DCP2 Decapping Enzyme Homolog (S. Cerevisiae) Proteins (DCP2)

The protein encoded by DCP2 is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). Additionally we are shipping DCP2 Antibodies (58) and many more products for this protein.

list all proteins	Gene Name	GeneID	UniProt
	DCP2	70640	Q9CYC6
	DCP2	167227	Q8IU60
Rat DCP2	DCP2	291604

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Showing 6 out of 6 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3137057	Insect Cells	Mouse	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN3092053	Insect Cells	Human	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN5711505	Escherichia coli (E. coli)	Human	His tag	100 μg	Log in to see	11 Days	$411.40	Details
ABIN5714416	Yeast	Human	His tag	100 μg	Log in to see	8 to 11 Days	$484.00	Details
ABIN1351208	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN1635934	Yeast	Orang-Utan	His tag	1 mg	Log in to see	60 to 71 Days	$3,059.83	Details

DCP2 Proteins by Origin and Source

Origin	Expressed in	Conjugate
Mouse (Murine)
Human	, , ,	,

More product categories related to DCP2 Protein

More Proteins for DCP2 Decapping Enzyme Homolog (S. Cerevisiae) (DCP2) Interaction Partners

Mouse (Murine) DCP2 Decapping Enzyme Homolog (S. Cerevisiae) (DCP2) interaction partners

results suggest miR (show MLXIP Proteins)-141-3p/200a-3p may be involved in post-transcriptional repression of Dcp2 expression during renal development
ERK (show EPHB2 Proteins)-phosphorylated Dcp1a (show DCP1A Proteins) enhances its interaction with the decapping enzyme (show DCP1A Proteins) Dcp2 during early differentiation of 3T3-L1 cells.
Recruitment of DCP1A (show DCP1A Proteins) and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.
The results showed that DCP1A (show DCP1A Proteins) and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition.
In this study the increase in Irf-7 (show IRF7 Proteins) mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 (show IRF7 Proteins) mRNA, suggesting that Dcp2 normally modulates Irf-7 (show IRF7 Proteins) mRNA stability.
Like Dcp2, Nudt16 (show NUDT16 Proteins) also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.

Human DCP2 Decapping Enzyme Homolog (S. Cerevisiae) (DCP2) interaction partners

Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation.
The data indicates that DCP2 activation by DCP1 (show ACE Proteins) occurs preferentially on the EDC4 (show EDC4 Proteins) scaffold, which may serve to couple DCP2 activation by DCP1 (show ACE Proteins) with 5'-to-3' mRNA degradation by XRN1 (show XRN1 Proteins) in human cells.
Data show that Y14 (show RBM8A Proteins) interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains.
PNRC2 (show PNRC2 Proteins) acts in synergy with Dcp1a (show DCP1A Proteins) to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a (show DCP1A Proteins) and Dcp2.
Like Dcp2, Nudt16 (show NUDT16 Proteins) also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
an mRNA decapping enzyme (show DCPS Proteins) demonstrated to contain intrinsic decapping activity
Human Dcp2 is a catalytically active mRNA decapping enzyme (show DCPS Proteins) that localizes to the cytoplasm
LSm1 (show LSM1 Proteins)-7 proteins colocalize with DCP1 (show ACE Proteins),DCP2 and Xrn1 (show XRN1 Proteins) in cytoplasmic foci
These data support the novel notion of the association between Ro52 (show TRIM21 Proteins) with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.

DCP2 Protein Profile

Protein Summary

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with DCP2

mRNA-decapping enzyme 2 (CpipJ_CPIJ019463)
mRNA-decapping enzyme 2 (PTRG_05936)
mRNA-decapping enzyme 2 (dcp2)
mRNA-decapping enzyme 2 (MCYG_05106)
mRNA-decapping enzyme 2 (MGYG_07617)
hypothetical protein (PGTG_03310)
mRNA-decapping enzyme 2 (Tsp_04018)
decapping mRNA 2 (dcp2)
decapping mRNA 2 (DCP2)
decapping mRNA 2 (Dcp2)

2410015D23Rik protein
5730537H01Rik protein
AL118268 protein
DDBDRAFT_0185453 protein
DDBDRAFT_0252811 protein
DDB_0185453 protein
DDB_0252811 protein
NUDT20 protein
RGD1562909 protein

Protein level used designations for DCP2

mRNA-decapping enzyme 2 , DCP2 decapping enzyme homolog , m7GpppN-mRNA hydrolase , hDpc , nudix (nucleoside diphosphate linked moiety X)-type motif 20

GENE ID	SPECIES
6054129	Culex quinquefasciatus
6344191	Pyrenophora tritici-repentis Pt-1C-BFP
8624030	Dictyostelium discoideum AX4
9230993	Arthroderma otae CBS 113480
10025613	Arthroderma gypseum CBS 118893
10538062	Puccinia graminis f. sp. tritici CRL 75-36-700-3
10904275	Trichinella spiralis
100195938	Salmo salar
489086	Canis lupus familiaris
70640	Mus musculus
100127054	Pongo abelii
167227	Homo sapiens
291604	Rattus norvegicus

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