anti-DIX Domain Containing 1 (DIXDC1) Antibodies

Human DIX Domain Containing 1 (DIXDC1) interaction partners

1. High DIXDC1 expression is associated with Growth and Invasion of Gastric Cancer.

2. these results demonstrate that DIXDC1 promotes the growth of acute myeloid leukemia cells, possibly through upregulating the Wnt/beta-catenin signaling pathway

3. DIXDC1 silencing inhibited cell proliferation, invasion, and Wnt signaling in retinoblastoma cell lines. DIXDC1 was identified as a target gene of miR-186

4. MiR-539 inhibits glioma cell proliferation and invasion by targeting DIXDC1.

5. DIXDC1 might participate in the development of glioma.

6. Overexpression of DIXDC1 correlates with enhanced cell growth and poor prognosis in human pancreatic ductal adenocarcinoma.

7. found that DIXDC1 could promote cell proliferation via modulating cell cycle progression and PI3K/AKT signaling pathway in NHLs

8. Taken together, our results suggest that DIXDC1 plays an important role in regulating prostate cancer cell proliferation and invasion. Targeting DIXDC1 by miR-1271 may be a promising therapeutic strategy for prostate cancer.

9. Downregulated expression of DIXDC1 is associated with hepatocellular carcinoma.

10. DIXDC1 was overexpressed in gastric cancer and correlated with poor prognosis.

11. DIXDC1 is associated with stage and prognosis in non-small cell lung cancer, and may promote invasion and migration through PI3K-AKT/AP-1-dependent activation of metalloproteinases

12. DIXDC1 depletion results in upregulation of Snail1 in a FAK-dependent manner, leading to increased cell invasion. MARK1 phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.

13. Transgenic DIXDC1 might contribute to pathophysiology underlying abnormal behaviors in schizophrenia and other major psychiatric disorders in mice.

14. a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s).

15. This study reveal that Dixdc1 integrates DISC1 into Wnt-GSK3beta/beta-catenin-dependent and -independent signaling pathways during cortical development and further delineate how DISC1 contributes to neuropsychiatric disorders.

16. Wnt/beta-catenin pathway activation might upregulate DIXDC1 through a post-translational mechanism by inhibiting the ubiquitin-mediated degradation of the DIXDC1 protein.

17. KIAA1735 maps to human chromosome 11q23.1 and encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain

18. Ccd1 inhibits Axin-mediated JNK activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MEKK1 binding and the other via direct sequestration of MEKK4.

19. Thus, our data provide the first evidence that l-DIXDC1 may act as a novel branching component in the Wnt signaling pathway targeting both beta-catenin-TCF complex for gene expression and cytoskeleton for regulating dynamics of actin filaments.

20. DIXDC1 might play an important role during neurogenesis, overexpression of DIXDC1 in embryonic carcinoma P19 cells promoted neuronal differentiation, and inhibited gliogenesis induced by retinoic acid.

Mouse (Murine) DIX Domain Containing 1 (DIXDC1) interaction partners

1. These findings suggest a novel regulatory mechanism by which mCcd1 modulates Wnt signaling through auto-inhibition of dynamic head-to-tail homopolymerization.

2. DIXDC1 is a regulator of cortical dendrite and synaptic development.

3. Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 in major mental illnesses.

4. crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution

5. a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s).

6. DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain

7. mouse Ccd1 functions as a positive regulator of the Wnt/beta-catenin pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt signaling molecules in the embryonic and adult brain.

Zebrafish DIX Domain Containing 1 (DIXDC1) interaction partners

1. These results indicate that Ccd1 is a novel positive regulator in this Wnt signaling pathway during zebrafish neural patterning.