anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Antibodies

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3B Kits (14) and DNMT3B Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT3B 1789 Q9UBC3
DNMT3B 444985  
DNMT3B 13436 O88509
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Top anti-DNMT3B Antibodies at

Showing 10 out of 135 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ChIP, CyTOF, FACS, ICC, IF, IHC, IHC (fro), IHC (p), IHC (wm), IP, SimWes, WB Western blot analysis for Dnmt3b using ABIN252478 at 2 ug/ml against 10 µg of cell lysates of 293 transfected with mouse Dnmt3a (lane 1) and Dnmt3b (lane 2). A protein band of approximate mol. wt. of 110 kDa is only detected in 293 cells transfected with mouse Dnmt3b cDNA. Western blot analysis of Dnmt3b in NIH 3T3 cell lysate using ABIN252478 at 4 ug/ml. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Dnmt3b Pab (ABIN387884) in T47-D cell lysate. Dnmt3b (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Western blot analysis using ABIN151734 to detect overexpressed DNMT-38 in HCT116 cells. Lane 1: 40 ug of nuclear extract from untransfected T24 cells. Lane 2-3: 40 ug of nuclear extracts transiently transfected to overexpress DNMT3B2 and DNMT3B3, respectively. Immunohistochemistry: Dnmt3b Antibody [ABIN151734] - Dnmt3b antibody was tested in mouse testis using DAB with hematoxylin counterstain. 0.1 mL Log in to see 7 to 9 Days
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-DNMT3B Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>OVCAR-3 cell lysate Sample Type: Lane 1:241 µg mouse mesenchymal stem cell lysate <br />Primary Antibody Dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 Color/Signal Descriptions: DNMT3B <br /> Gene Name: Anonymous <br /><br />Submitted by: 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ChIP, IHC, IHC (p), SimWes, WB Immunohistochemistry-Paraffin: DNMT3B Antibody [ABIN152675] - Analysis showing positive staining in the nucleus and cytoplasm of Mouse brain tissue (right) compared with a negative control in the absence of primary antibody (left). Western Blot: DNMT3B Antibody [ABIN152675] - Homogenized mouse brain cells. Image from verified customer review. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of DNMT3B staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of DNMT3B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, using DNMT3B Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using DNMT3B Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ChIP, WB DNMT3B mAb tested by Western blot. Detection of DNMT3B by Western blot. The analysis was performed using DNMT3B mAb at a 2 µg/ml dilution and whole-cell extracts from 293 cells that had been transfected with plasmid expressing either mouse DNMT3A (lane A) or DNMT3B (lane B). 100 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of U251 and mouse spleen cells, using DNMT3B antibody. 100 μL Log in to see 16 Days

DNMT3B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DNMT3B Antibodies

  1. Human Monoclonal DNMT3B Primary Antibody for ChIP, CyTOF - ABIN252478 : Santoro, Li, Grummt: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. in Nature genetics 2002 (PubMed)
    Show all 97 Pubmed References

  2. Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN151734 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003 (PubMed)
    Show all 16 Pubmed References

  3. Human Polyclonal DNMT3B Primary Antibody for IHC (p), WB - ABIN387884 : Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: Systems-level dynamic analyses of fate change in murine embryonic stem cells. in Nature 2009 (PubMed)
    Show all 13 Pubmed References

  4. Human Polyclonal DNMT3B Primary Antibody for ChIP, IHC - ABIN152675 : Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999 (PubMed)
    Show all 6 Pubmed References

  5. Human Polyclonal DNMT3B Primary Antibody for IF (p), IHC (p) - ABIN727623 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal DNMT3B Primary Antibody for ChIP, WB - ABIN2668954 : Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. in Molecular cancer research : MCR 2013 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN314552 : Fűri, Sipos, Spisák, Kiszner, Wichmann, Schöller, Tulassay, Műzes, Molnár: Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status. in TheScientificWorldJournal 2014 (PubMed)

  8. Human Monoclonal DNMT3B Primary Antibody for WB - ABIN2668953 : Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. in Nucleic acids research 2011 (PubMed)

  9. Mouse (Murine) Polyclonal DNMT3B Primary Antibody for WB - ABIN2668253 : Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013 (PubMed)

More Antibodies against DNMT3B Interaction Partners

Zebrafish DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. dnmt7 specifically methylates no tail gene in the genome

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.

Human DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Alternative splice variant of DNMT3B is associated with leukemia.

  2. these results provided a plausible link between the observed reduction of miR (show MLXIP Antibodies)-26a and MEG3 (show FAM129B Antibodies) in HCCs (show HCCS Antibodies). Together, the present study added miR (show MLXIP Antibodies)-26a/DNMT3B/MEG3 (show FAM129B Antibodies) axis to the complex mechanisms of HCC (show FAM126A Antibodies) development.

  3. Results show that DNMT1 (show DNMT1 Antibodies) mRNA levels were significantly higher in alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma tumors compared to normal skeletal muscle. Thse data indicate that altered expression of DNMT3B plays a key role in embryonal rhabdomyosarcoma development since its silencing is able to reverse cell cancer phenotype by rescuing myogenic program.

  4. The present study shows that DNMT3B rs2424913 promotor polymorphism represents a genetic risk factor that may play an important role in understanding the pathogenesis of chronic immune thrombocytopenia.

