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encodes a protein that is a member of the dickkopf family.
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Human Monoclonal Primary Antibody for FACS, ELISA - ABIN1724727
Persson, Rosenquist, Sommarin: Identification of a novel calreticulin isoform (Crt2) in human and mouse. in Gene 2002
Show all 3 Pubmed References
Human Monoclonal Primary Antibody for FACS, IHC - ABIN1098142
Du, Kataoka, Sakaguchi, Abarzua, Than, Sonegawa, Makino, Shimizu, Huh: Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis. in Experimental dermatology 2011
Show all 2 Pubmed References
Human Polyclonal Primary Antibody for IHC (p), WB - ABIN388355
Tsuji, Nozaki, Miyazaki, Sakaguchi, Pu, Hamazaki, Iijima, Namba: Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. in Biochemical and biophysical research communications 2001
Show all 3 Pubmed References
Human Polyclonal Primary Antibody for IHC (p), IHC - ABIN257865
Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. in Gene 1999
this study demonstrated the anti-glioma effect of Ad-SGE-REIC, which may represent a promising strategy for the treatment of malignant glioma.
DKK3 is a novel and promising molecular target for keloid treatment.
This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells.
Study shows a reduced expression of DKK3 in adrenocortical carcinoma potentially contributing to adrenal dedifferentiation and/or progression of malignancy.
Low DKK3 expression is associated with gastric cancer.
studies decoding the underlying molecular mechanisms of DKK3-mediated effects may help to identify novel targeted therapies for this clinically highly relevant breast cancer subtype
REIC/Dkk-3 could be involved early in squamous cell carcinoma development and have inhibitory effect on the development of SCC
Administration of DKK3 protein and peripheral blood mononuclear cell transplantation synergistically enhanced anticancer immunological effects against pancreatic cancer cells.
Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH (show XDH Antibodies) expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis.
High DKK3 expression is associated with malignant progression of oral submucous fibrosis.
The data of this study suggest that Dkk3 is an agonist of Wnt signaling, and the ability of transgenic expression of Dkk3 to compensate for the decrease in Dkk3 expression in AD mice, reverse dysfunctional Wnt signaling, and partially inhibit the pathological development of AD suggests that Dkk3 could serve as a therapeutic target for the treatment of AD.
DKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.
DKK3 deficiency accelerated atherosclerosis and delayed re-endothelialization and exacerbated neointima formation.
These results suggest that Dkk3 has pleiotropic roles for a secretory glycoprotein that acts primarily in the gastrointestinal tract, thymus, endocrine and reproductive organs of the mouse.
these data suggest that downregulation of tubular beta-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis.
Dkk3 expression was seen in the superficial zone of the mandibular condyle cartilage.
Studied role of Dkk3 on the pathogenesis of familial dilated cardiomyopathy, and whether and how Dkk3 interferes with Wnt (show WNT2 Antibodies) signaling in heart tissues.
the soluble DKK3 protein might be a promising new agent for the improvement of current protocols for the directed differentiation of pluripotent and multipotent stem cells
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 (show ATF6 Antibodies) signaling and myocardin (show MYOCD Antibodies) expression.
Date indicate that B1 cells have a better survival and proliferation capacity in the absence of Dickkopf-3 protein (DKK3).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
, RIG-like 7-1
, dickkopf 3 homolog
, dickkopf homolog 3
, dickkopf-related protein 3
, regulated in glioma
, dickkopf 3
, lens fiber protein CLFEST4