anti-Cytohesin 2 (CYTH2) Antibodies

The protein encoded by CYTH2 is a member of the PSCD family. Additionally we are shipping Cytohesin 2 Proteins (10) and Cytohesin 2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYTH2 9266 Q99418
CYTH2 19158 P63034
CYTH2 116692 P63035
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Top anti-Cytohesin 2 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN238611 (0.5µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PSCD2 Antibody (N-term) in mouse kidney tissue lysates (35ug/lane). This demonstrates the PSCD2 antibody detected the PSCD2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated IF, ELISA, WB 100 μg 11 to 14 Days
$551.83
Details
Cow Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to CYTH2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to CYTH2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Details
Dog Goat Un-conjugated WB   0.1 mg 4 to 8 Days
$462.00
Details
Mouse Rabbit Un-conjugated WB Western blot analysis in mouse kidney tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Cow Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IP, WB Immunoprecipitation of CYTH2 transfected lysate using anti-CYTH2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with CYTH2 MaxPab mouse polyclonal antibody (B01) . Western Blot analysis of CYTH2 expression in transfected 293T cell line by CYTH2 MaxPab polyclonal antibody.Lane 1: CYTH2 transfected lysate(46.5 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of CYTH2 expression in transfected 293T cell line by CYTH2 MaxPab polyclonal antibody.Lane 1: CYTH2 transfected lysate(44 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details

Top referenced anti-Cytohesin 2 Antibodies

  1. Human Monoclonal Cytohesin 2 Primary Antibody for IF, IHC (p) - ABIN564002 : Mannell, Pircher, Chaudhry, Alig, Koch, Mettler, Pohl, Krötz: ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression. in Cardiovascular research 2011 (PubMed)

  2. Dog (Canine) Polyclonal Cytohesin 2 Primary Antibody for ELISA, WB - ABIN548044 : Kolanus: Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction. in Immunological reviews 2007 (PubMed)

More Antibodies against Cytohesin 2 Interaction Partners

Human Cytohesin 2 (CYTH2) interaction partners

  1. INAVA-CUPID exhibits dual functions, coordinated directly by ARNO, that bridge epithelial barrier function with extracellular signals and inflammation.

  2. ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.

  3. Authors' experiments argue against ARNO being a robust modifier of EGFR catalytic activity.

  4. Data establish a role for cytohesin-2/ARNO as a regulator of R-Ras and integrin recycling and suggest that ARF-regulated trafficking of R-Ras is required for R-Ras-dependent effects on spreading and adhesion formation.

  5. The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 guanine nucleotide exchange factor (GEF) ARF nucleotide binding site opener (ARNO) to bacterial entry sites.

  6. inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR and IGF-I in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro.

  7. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 in a GTP-bound state

  8. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 activation and neurite extension.

  9. Phosphorylation of Ser392 of ARNO stabilized the C-terminal alpha-helix via formation of salt bridges between phospho-Ser392 and Arg390, Lys395, and Lys396.

  10. There is an association between cytohesin-2 expression and overall survival and disease-free survival in patients with hepatocellular carcinoma.

  11. Arf6/ ARNO signaling mediates phospholipase-D, ERK1/2 and cofilin activation in pancreatic beta-cells.

  12. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A

  13. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

  14. The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin.

  15. ARNO in turn triggered WAVE regulatory complex recruitment and activation, which was dramatically enhanced when ARNO cooperated with Salmonella SopE.

  16. role for endothelial ARNO in VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, resulting in the activation of the Akt pathway, vessel permeability, and ultimately endothelial proliferation

  17. Data that aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton.

  18. Arno behaves as a bistable switch, having an absolute requirement for activation by an Arf protein but, once triggered, becoming highly active through the positive feedback effect of Arf1-GTP.

  19. cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor

  20. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.

Mouse (Murine) Cytohesin 2 (CYTH2) interaction partners

  1. results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac

  2. The RLIP76/R-Ras/ARNO complex localizes to recycling endosomes.

  3. signaling through cytohesin-2 is required for myelination by Schwann cells, and cytohesin-2 is added to the list of molecules known to underlie PNS myelination

  4. results together suggest that cytohesin 2 activates ARF6 in a PI3K dependent manner and then the active ARF6 causes phosphorylation of ERK1/2 during preadipocyte migration.

  5. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 in a GTP-bound state

  6. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 activation and neurite extension.

  7. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

  8. role for endothelial ARNO in VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, resulting in the activation of the Akt pathway, vessel permeability, and ultimately endothelial proliferation

  9. cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor

  10. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.

  11. Arl4D is a previously unknown regulator of neurite formation through cytohesin-2 and Arf6, providing another example that the functional interaction of two different small GTPases controls an important cellular function.

Cytohesin 2 (CYTH2) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Cytohesin 2 (CYTH2) Antibodies

  • cytohesin 2 (CYTH2) antibody
  • cytohesin-2 (PTRG_08834) antibody
  • cytohesin 2 (Cyth2) antibody
  • cytohesin 2 L homeolog (cyth2.L) antibody
  • cytohesin 2 (cyth2) antibody
  • si:dkey-283b15.4 (si:dkey-283b15.4) antibody
  • Arno antibody
  • CLM2 antibody
  • CTS18 antibody
  • CTS18.1 antibody
  • cyth2 antibody
  • MGC84366 antibody
  • pscd2 antibody
  • PSCD2L antibody
  • Sec7 antibody
  • Sec7B antibody
  • SEC7L antibody
  • Sec7p-L antibody
  • Sec7p-like antibody

Protein level used designations for anti-Cytohesin 2 (CYTH2) Antibodies

ARF exchange factor , ARF nucleotide-binding site opener , PH, SEC7 and coiled-coil domain-containing protein 2 , cytohesin-2 , pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2) , SEC7 homolog B , mSec7-2 , pleckstrin homology, Sec7 and coiled-coil domains 2 , ARF nucleotide binding site opener , CLM2 , cytohesin 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 , cytohesin-2-like , LOW QUALITY PROTEIN: cytohesin-2

GENE ID SPECIES
9266 Homo sapiens
6347120 Pyrenophora tritici-repentis Pt-1C-BFP
19158 Mus musculus
116692 Rattus norvegicus
444689 Xenopus laevis
448569 Xenopus (Silurana) tropicalis
476423 Canis lupus familiaris
718682 Macaca mulatta
746757 Pan troglodytes
768035 Bos taurus
100216436 Ovis aries
100240721 Sus scrofa
100387102 Callithrix jacchus
100440057 Pongo abelii
100731442 Cavia porcellus
569358 Danio rerio
100350140 Oryctolagus cuniculus
100053821 Equus caballus
Selected quality suppliers for anti-Cytohesin 2 (CYTH2) Antibodies
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