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DDX39 encodes a member of the DEAD box protein family.
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Cow (Bovine) Polyclonal DDX39 Primary Antibody for WB - ABIN2775205
Pryor, Tung, Yang, Kapadia, Chang, Johnson: Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. in Nucleic acids research 2004
Show all 2 Pubmed References
The expression of DDX39 in gemcitabine-sensitive KLM1 and -resistant KLM1-R cells was compared.
Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 (show DDX39B Antibodies) and URH49
Regulation of URH49 mRNA expression and comparison with the related UAP56 (show DDX39B Antibodies) RNA helicase.
DDX39B and its paralog DDX39A regulate androgen receptor (show AR Antibodies) splice variant AR-V7 generation
DDX39A is a potential biomarker for unfavorable neuroblastoma (show ARHGEF16 Antibodies)
The protein levels of DDX39 were found to be higher in malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells.
Results suggest that DDX39 is a suppressor of invasion and loss of its function predicts disease progression in bladder cancers.
-dependent RNA helicase (show DDX46 Antibodies) DDX39 has a role in poor prognosis of patients with gastrointestinal stromal tumor
Requirement of DDX39 DEAD box RNA helicase (show DDX5 Antibodies) for genome integrity and telomere protection
UAP56 (show DDX39B Antibodies) and URH49 exhibit an intrinsic CRM1 (show XPO1 Antibodies)-independent nucleocytoplasmic shuttling
Data show that the two closely related RNA helicases UAP56 (show DDX39B Antibodies) and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps.
Using a UL69 viral mutant that is unable to bind UAP56 (show DDX39B Antibodies) and URH49, the authors demonstrated that UL69's interaction with UAP56 (show DDX39B Antibodies) or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant.
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternatively spliced transcript variants encoding different isoforms have been found.
ATP-dependent RNA helicase DDX39
, ATP-dependent RNA helicase DDX39A
, DEAD box protein 39
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39
, UAP56-related helicase, 49 kDa
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 transcript
, nuclear RNA helicase URH49
, nuclear RNA helicase, DECD variant of DEAD box family
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39a
, Eukaryotic initiation factor 4a