cytochrome P450 1A2 , cytochrome P450 4 , cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 , cytochrome P450-P3 , dioxin-inducible P3-450 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , P450 LM4 , P450 isozyme 4 , cytochrome P450 isozyme 4 , cytochrome P450-PM4 , aromatic compound inducible , cytochrome P450 family 1 subfamily a polypeptide 1 , cytochrome P450, 1a2, aromatic compound inducible , cytochrome P450-P2 , Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d) , P-448 , P450-D , cytochrome P-448 , cytochrome P-450d , cytochrome P450, 1a2 , cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d) , cytochrome P450-D , CYPIA5 , cytochrome P450 1A5 , cytochrome P450 TCDDAA , Cytochrome P450-MC4 , Hepatic cytochrome P-450MC1 , cytochrome P-450 form 4 , cytochrome P-450IA2 , pulmonary cytochrome P-450MC1 , Cholesterol 25-hydroxylase , cholesterol 25-hydroxylase , cytochrome P-450 , cytochrome P450, family 1, subfamily A, polypeptide 2

GENE ID SPECIES
1544 Homo sapiens
554345 Felis catus
100328937 Oryctolagus cuniculus
100172368 Pongo abelii
13077 Mus musculus
24297 Rattus norvegicus
494010 Canis lupus familiaris
9536166 Verticillium alfalfae VaMs.102
100135513 Cavia porcellus
100152910 Sus scrofa
396051 Gallus gallus
101825565 Mesocricetus auratus
100392712 Callithrix jacchus
102130662 Macaca fascicularis
503552 Bos taurus
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