  5. LMP1-mediated NF-kappaB can up-regulate DNMT3b transcription, thereby leading to relatively higher methylation intensity at PTEN CpG islands, and ultimately silencing major tumor suppressor PTEN

  6. DNMT1 (show DNMT1 Antibodies), DNMT3A (show DNMT3A Antibodies), and DNMT3B were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (show DNMT1 Antibodies) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (show DNMT1 Antibodies) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (show DNMT1 Antibodies) A201G gene polymorphi

  7. report the first crystal structure of the DNMT3B PWWP domain-H3K36me3 complex.

  8. Results continue to establish ANG (show ANG Antibodies) as an oncoprotein and further reveal that ANG (show ANG Antibodies) contributes to oncogenesis by the activation of MMP2 (show MMP2 Antibodies) through modulation of DNMT3b functions.

  9. found association between DNMT3B rs2424913 in T allele carriers with Parkinson's disease

  10. H19 (show NCKAP1 Antibodies) might function as ceRNA (competing endogenous RNA) for miR (show MLXIP Antibodies)-29b-3p and relieve the suppression for DNMT3B, which led to EMT (show ITK Antibodies) and metastasis of bladder cancer (BC). Our findings highlight a novel mechanism of H19 (show NCKAP1 Antibodies) in progression of BC and provide H19 (show NCKAP1 Antibodies)/miR (show MLXIP Antibodies)-29b-3p/DNMT3B axis as a promising therapeutic target for BC.

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. The epiblast expressed epithelial markers, MUC1 (show MUC1 Antibodies) and E-CADHERIN (show CDH1 Antibodies), and the pluripotency markers, DNMT3B and CRIPTO (show TDGF1 Antibodies).

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.

  2. The expression levels of DNMT3a (show DNMT3A Antibodies) and DNMT3b were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Altogether, the authors demonstrate that Dnmt3a (show DNMT3A Antibodies) and Dnmt3b protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (show PPARG Antibodies).

  2. a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.

  3. Together, this study described the regulation of Chk2 (show CHEK2 Antibodies) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (show CHEK2 Antibodies) during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  4. in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation

  5. three DNA methyltransferases, Dnmt1 (show DNMT1 Antibodies), Dnmt3a (show DNMT3A Antibodies), and Dnmt3b, have been identified. Dnmt3a (show DNMT3A Antibodies) and Dnmt3b are responsible for establishing DNA methylation (show HELLS Antibodies) patterns produced through their de novo-type DNA methylation (show HELLS Antibodies) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (show TRDMT1 Antibodies)), which is a member of the Dnmt3 family but does not possess DNA methylation (show HELLS Antibodies)

  6. While lens epithelial cell survival requires DNMT1 (show DNMT1 Antibodies), morphologically normal lenses develop in the absence of both DNMT3A (show DNMT3A Antibodies) and DNMT3B.

  7. Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.

  8. a miR (show MLXIP Antibodies)-125b-DNMT3b-p53 (show TP53 Antibodies) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.

  9. miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (show DNMT1 Antibodies), DNMT3b and SET1A (show SETD1A Antibodies) expression in hepatic stellate cells.

  10. Loss of DNMT3B results in hypomethylation of the miR (show MLXIP Antibodies)-196b promoter and increased miR (show MLXIP Antibodies)-196b expression, which directly targets the mTORC2 (show CRTC2 Antibodies) component Rictor (show RICTOR Antibodies).

DNMT3B Antigen Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Gene names and symbols associated with DNMT3B

  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 (dnmt3bb.1) antibody
  • DNA methyltransferase 3 beta (DNMT3B) antibody
  • microtubule associated protein RP/EB family member 1 (MAPRE1) antibody
  • DNA methyltransferase 3 beta (dnmt3b) antibody
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a (dnmt3ba) antibody
  • DNA methyltransferase 3 beta (Dnmt3b) antibody
  • DNA methyltransferase 3B (Dnmt3b) antibody
  • cb91 antibody
  • cb633 antibody
  • DNMT3B antibody
  • dnmt3bl antibody
  • dnmt7 antibody
  • ICF antibody
  • ICF1 antibody
  • LOC100218113 antibody
  • M.HsaIIIB antibody
  • MmuIIIB antibody
  • sb:cb91 antibody
  • wu:fb16h07 antibody

Protein level used designations for DNMT3B

DNA (cytosine-5)-methyltransferase 3B , DNA (cytosine-5-)-methyltransferase 3 beta , DNA cytosine-5 methyltransferase 3 beta , DNA (cytosine-5)-methyltransferase 3B-like , DNA methyl transferase beta , DNA methyltransferase 3B , DNA MTase HsaIIIB , DNA methyltransferase HsaIIIB , DNA (cytosine-5-)-methyltransferase 3 beta, like , DNA (cytosine-5-)-methyltransferase 7 , fb16h07 , DNA MTase MmuIIIB , DNA methyltransferase MmuIIIB

317744 Danio rerio
458174 Pan troglodytes
711553 Macaca mulatta
100053900 Equus caballus
100218113 Taeniopygia guttata
100412936 Callithrix jacchus
100459992 Pongo abelii
100466728 Ailuropoda melanoleuca
100500777 Ovis aries
100598378 Nomascus leucogenys
100528060 Anolis carolinensis
1789 Homo sapiens
321084 Danio rerio
419287 Gallus gallus
100302109 Sus scrofa
353354 Bos taurus
444985 Rattus norvegicus
13436 Mus musculus
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