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DEK encodes a protein with one SAP domain. Additionally we are shipping DEK Antibodies (60) and DEK Kits (5) and many more products for this protein.
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our study indicates that DEK expression is required for tumorigenesis and metastasis of hepatocellular carcinoma
High DEK expression is associated with melanoma progression.
DEK correlates with IL6 expression in HPV16+/p16+ oropharyngeal squamous cell carcinomas (OPSCC).
data support a scenario whereby overexpression of the human DEK oncogene reprograms keratinocyte metabolism to fulfill energy and macromolecule demands required to enable and sustain cancer cell growth
Decreased DEK expression in plasma cells suggests a potential role of this gene in plasma cell development and lack of detectable DEK protein by IHC could be used as a biomarker for normal and malignant plasma cells
Our data indicated DEK plays multiple roles to facilitate tumor growth and maintenance. It can be used as a potential target for astrocytic tumor diagnosis and gene therapy.
High DEK expression is associated with pancreatic ductal adenocarcinoma.
AP-2a is an important transcription factor of DEK expression, which is correlated with the methylation level of the DEK core promoter in hepatocellular carcinoma .
miR (show MLXIP Proteins)-592 targets DEK transcript and suppresses hepatocellular carcinoma cell growth
Results find that DEK binds to transcription start sites with a dual role in activation and repression of highly and ubiquitously expressed genes.
Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage.
DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation
Studies demonstrate that DEK overexpression, due in part to Ron (show MST1R Proteins) receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas.
data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector
DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest.
The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein.
DEK is a neuroblastoma (show ARHGEF16 Proteins) tumor antigen.
Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes.
Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
DEK oncogene (DNA binding)
, protein DEK
, DEK oncogene