anti-DKK3 Antibodies

encodes a protein that is a member of the dickkopf family. Additionally we are shipping DKK3 Kits (38) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
27122 Q9UBP4
50781 Q9QUN9
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Top anti-DKK3 Antibodies at

Showing 10 out of 184 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184709 staining (2µg/ml) of HEK293 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A549, using DKK3, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
Mouse Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with DKK3 antibody (N-term) (ABIN388355), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with DKK3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using DKK3 mAb against human DKK3 recombinant protein. (Expected MW is 54.4 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunohistochemical analysis of paraffin-embedded brain tissues using DKK3 mouse mAb with DAB staining. 100 μg Log in to see 3 to 4 Days
Human Mouse Un-conjugated ELISA, FACS, IHC, IHC (p) 100 μg Log in to see 11 to 14 Days

Top referenced anti-DKK3 Antibodies

  1. Human Monoclonal Primary Antibody for FACS, ELISA - ABIN1724727 : Persson, Rosenquist, Sommarin: Identification of a novel calreticulin isoform (Crt2) in human and mouse. in Gene 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal Primary Antibody for IHC (p), WB - ABIN388355 : Tsuji, Nozaki, Miyazaki, Sakaguchi, Pu, Hamazaki, Iijima, Namba: Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal Primary Antibody for FACS, IHC - ABIN1098142 : Du, Kataoka, Sakaguchi, Abarzua, Than, Sonegawa, Makino, Shimizu, Huh: Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis. in Experimental dermatology 2011 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Primary Antibody for IHC (p), ELISA - ABIN544529 : Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. in Gene 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against DKK3 Interaction Partners

Human DKK3 interaction partners

  1. These observations are consistent with a model in which the loss of Dkk-3 in prostate cancer leads to increased secretion of TGFBI and ECM-1, which have tumor-promoting and tumor-protective roles, respectively

  2. Dickkopf-3 (DKK3) is a heat shock transcription factor 1 protein (HSF1) effector that modulates the pro-tumorigenic behaviour of cancer-associated fibroblasts (CAFs), and DKK3 orchestrates a concomitant activation of beta-catenin and YAP oncogene protein (YAP)/tafazzin protein (TAZ).

  3. DKK3 altered the atherosclerotic plaque content by increasing smooth muscle cell differentiation/numbers and reducing vascular inflammation.

  4. These findings suggested that the down-regulated REIC expression might be involved in lung carcinogenesis due to its promoter methylation

  5. the results indicate that TNFalpha downregulates REIC/Dkk3 expression in normal skin keratinocytes.

  6. These results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in osteosarcoma, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease.

  7. DKK3 might contribute to cellular proliferation, invasion, migration, and tumor cell survival in head and neck/oral squamous cell carcinoma cells through a mechanism other than the canonical Wnt signaling pathway, which might be attributed to PI3K-Akt signaling

  8. this study demonstrated the anti-glioma effect of Ad-SGE-REIC, which may represent a promising strategy for the treatment of malignant glioma.

  9. DKK3 is a novel and promising molecular target for keloid treatment.

  10. This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells.

  11. dickkopf-3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers.

  12. Study shows a reduced expression of DKK3 in adrenocortical carcinoma potentially contributing to adrenal dedifferentiation and/or progression of malignancy.

  13. Low DKK3 expression is associated with gastric cancer.

  14. studies decoding the underlying molecular mechanisms of DKK3-mediated effects may help to identify novel targeted therapies for this clinically highly relevant breast cancer subtype

  15. REIC/Dkk-3 could be involved early in squamous cell carcinoma development and have inhibitory effect on the development of SCC

  16. Administration of DKK3 protein and peripheral blood mononuclear cell transplantation synergistically enhanced anticancer immunological effects against pancreatic cancer cells.

  17. Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis.

  18. High DKK3 expression is associated with malignant progression of oral submucous fibrosis.

  19. The data indicated that Dkk3 has a novel role in modulating macropinocytotic and autophagic pathways, a distinct function other than a Wnt antagonist.

  20. we observed Dickkopf-related protein 3 (DKK3) as a direct target of miR-25 in vitro. Upregulation of DKK3 partially attenuated the oncogenic effect of miR-25 on melanoma cells. Ectopic expression of miR-25 in melanoma cells induced beta-catenin accumulation in nuclear and inhibited TCF4 (T cell factor 4) activity, as well as the expression of c-Myc and Cyclin D1.

