Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 Proteins (CYP2C9)

CYP2C9 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2C9 Antibodies (57) and CYP2C9 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP2C9 1559 P11712
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Top CYP2C9 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

CYP2C9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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More Proteins for Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9) Interaction Partners

Human Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9) interaction partners

  1. We compared the carrier frequency of Cytochrome P450 Enzymes and Transport Proteins markers among the Russian population living in Moscow with Dagestan ethnic groups. Statistically significant differences for the following gene polymorphisms: CYP2C19 (show CYP2C19 Proteins)*17, CYP2C9*3, ABCB1 (show ABCB1 Proteins) (C3435T), SLCO1B1 (show SLCO1B1 Proteins)*5 were found between the Russian population and the three ethnic groups of the Dagestan republic.

  2. Angiotensin II receptor blockers exhibit different degrees of inhibition of the metabolism of arachidonic acid by recombinant CYP2C9, CYP2J2 (show CYP2J2 Proteins) and liver microsomes.

  3. analysis of VKORC1 (show VKORC1 Proteins) AA-CYP2C9*1*1 genotypes reveals dosing algorithms for vitamin K antagonists

  4. In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2 (show CYP1A2 Proteins), 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance

  5. To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk. CYP2C9*2 and *3 allele variants modify benzodiazepine-related fall risk. Those using benzodiazepines and having reduced CYP2C9 enzyme activity based on their genotype are at increased fall risk.

  6. In an Indian population of children with epilepsy on phenytoin monotherapy, CYP2C9*1, *2 & *3 allelic frequencies were 85.4, 4.5 and 10.1 % respectively. CYP2C9*3 allelic group showed significantly higher serum phenytoin levels compared to the wild variants.

  7. The genotype distributions of the CYP2C9*3, CYP2D6 (show CYP2D6 Proteins)*10, and CYP3A5 (show CYP3A5 Proteins)*3 genetic polymorphisms were associated with the warfarin maintenance dose.

  8. CYP2C9*2 and CYP2C9*3 genetic polymorphisms are associated with reduced S-warfarin oral clearance in healthy subjects

  9. Case Report: time course of CYP2C9 deinduction appeared to be delayed compared to CYP3A after discontinuation of rifampicin therapy.

  10. Data suggest that SNPs in CYP2C9 (*3, I359L; *30, A477T) that reduce catalytic activity of CYP2C9 also alter interaction with antihypertensive drug losartan; I359L substitution located far from active site remarkably alters residue side chains near active site and access channel, whereas the T477 substitution illustrates hydrogen-bonding interaction with reoriented side chain of Q214.

CYP2C9 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Gene names and symbols associated with CYP2C9

  • cytochrome P450 family 2 subfamily C member 9 (CYP2C9)
  • CPC9 protein
  • CYP2C protein
  • CYP2C10 protein
  • CYPIIC9 protein
  • P450IIC9 protein

Protein level used designations for CYP2C9

cytochrome P-450 S-mephenytoin 4-hydroxylase , cytochrome P-450MP , cytochrome P450 2C9 , cytochrome P450 PB-1 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase

1559 Homo sapiens
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