Cytokeratin 1 Proteins (KRT1)

The protein encoded by KRT1 is a member of the keratin gene family. Additionally we are shipping KRT1 Antibodies (206) and KRT1 Kits (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT1 3848 P04264
KRT1 16678 P04104
KRT1 300250 Q6IMF3
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Top KRT1 Proteins at

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse Keratin 1 Protein. 100 μg 11 to 18 Days
Yeast Rat His tag   1 mg 60 to 71 Days

KRT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Cytokeratin 1 (KRT1) Interaction Partners

Human Cytokeratin 1 (KRT1) interaction partners

  1. A colon score derived from serum CEA, CA19-9, CK1 and MUC1 is a potential valuable non-invasive index that could be used for detection and screening early stage colon cancer patients

  2. PAWS1 interacts and co-localises with the alpha isoform of casein kinase 1 (CK1), and that PAWS1 mutations incapable of binding CK1 fail both to activate Wnt signalling and to elicit axis duplication in Xenopus embryos.

  3. Results showed identical expression pattern for KRT1 and KRT10, their expression was higher in pediatric cases than in adults, especially in pediatric recurrent samples.

  4. The authors report a large Italian family affected Palmoplantar Keratoderma and Charcot Marie Tooth disease. Two different mutated genes, KRT1 and MPZ were responsible for the two main clinical signs. Exome analysis detected two missense mutations, one in KRT1 and one in MPZ.

  5. Results show that missense mutations exert dominant negative effects on the keratins K1/K10 protein structure by altering inter-chain interactions.

  6. KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc

  7. Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis.

  8. KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.

  9. Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis.

  10. demonstrated the presence of a genetic cutaneous mosaicism. Both patients carry the KRT1 pI479T substitution, but in the palmoplantar areas of one of them, only the mutated allele is expressed (hemizygous). This leads to highlight a new type of cutaneous mosaic, the palmoplantar mosaicism

  11. In our study, the missense mutation in the proband and his mother with epidermolytic ichthyosis was a single amino acid difference in codon 478, which causes more serious skin manifestations

  12. Complete structure of an epithelial keratin 1/keratin 10 dimer has been presented.

  13. These findings indicate that exogenous FABP4 interacts with plasma membrane proteins, specifically CK1.

  14. analysis of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma

  15. In ichthyosis with confetti, a causal de novo KRT1 mutation had a C-terminal frameshift, replacing 22 C-terminal AAs with an alternate 30-AA peptide. It distorted the IF network and mislocalized to the nucleus. Reversion occurred by mitotic recombination.

  16. In HeLa cells transiently expressing C2GnT-M-GFP, knockdown of KRT1 does not affect Golgi morphology but leaves C2GnT-M outside of the Golgi, resulting in the formation of sialyl-T antigen.

  17. Decreased levels of cytokeratin-1 is associated with breast cancer.

  18. Hsp74, a potential bladder cancer marker, has direct interaction with keratin 1.

  19. identified among endothelial antigens to which antibodies are produced during heart transplant rejection

  20. Case Report/Letter: specific mutation in 2B domain of KRT1 gives rise to mild phenotype of epidermolytic hyperkeratosis mimicking ichthyosis bullosa of Siemens.

Mouse (Murine) Cytokeratin 1 (KRT1) interaction partners

  1. SCF improves diabetic wound healing in part by increasing the recruitment of a unique stem cell population present in the skin.

  2. Absence of Krt1 caused a prenatal increase in interleukin-18 (IL-18) and the S100A8 and S100A9 proteins, accompanied by a barrier defect and perinatal lethality.

  3. The Krt1(-/-);Krt10(-/-) mice showed premature loss of nuclei during epidermal differentiation and lower levels of emerin, lamin A/C and Sun1, revealing a previously unknown function for IFs in maintaining nuclear integrity in the upper epidermis.

KRT1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene names and symbols associated with Cytokeratin 1 Proteins (KRT1)

  • keratin 1 (KRT1)
  • keratin 1 (Krt1)
  • CK-1 protein
  • CK1 protein
  • EHK protein
  • EHK1 protein
  • EPPK protein
  • K1 protein
  • Kb1 protein
  • KER1 protein
  • Keratin-1 protein
  • Krt-2.1 protein
  • KRT1 protein
  • KRT1A protein
  • Krt2-1 protein
  • Krt86 protein
  • NEPPK protein

Protein level used designations for Cytokeratin 1 Proteins (KRT1)

67 kDa cytokeratin , CK-1 , cytokeratin 1 , cytokeratin-1 , epidermolytic hyperkeratosis 1 , hair alpha protein , keratin, type II cytoskeletal 1 , type-II keratin Kb1 , K1 , keratin 86 , keratin complex 2, basic, gene 1 , keratin-1 , keratin 1 , cytokeratin VI (human cytokeratin 10) , cytokeratin Ia (human cytokeratin 1, epidermolytic hyperkeratosis) , type II keratin Kb1 , epithelial keratin 1 , epithelial keratin-1 , keratin 1 (epidermolytic hyperkeratosis) , Cytokeratin-1 , Keratin, type II cytoskeletal 1

3848 Homo sapiens
16678 Mus musculus
281266 Bos taurus
300250 Rattus norvegicus
444857 Canis lupus familiaris
100049664 Sus scrofa
738375 Pan troglodytes
100353415 Oryctolagus cuniculus
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