Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Proteins (CYP2E1)

CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Antibodies (180) and Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP2E1 1571 P05181
CYP2E1 13106 Q05421
CYP2E1 25086 P05182
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Top Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$3,259.67
Details
Yeast Golden Syrian Hamster His tag   1 mg Log in to see 60 to 71 Days
$3,393.50
Details
Yeast Rhesus Monkey His tag   1 mg Log in to see 60 to 71 Days
$3,393.50
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$749.00
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Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$560.00
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,393.50
Details

CYP2E1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaction Partners

Rabbit Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. The localization of CYP1A2 (show CYP1A2 Proteins), CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98

Guinea Pig Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Cytochrome P450 2E1 takes part in the pathogenesis of experimental metabolic syndrome in guinea pigs.

Human Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. The observations of the present study give rise to useful information on CYP2E1 polymorphisms in Chinese Uygur individuals.

  2. results provide new information regarding CYP2E1 genetic polymorphisms in Chinese Tibetan population. These findings in this study would be value for further study in assessing the susceptibility of different populations to diseases related to CYP2E1 polymorphisms and determining whether it is necessary to design different therapeutics and toxicological protocols to reduce the risk of population, including pharmacogenetic

  3. Clomethiazole is a direct inhibitor of human CYP2E1 when coincubated with the probe substrate chlorzoxazone.

  4. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction.

  5. Polymorphisms in the promoter region of the CYP2E1 gene were associated with DNA damage in alcoholics.

  6. We identified an exposure-associated differentially methylated region (DMR (show WDR20 Proteins)) spanning nine sequential CpG sites in the promoter-regulatory region of the cytochrome P450 2E1 gene (CYP2E1) on chromosome 10 (corrected P=2.98 x 10(-5)). Elevated DNA methylation (show HELLS Proteins) across this region was also associated with deprivation-related clinical markers of impaired social cognition.

  7. A significant increase in the risk of non-small cell lung cancer was observed for the following combinations: TP53 (show TP53 Proteins) codon72 variant with GSTM1 (show GSTM1 Proteins) null (OR 2.22, 95 % CI 1.23-4.04; p=0.009), GSTT1 (show GSTT1 Proteins) null (OR 2.98, 95 % CI 1.49-5.94; p=0.002), and GSTP1 (show GSTP1 Proteins) (Ala114Val) variant genotypes (OR 3.38, 95 % CI 1.54-7.41; p=0.002).

  8. Studied the possible relationship between cytochrome P450, family 2, subfamily E and polypeptide 1 (CYP2E1) polymorphisms with Kawasaki disease (KD). Found the KD patients with a CYP2E1 CC genotype of rs915906 demonstrated a greater proportion of coronary artery lesions (CALs (show CA8 Proteins)) formation.

  9. The results suggest that changes in coumarin pharmacokinetics and CYP2E1 subcellular distribution contribute to resistance to coumarin-induced hepatic necrosis, while cytotoxicity of metabolic conjugates shown in vitro may contribute to bile duct damage upon repeated coumarin administration.

  10. Data suggest a homeostatic, gene dosage-insensitive regulation of CYP2E1 expression by unknown gene dosage compensation mechanisms.

Mouse (Murine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction/

  2. we show that TRPV4 (show TRPV4 Proteins) is activated both by damage associated molecular pattern HMGB1 (show HMGB1 Proteins) and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3 (show NOS3 Proteins)) to release nitric oxide (NO). The diffusible NO acts in a paracrine fashion in neighboring hepatocytes to deactivate the redox toxicity induced by CYP2E1

  3. Data, including data from studies in knockout mice, suggest that the oxidative metabolism of 1,2-dichloropropane, a carcinogenic solvent/insecticide, is exclusively catalyzed by Cyp2e1; this biotransformation step is indispensable for manifestation of hepatotoxic effect of the solvent.

  4. Taken together, these results suggested that 1,2-dichloroethane (1,2-DCE (show DHCR24 Proteins)) could enhance CYP2E1 protein expression and enzymatic activity, which could cause oxidative damage in liver, serving as an important mechanism underlying 1,2-DCE (show DHCR24 Proteins)-induced liver damage

  5. CYP2E1 is important in causing aging-dependent hepatic steatosis, apoptosis and fibrosis possibly through increasing nitroxidative stress.

  6. Our results support a significant role for CYP2E1 as a novel 4-Aminobiphenyl N-oxidizing enzyme in adult mice

  7. Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53 (show TP53 Proteins), p21, CCND1 (show CCND1 Proteins), PCNA (show PCNA Proteins), and BCL-2 (show BCL2 Proteins) to promote liver regeneration.

  8. Studied hepatic stellate cell cytoglobin (show CYGB Proteins) involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.

  9. Data suggest that expression of Cyp2e1 in adipose tissue can be regulated by dietary factors; here, expression of Cyp2e1 in white adipose tissue is down-regulated in obesity caused by high-fat diet.

  10. The Cyp2e1-null mice displayed a susceptibility to lung toxicity of styrene similar to that of the wild-type animals; however, Cyp2f2-null mice were resistant to styrene-induced pulmonary toxicity.

Pig (Porcine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14.

  2. The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported.

Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene names and symbols associated with CYP2E1

  • cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1)
  • cytochrome P450 2E1 (CYP2E1)
  • cytochrome P450 2E1 (PTRG_07411)
  • cytochrome P450 2E1 (LOC100342572)
  • cytochrome P450 2E1 (LOC100727914)
  • cytochrome P450 2E1-like (LOC101843716)
  • cytochrome P450 family 2 subfamily E member 1 (CYP2E1)
  • cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1)
  • CPE1 protein
  • Cyp2e protein
  • CYP2E1 protein
  • CYPIIE1 protein
  • P450-J protein
  • P450C2E protein

Protein level used designations for CYP2E1

cytochrome P450 2E1 , 4-nitrophenol 2-hydroxylase , Cytochrome P450 2E1 , Cytochrome P450 LM3A , Cytochrome P450 isozyme 3A , Cytochrome P450-ALC , Cytochrome P450-J , cytochrome P-450j , CYPIIE1 , cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 , cytochrome P450-J , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , cytochrome P450, 2e1, ethanol inducible , cytochrome P450-ALC , P450-J , P450RLM6 , cytochrome P450 subfamily 2e1 (ethanol-inducible) , cytochrome P450, subfamily 2E, polypeptide 1 , cytochrome P450RLM6 , cytochrome P-450-J , cytochrome P450 CYP2E1

GENE ID SPECIES
100066422 Equus caballus
554344 Felis catus
6345684 Pyrenophora tritici-repentis Pt-1C-BFP
100342572 Oryctolagus cuniculus
100727914 Cavia porcellus
101843716 Mesocricetus auratus
1571 Homo sapiens
415128 Canis lupus familiaris
13106 Mus musculus
25086 Rattus norvegicus
403216 Sus scrofa
282213 Bos taurus
100568285 Ovis aries
678688 Macaca mulatta
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