Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 Proteins (CYP51A1)

Mouse (Murine) Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 (CYP51A1) interaction partners

1. CYP51 is a mediator of T3 and FSH (show BRD2 Proteins)-induced follicular development.

2. Our Cyp51 LKO model shows that steatosis appears with dietary fats in the absence of dietary cholesterol and its synthesis, while a block in the cholesterol pathway leads to NASH (show SAMSN1 Proteins)-like features

3. germ cell-specific ablation of Cyp51, leading to lack of MAS (show MAS1 Proteins), did not affect testicular morphology, daily sperm production, or reproductive performance in males.

4. Cyp51 knock-out mice provide evidence that Cyp51 is essential for embryogenesis and present a potential animal model for studying ABS syndrome in humans.

5. Findings suggest that FSH (show BRD2 Proteins), partially at least, employs CYP51, and therefore the MAS (show MAS1 Proteins) pathway, to initiate oocyte meiosis.

6. localization of CYP51 in testis and ovary shows Leydig cells and acrosomes of spermatids express the highest levels

7. Demethylation of lanosterol to FF-MAS (show MAS1 Proteins) by the acrosomal lanosterol 14 alpha-demethylase enzyme complex demonstrates for the first time the ability of ejaculate sperm to synthesize meiosis-activating sterols.

8. A gene participating in cholesterol bisynthesis (CYP51) is regulated in an immediate early (show JUN Proteins) fashion, which influences sterol profile of the cell.

9. there was a cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through , low-density lipoprotein receptor (show LDLR Proteins) in vivo

10. These data indicate that Crem-dependent regulation of Cyp51 in the liver results in circadian expression of this gene.

Human Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 (CYP51A1) interaction partners

1. the regulation of expression of human CYP51A1, the lanosterol 14alpha-demethylase (show MBD2 Proteins), is reported.

2. Molecular insights regarding substrate profile, faster catalysis, and weaker susceptibility of human CYP51 to inhibition.

3. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1 (show CYP17A1 Proteins), CYP19A1 (show CYP19A1 Proteins) and CYP51A1.

4. Suggest that GDF9 (show GDF9 Proteins), possibly with FSH (show BRD2 Proteins), may play significant roles in the regulation of cholesterol biosynthesis and the expression of CYP51A1 in granulosa cells which might be a predictor for unfertilization.

5. Data show that forkhead transcription factor 4 (FoxO4) interacts with sterol regulatory element binding protein (SREBP)2 and hypoxia inducible factor (HIF)2alpha to modulate lanosterol 14alpha demethylase (CYP51) promoter activity.

6. Our results indicate a new link between a cholesterol synthesis gene CYP51A1 and pregnancy pathologies.

7. The studied azoles selectively interacted with human cytochrome P450 51A1, which showed the highest affinity towards ketoconazole.

8. Low nucleotide variability of CYP51A1 is seen in cholesterol and bile acid synthesis and xenobiotic metabolism pathways.

9. The new CYP51A1 inhibitor 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LEK-935) on the proteome of primary human hepatocytes were analyzed.

10. A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase (show MBD2 Proteins) gene.