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The protein encoded by DIXDC1 is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. Additionally we are shipping DIX Domain Containing 1 Antibodies (50) and DIX Domain Containing 1 Proteins (8) and many more products for this protein.
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DIXDC1 silencing inhibited cell proliferation, invasion, and Wnt signaling in retinoblastoma cell lines. DIXDC1 was identified as a target gene of miR-186
MiR (show MLXIP ELISA Kits)-539 inhibits glioma cell proliferation and invasion by targeting DIXDC1.
DIXDC1 might participate in the development of glioma.
Overexpression of DIXDC1 correlates with enhanced cell growth and poor prognosis in human pancreatic ductal adenocarcinoma.
found that DIXDC1 could promote cell proliferation via modulating cell cycle progression and PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway in NHLs
Taken together, our results suggest that DIXDC1 plays an important role in regulating prostate cancer cell proliferation and invasion. Targeting DIXDC1 by miR-1271 may be a promising therapeutic strategy for prostate cancer.
Downregulated expression of DIXDC1 is associated with hepatocellular carcinoma.
DIXDC1 was overexpressed in gastric cancer and correlated with poor prognosis.
DIXDC1 is associated with stage and prognosis in non-small cell lung cancer, and may promote invasion and migration through PI3K (show PIK3CA ELISA Kits)-AKT (show AKT1 ELISA Kits)/AP-1 (show FOSB ELISA Kits)-dependent activation of metalloproteinases
DIXDC1 depletion results in upregulation of Snail1 (show SNAI1 ELISA Kits) in a FAK (show PTK2 ELISA Kits)-dependent manner, leading to increased cell invasion. MARK1 (show MARK1 ELISA Kits) phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.
DIXDC1 is a regulator of cortical dendrite and synaptic development.
Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 (show DISC1 ELISA Kits) in major mental illnesses.
crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution
a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s).
DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain
mouse Ccd1 functions as a positive regulator of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt (show WNT2 ELISA Kits) signaling molecules in the embryonic and adult brain.
These results indicate that Ccd1 is a novel positive regulator in this Wnt (show WNT2 ELISA Kits) signaling pathway during zebrafish neural patterning.
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not.
DIX domain containing 1
, coiled-coil protein DIX1
, DIX domain-containing protein 1
, DIX domain-containing protein 1-A
, coiled-coil DIX 1
, coiled-coil protein DIX1-A