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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3B Kits (14) and DNMT3B Proteins (6) and many more products for this protein.
Showing 10 out of 135 products:
Human Monoclonal DNMT3B Primary Antibody for ChIP, CyTOF - ABIN252478
Santoro, Li, Grummt: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. in Nature genetics 2002
Show all 97 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN151734
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
Show all 16 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for IHC (p), WB - ABIN387884
Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: Systems-level dynamic analyses of fate change in murine embryonic stem cells. in Nature 2009
Show all 13 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for ChIP, IHC - ABIN152675
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Polyclonal DNMT3B Primary Antibody for IF (p), IHC (p) - ABIN727623
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Human Monoclonal DNMT3B Primary Antibody for ChIP, WB - ABIN2668954
Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. in Molecular cancer research : MCR 2013
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Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN314552
Fűri, Sipos, Spisák, Kiszner, Wichmann, Schöller, Tulassay, Műzes, Molnár: Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status. in TheScientificWorldJournal 2014
Human Monoclonal DNMT3B Primary Antibody for WB - ABIN2668953
Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. in Nucleic acids research 2011
Mouse (Murine) Polyclonal DNMT3B Primary Antibody for WB - ABIN2668253
Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013
dnmt7 specifically methylates no tail gene in the genome
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
Alternative splice variant of DNMT3B is associated with leukemia.
these results provided a plausible link between the observed reduction of miR (show MLXIP Antibodies)-26a and MEG3 (show FAM129B Antibodies) in HCCs (show HCCS Antibodies). Together, the present study added miR (show MLXIP Antibodies)-26a/DNMT3B/MEG3 (show FAM129B Antibodies) axis to the complex mechanisms of HCC (show FAM126A Antibodies) development.
Results show that DNMT1 (show DNMT1 Antibodies) mRNA levels were significantly higher in alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma tumors compared to normal skeletal muscle. Thse data indicate that altered expression of DNMT3B plays a key role in embryonal rhabdomyosarcoma development since its silencing is able to reverse cell cancer phenotype by rescuing myogenic program.
The present study shows that DNMT3B rs2424913 promotor polymorphism represents a genetic risk factor that may play an important role in understanding the pathogenesis of chronic immune thrombocytopenia.
LMP1-mediated NF-kappaB can up-regulate DNMT3b transcription, thereby leading to relatively higher methylation intensity at PTEN CpG islands, and ultimately silencing major tumor suppressor PTEN
DNMT1 (show DNMT1 Antibodies), DNMT3A (show DNMT3A Antibodies), and DNMT3B were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (show DNMT1 Antibodies) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (show DNMT1 Antibodies) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (show DNMT1 Antibodies) A201G gene polymorphi
report the first crystal structure of the DNMT3B PWWP domain-H3K36me3 complex.
Results continue to establish ANG (show ANG Antibodies) as an oncoprotein and further reveal that ANG (show ANG Antibodies) contributes to oncogenesis by the activation of MMP2 (show MMP2 Antibodies) through modulation of DNMT3b functions.
found association between DNMT3B rs2424913 in T allele carriers with Parkinson's disease
H19 (show NCKAP1 Antibodies) might function as ceRNA (competing endogenous RNA) for miR (show MLXIP Antibodies)-29b-3p and relieve the suppression for DNMT3B, which led to EMT (show ITK Antibodies) and metastasis of bladder cancer (BC). Our findings highlight a novel mechanism of H19 (show NCKAP1 Antibodies) in progression of BC and provide H19 (show NCKAP1 Antibodies)/miR (show MLXIP Antibodies)-29b-3p/DNMT3B axis as a promising therapeutic target for BC.
The epiblast expressed epithelial markers, MUC1 (show MUC1 Antibodies) and E-CADHERIN (show CDH1 Antibodies), and the pluripotency markers, DNMT3B and CRIPTO (show TDGF1 Antibodies).
Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
The expression levels of DNMT3a (show DNMT3A Antibodies) and DNMT3b were associated with several beef quality traits.
Altogether, the authors demonstrate that Dnmt3a (show DNMT3A Antibodies) and Dnmt3b protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (show PPARG Antibodies).
a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.
Together, this study described the regulation of Chk2 (show CHEK2 Antibodies) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (show CHEK2 Antibodies) during neuronal differentiation, which is independent of its previously known function in DNA damage response.
in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation
three DNA methyltransferases, Dnmt1 (show DNMT1 Antibodies), Dnmt3a (show DNMT3A Antibodies), and Dnmt3b, have been identified. Dnmt3a (show DNMT3A Antibodies) and Dnmt3b are responsible for establishing DNA methylation (show HELLS Antibodies) patterns produced through their de novo-type DNA methylation (show HELLS Antibodies) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (show TRDMT1 Antibodies)), which is a member of the Dnmt3 family but does not possess DNA methylation (show HELLS Antibodies)
While lens epithelial cell survival requires DNMT1 (show DNMT1 Antibodies), morphologically normal lenses develop in the absence of both DNMT3A (show DNMT3A Antibodies) and DNMT3B.
Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.
a miR (show MLXIP Antibodies)-125b-DNMT3b-p53 (show TP53 Antibodies) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.
miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (show DNMT1 Antibodies), DNMT3b and SET1A (show SETD1A Antibodies) expression in hepatic stellate cells.
Loss of DNMT3B results in hypomethylation of the miR (show MLXIP Antibodies)-196b promoter and increased miR (show MLXIP Antibodies)-196b expression, which directly targets the mTORC2 (show CRTC2 Antibodies) component Rictor (show RICTOR Antibodies).
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
DNA (cytosine-5)-methyltransferase 3B
, DNA (cytosine-5-)-methyltransferase 3 beta
, DNA cytosine-5 methyltransferase 3 beta
, DNA (cytosine-5)-methyltransferase 3B-like
, DNA methyl transferase beta
, DNA methyltransferase 3B
, DNA MTase HsaIIIB
, DNA methyltransferase HsaIIIB
, DNA (cytosine-5-)-methyltransferase 3 beta, like
, DNA (cytosine-5-)-methyltransferase 7
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB