anti-D-Dopachrome Tautomerase (DDT) Antibodies

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. Additionally we are shipping D-Dopachrome Tautomerase Kits (29) and D-Dopachrome Tautomerase Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DDT 13202 O35215
DDT 1652 P30046
DDT 29318 P80254
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Top anti-D-Dopachrome Tautomerase Antibodies at

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DDT Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Liver 100 μL 2 to 3 Days
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ICC, IHC (p), ELISA, WB Western blot analysis of DDT using anti- DDT antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions. Lane: Recombinant Human DDT Protein 0.5ng After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- DDT antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for DDT at approximately 15KD. The expected band size for DDT is at 15KD. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using DDT, antibody at 1:100 dilution. WB Image Rat tissue extract (50 μg) was separated by 15% SDS-PAGE, and the membrane was blotted with DDT antibody [N1C3] , diluted at 1:500. 100 μL 3 to 4 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Liver Tissue; Lane2: Human Hela Cells. 100 μg 15 to 18 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Pancreas Tissue; Lane3: Mouse Lung Tissue. 100 μg 13 to 16 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated IHC (p), WB   100 μg 4 to 6 Days

Top referenced anti-D-Dopachrome Tautomerase Antibodies

  1. Cow (Bovine) Polyclonal DDT Primary Antibody for WB - ABIN2782455 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

  2. Human Monoclonal DDT Primary Antibody for ELISA, WB - ABIN560588 : Hiyoshi, Konishi, Uemura, Matsuzaki, Tsukamoto, Sugimoto, Takeda, Dakeshita, Kitayama, Takami, Sawachika, Kido, Arisawa: D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride. in Toxicology 2008 (PubMed)

  3. Human Polyclonal DDT Primary Antibody for IHC (p), WB - ABIN5576493 : Yoshihisa, Rehman, Kondo, Shimizu: Role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 (PubMed)

More Antibodies against D-Dopachrome Tautomerase Interaction Partners

Mouse (Murine) D-Dopachrome Tautomerase (DDT) interaction partners

  1. TWEAK upregulates CD74 and its ligands MIF and DDT in renal tubular cells.

  2. cardiomyocyte secretion of DDT has important autocrine/paracrine effects during ischemia-reperfusion that protect the heart against injury

  3. These data point to a potential involvement of D-dopachrome tautomerase activity in the mature mouse brain, and suggest some functional and evolutionary relationship between innate immunity and tautomerization of D-dopachrome in mammalian species

  4. These data indicate that D-DT is a MIF-like cytokine.

Human D-Dopachrome Tautomerase (DDT) interaction partners

  1. results show that the minor allele frequency of rs755622 and expression of DDT are significantly increased in males for MS subjects and this minor allele variant can significantly upregulate DDT expression for males but not females, which suggests that the regulation of DDT expression level by rs755622 can affect MS progression in males.

  2. D-dopachrome tautomerase transcription may be regulated in a cell-dependent manner, and was enhanced by AMPK activation in SGBS adipocytes through inhibiting the mTOR signaling

  3. The knockdown of D-DT and MIF, individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor.

  4. These results have implications for the manner in which D-DT and MIF compete with each other for binding to the CD74 receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF binding and activation through CD74.

  5. Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF, and knockdown of DDT and MIF in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF and DDT are required for their negative regulatory role in p53 and their tumor-promoting functions.

  6. DDT was increased in burn patients.

  7. Gene expression level of DDT is significantly higher in AD patients when compared to normal controls.

  8. High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury.

  9. Both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival.

  10. findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation.

  11. D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators

  12. DDT acts on adipocytes to regulate lipid metabolism through AMPK and/or PKA pathway(s) and improves glucose intolerance caused by obesity.

  13. These data indicate that D-DT is a MIF-like cytokine.

  14. D-DT-dependent beta-catenin stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin-mediated transcription in these cells

  15. role of tautomerase active site of macrophage migration inhibitory factor as a potential target for discovery of novel anti-inflammatory agents

  16. DDT is for the first time demonstrated in the skin and can be related to inflammation, and its covariation with MIF strengthens this observation.

  17. D-dopachrome tautomerase (D-DT) and macrophage migration inhibitory factor, individually and additively, promote vascular endothelial growth factor and CXCL8 expression in human lung adenocarcinoma cell lines.

D-Dopachrome Tautomerase (DDT) Antigen Profile

Protein Summary

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.

Gene names and symbols associated with DDT

  • D-dopachrome tautomerase L homeolog (ddt.L) antibody
  • D-dopachrome tautomerase (DDT) antibody
  • D-dopachrome tautomerase (ddt) antibody
  • D-dopachrome tautomerase (Ddt) antibody
  • D-dopachrome tautomerase S homeolog (ddt.S) antibody
  • C78655 antibody
  • DDCT antibody
  • ddt antibody
  • ddt-a antibody
  • ddt-b antibody
  • wu:fb49f11 antibody
  • zgc:86714 antibody

Protein level used designations for DDT

D-dopachrome decarboxylase-B , D-dopachrome tautomerase-B , D-dopachrome decarboxylase , D-dopachrome tautomerase , D-dopachrome decarboxylase-A , D-dopachrome tautomerase-A , phenylpyruvate tautomerase II , dopachrome isomerase , LOW QUALITY PROTEIN: D-dopachrome decarboxylase

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13202 Mus musculus
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550015 Xenopus (Silurana) tropicalis
416937 Gallus gallus
447275 Xenopus laevis
1652 Homo sapiens
29318 Rattus norvegicus
100155535 Sus scrofa
100359341 Oryctolagus cuniculus
100726700 Cavia porcellus
100053419 Equus caballus
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