Mouse (Murine) DKK3 interaction partners

  1. DKK3 altered the atherosclerotic plaque content by increasing smooth muscle cell differentiation/numbers and reducing vascular inflammation.

  2. findings suggest that Dkk3 may be used as diagnostic marker and as therapeutic target for age-related muscle atrophy, and reveal a distinct transcriptional control of Fbxo32 and Trim63

  3. The data of this study suggest that Dkk3 is an agonist of Wnt signaling, and the ability of transgenic expression of Dkk3 to compensate for the decrease in Dkk3 expression in AD mice, reverse dysfunctional Wnt signaling, and partially inhibit the pathological development of AD suggests that Dkk3 could serve as a therapeutic target for the treatment of AD.

  4. DKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt/beta-catenin pathway.

  5. DKK3 deficiency accelerated atherosclerosis and delayed re-endothelialization and exacerbated neointima formation.

  6. These results suggest that Dkk3 has pleiotropic roles for a secretory glycoprotein that acts primarily in the gastrointestinal tract, thymus, endocrine and reproductive organs of the mouse.

  7. these data suggest that downregulation of tubular beta-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis.

  8. Dkk3 expression was seen in the superficial zone of the mandibular condyle cartilage.

  9. Studied role of Dkk3 on the pathogenesis of familial dilated cardiomyopathy, and whether and how Dkk3 interferes with Wnt signaling in heart tissues.

  10. the soluble DKK3 protein might be a promising new agent for the improvement of current protocols for the directed differentiation of pluripotent and multipotent stem cells

  11. DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression.

  12. Date indicate that B1 cells have a better survival and proliferation capacity in the absence of Dickkopf-3 protein (DKK3).

  13. DKK3 acts as a cardioprotective regulator of pathological cardiac hypertrophy

  14. This is the first report of role of DKK3 in the testis and DKK3 mediated regulation of spermatogenesis via WNT-4/beta-CATENIN modulation.

  15. Findings suggest that Dkk-3 maintains the structural integrity of the prostate gland by limiting TGF-beta/Smad signalling.

  16. Dkk3 can act as a modifier gene in a mouse model for altered potassium channel function and suggest its potential involvement in human PA syndromes.

  17. The precise expression of the Dkk3 protein was examined by generating transgenic mice that express EGFP integrated into the Dkk3 gene in a bacterial artificial chromosome plasmid.

  18. abrogation of DKK3 function reversed tolerance, leading to eradication of tumors expressing the target antigen and to rejection of autologous skin grafts. Thus, our findings define DKK3 as a immune modulator with a crucial role for CD8 T-cell tolerance

  19. Dkk-3 is expressed in human and mouse epidermis at the interface of upper spinous layer and granular layer. REIC/Dkk-3 expression is suppressed in the regenerative and inflammative epidermis of model mice.

  20. data establish that Krm proteins are novel binding partners of Dkk3 and suggest a mechanism by which Dkk3 potentiates Wnt signaling

DKK3 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with anti-DKK3 Antibodies

  • dickkopf WNT signaling pathway inhibitor 3 (DKK3) antibody
  • dickkopf WNT signaling pathway inhibitor 3 (dkk3) antibody
  • dickkopf WNT signaling pathway inhibitor 3 S homeolog (dkk3.S) antibody
  • dickkopf WNT signaling pathway inhibitor 3 (Dkk3) antibody
  • AW061014 antibody
  • C87148 antibody
  • dkk-3 antibody
  • p29 antibody
  • Reic antibody
  • RIG antibody

Protein level used designations for anti-DKK3 Antibodies

RIG-like 5-6 , RIG-like 7-1 , dickkopf 3 homolog , dickkopf homolog 3 , dickkopf-3 , dickkopf-related protein 3 , dkk-3 , hDkk-3 , regulated in glioma , dickkopf 3 , mDkk-3 , lens fiber protein CLFEST4

27122 Homo sapiens
100144724 Xenopus (Silurana) tropicalis
100158374 Xenopus laevis
50781 Mus musculus
171548 Rattus norvegicus
664653 Sus scrofa
506627 Bos taurus
396023 Gallus gallus
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