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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.
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DHX32 is an upstream regulator for beta-catenin (show CTNNB1 ELISA Kits), which promotes the activity of beta-catenin (show CTNNB1 ELISA Kits) to upregulate expression of VEGFA (show VEGFA ELISA Kits) in colorectal cancer cells. Depletion of DHX32 expression suppressed colorectal cancer tumor angiogenesis and tumor growth.
Structural characterization and expression of the DDX32 gene. Expression studies show that DDX32 is widespread but specifically down-regulated in acute lymphoblastic leukemias and might play a role in normal and/or abnormal lymphopoiesis.
cloned DHX32 proximal promoter and identified a 218bp fragment containing two potential binding sites for the transcription factor nuclear factor of activated T cells (NF-AT (show NFATC3 ELISA Kits))
These results suggest that DHX32 is a putative RNA helicase (show DDX41 ELISA Kits) that might be involved in regulating nuclear and mitochondrial gene expression.
dysregulated expression of DHX32 might lead to as of yet unknown changes in mitochondrial homeostasis manifested by cytoplasmic redistribution of the molecular chaperon Hsp60 (show HSPD1 ELISA Kits)
In peripheral blood lymphocytes, a correlation between DHX32 and c-FLIP (show CFLAR ELISA Kits) short expression was detected in response to different T-cell activation stimuli. Results suggest DHX32 involvement in regulating T-cell response to apoptotic stimuli.
DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation.
electron microscope immunocytochemistry detected the presence of Dhx32 in the mitochondria of hepatocytes
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined.
DEAH (Asp-Glu-Ala-His) box polypeptide 32
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32-like
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
, putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32-like
, DEAD/H box 32
, DEAD/H helicase-like protein 1
, DEAD/H helicase-like protein-1
, DEAH box protein 32
, putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
, helicase DDX32