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D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. Additionally we are shipping D-Dopachrome Tautomerase Kits (25) and D-Dopachrome Tautomerase Proteins (16) and many more products for this protein.
Showing 10 out of 76 products:
Human Monoclonal DDT Primary Antibody for ELISA, WB - ABIN560588
Hiyoshi, Konishi, Uemura, Matsuzaki, Tsukamoto, Sugimoto, Takeda, Dakeshita, Kitayama, Takami, Sawachika, Kido, Arisawa: D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride. in Toxicology 2008
Human Polyclonal DDT Primary Antibody for IHC (p), WB - ABIN5576493
Yoshihisa, Rehman, Kondo, Shimizu: Role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016
Cow (Bovine) Polyclonal DDT Primary Antibody for WB - ABIN2782455
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
The knockdown of D-DT and MIF (show AMH Antibodies), individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor.
These results have implications for the manner in which D-DT and MIF (show AMH Antibodies) compete with each other for binding to the CD74 (show CD74 Antibodies) receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF (show AMH Antibodies) binding and activation through CD74 (show CD74 Antibodies).
Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF (show AMH Antibodies), and knockdown of DDT and MIF (show AMH Antibodies) in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF (show AMH Antibodies) and DDT are required for their negative regulatory role in p53 (show TP53 Antibodies) and their tumor-promoting functions.
DDT was increased in burn patients.
Gene expression level of DDT is significantly higher in AD patients when compared to normal controls.
High MIF-2 (show CENPC1 Antibodies) levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury.
Both p53 (show TP53 Antibodies) wildtype and mutant human lung adenocarcinoma tumors rely on MIF (show AMH Antibodies) family members for maximal cell growth and survival.
findings identify DDT as a functionally redundant but more potent cytokine to MIF (show AMH Antibodies) in cancer and suggest that current attempts to inhibit MIF (show AMH Antibodies) signaling may fail because of DDT compensation.
D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 (show IL6 Antibodies) expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators
DDT acts on adipocytes to regulate lipid metabolism through AMPK (show PRKAA1 Antibodies) and/or PKA pathway(s) and improves glucose intolerance caused by obesity.
cardiomyocyte secretion of DDT has important autocrine/paracrine effects during ischemia-reperfusion that protect the heart against injury
These data point to a potential involvement of D-dopachrome tautomerase activity in the mature mouse brain, and suggest some functional and evolutionary relationship between innate immunity and tautomerization of D-dopachrome in mammalian species
These data indicate that D-DT is a MIF (show MIF Antibodies)-like cytokine.
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.
, D-dopachrome decarboxylase-A
, D-dopachrome tautomerase-A
, D-dopachrome decarboxylase-B
, D-dopachrome tautomerase-B
, D-dopachrome tautomerase
, dopachrome isomerase
, phenylpyruvate tautomerase II