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DEK encodes a protein with one SAP domain. Additionally we are shipping DEK Antibodies (64) and DEK Kits (7) and many more products for this protein.
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High DEK expression is associated with cervical cancer tumorigenesis and metastasis.
The results of the present study demonstrated that EMT (show ITK Proteins) of colorectal carcinoma cells was partially mediated by DEK, which likely affected the invasive ability of colorectal carcinoma cells. In addition, cell proliferation and apoptosis were susceptible to DEK silencing.
RNA-sequencing proved to be a valuable tool for the detection of a fusion of genes DEK and NUP214 in a leukemia that showed cryptic cytogenetic rearrangement of chromosome band 9q34.
DEK overexpression enhanced carcinogenesis, including field cancerization, in OSCC by stimulating the G1 /S phase transition and promoting DNA replication.
DEK and LCMR1 (show MED19 Proteins) were demonstrated to cooperate in the inhibition of apoptosis in lung cancer cells.
High DEK expression is associated with breast cancer angiogenesis .
our study indicates that DEK expression is required for tumorigenesis and metastasis of hepatocellular carcinoma
High DEK expression is associated with melanoma progression.
DEK correlates with IL6 expression in HPV16+/p16+ oropharyngeal squamous cell carcinomas (OPSCC).
data support a scenario whereby overexpression of the human DEK oncogene reprograms keratinocyte metabolism to fulfill energy and macromolecule demands required to enable and sustain cancer cell growth
Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth.
Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage.
DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation
Studies demonstrate that DEK overexpression, due in part to Ron (show MST1R Proteins) receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas.
data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector
DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest.
The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein.
DEK is a neuroblastoma (show ARHGEF16 Proteins) tumor antigen.
Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes.
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
DEK oncogene (DNA binding)
, protein DEK
, DEK oncogene