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In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. Additionally we are shipping DAZAP1 Proteins (6) and DAZAP1 Kits (4) and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal DAZAP1 Primary Antibody for IHC, WB - ABIN2776659
Goina, Skoko, Pagani: Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. in Molecular and cellular biology 2008
Show all 3 Pubmed References
Human Polyclonal DAZAP1 Primary Antibody for ICC, IF - ABIN4304345
Sutherland, Sobinoff, Fraser, Redgrove, Siddall, Koopman, Hime, McLaughlin: RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis. in Journal of cellular physiology 1970
Data indicate that DAZAP1 exerts a suppressive effect on cox6c (show COX6C Antibodies) pre-mRNA splicing and reduced DAZAP1 expression increases the COX6C protein (show COX6C Antibodies) level, leading to cell growth retardation.
The splicing activator DAZAP1 integrates splicing control into MEK (show MAP2K1 Antibodies)/Erk (show EPHB2 Antibodies)-regulated cell proliferation and migration.
this study reports the mapping of a 42-amino acid segment (N42) at the N-terminus of DAZAP1 that is both necessary and sufficient for its transcription-dependent nuclear localization.
Data show that hnRNPA1 (show HNRNPA1 Antibodies)/A2, HuR (show ELAVL1 Antibodies) and DAZAP1 splicing factors and DHX36 (show DHX36 Antibodies) RNA helicase (show DDX46 Antibodies) bind to the ISE, with hnRNPA1 (show HNRNPA1 Antibodies) acting negatively and DAZAP1 positively on splicing selection
DAZAP1 can regulate mRNA translation.
data suggest that MEF2D (show MEF2D Antibodies)/DAZAP1 and/or DAZAP1/MEF2D (show MEF2D Antibodies) contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D (show MEF2D Antibodies) and DAZAP1
This study shows expression patterns of DAZAP1 in human corpus luteum cells and demonstrates the in vivo interaction of DAZ-like protein (DAZL (show DAZL Antibodies)) with DAZAP1.
DAZ cannot bind simultaneously to DAZAP1 and poly(A)-binding protein (PABP), and suggest that the phosphorylation-induced dissociation of DAZ and DAZAP1 may allow the former to stimulate translation by interacting with PABP.
The binding of the splicing factors hnRNPA1/A2 and DAZAP1 is the primary determinant of T6 BRCA1 exon 18 exclusion.
The results suggest that DAZAP1 is a component of complexes that are crucial for the degradation and silencing of mRNA.
Identification of Crem (show CREM Antibodies), Crisp2 (show CRISP2 Antibodies) and Pot1a (show POT1 Antibodies) as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes.
The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis.
Identification of RNA consensus sequences required for binding to DAZAP1.
Dynamic changes in intranuclear and subcellular localizations of DAZAP1 during spermatogenesis have been studied.
DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice.
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.
DAZ associated protein 1
, DAZ-associated protein 1
, deleted in azoospermia-associated protein 1
, proline-rich Vg1 mRNA-binding protein