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anti-DNA Cross-Link Repair 1A (DCLRE1A) Antibodies

DCLRE1A encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCLRE1A 9937 Q6PJP8
Anti-Rat DCLRE1A DCLRE1A 292127  
Anti-Mouse DCLRE1A DCLRE1A 55947  
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Top anti-DNA Cross-Link Repair 1A Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
$429.87
Details
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
$429.87
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with DCLRE1A antibody ABIN298128 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Human Heart (formalin-fixed, paraffin-embedded) stained with DCLRE1A antibody ABIN291867 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using DCLRE1A antibody (ABIN6292016) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 50 μL 11 to 13 Days
$305.01
Details
Human Rabbit Un-conjugated IF, IHC (p) Immunofluorescent staining of human cell line A-431 with DCLRE1A polyclonal antibody at 1-4 ug/mL dilution shows positivity in nucleus and nucleoli. Immunohistochemical staining of human placenta with DCLRE1A polyclonal antibody shows strong nuclear positivity in trophoblastic cells. 100 μL 11 to 12 Days
$577.33
Details
Human Goat APC ELISA   100 μL 16 Days
$653.71
Details
Human Goat APC ELISA   100 μL 16 Days
$653.71
Details
Human Goat Alkaline Phosphatase (AP) ELISA   100 μL 16 Days
$653.71
Details
Human Goat Biotin ELISA   100 μL 16 Days
$653.71
Details

Top referenced anti-DNA Cross-Link Repair 1A Antibodies

  1. Human Polyclonal DCLRE1A Primary Antibody for ELISA - ABIN547575 : Akhter, Richie, Deng, Brey, Zhang, Patrick, Behringer, Legerski: Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. in Molecular and cellular biology 2004 (PubMed)

  2. Human Polyclonal DCLRE1A Primary Antibody for ELISA - ABIN547285 : Richie, Peterson, Lu, Hittelman, Carpenter, Legerski: hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. in Molecular and cellular biology 2002 (PubMed)

More Antibodies against DNA Cross-Link Repair 1A Interaction Partners

Human DNA Cross-Link Repair 1A (DCLRE1A) interaction partners

  1. Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink.

  2. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.

  3. Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B.

  4. differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles

  5. collaboration between hSNM1A and XPF-ERCC1 is necessary to initiate interstrand cross-link repair in replicating human cells

  6. RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger

  7. Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage.

  8. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation

  9. The SNM1 enzyme utilizes either DNA or RNA substrates, requires a 5'-phosphate moiety, shows very little activity on double-strand substrates, and functions at a size consistent with a monomer.

  10. Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.

  11. hSNM1 appears to represent a second pathway for genome stability

  12. These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint.

Mouse (Murine) DNA Cross-Link Repair 1A (DCLRE1A) interaction partners

  1. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation

  2. Snm1 is a tumor suppressor in mice that in addition has a role in immunity

DNA Cross-Link Repair 1A (DCLRE1A) Antigen Profile

Protein Summary

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with DCLRE1A

  • DNA cross-link repair 1A (DCLRE1A) antibody
  • DNA cross-link repair 1A (Dclre1a) antibody
  • DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) (dclre1a) antibody
  • 2810043H12Rik antibody
  • AU022226 antibody
  • fc49f05 antibody
  • im:7145629 antibody
  • mKIAA0086 antibody
  • Pso2 antibody
  • Smn1a antibody
  • Snm1 antibody
  • Snm1-like antibody
  • SNM1A antibody
  • wu:fc49f05 antibody
  • zgc:109999 antibody

Protein level used designations for DCLRE1A

DNA cross-link repair 1A protein , DNA-crosslink repair gene SNM1 , SNM1 homolog A , DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) , chSNM1A , DNA cross-link repair 1A , DNA cross-link repair 1A protein-like , LOW QUALITY PROTEIN: DNA cross-link repair 1A protein

GENE ID SPECIES
9937 Homo sapiens
292127 Rattus norvegicus
423902 Gallus gallus
477824 Canis lupus familiaris
504377 Bos taurus
100359072 Oryctolagus cuniculus
100467042 Ailuropoda melanoleuca
100593712 Nomascus leucogenys
55947 Mus musculus
100723290 Cavia porcellus
324964 Danio rerio
100156734 Sus scrofa
100068217 Equus caballus
Selected quality suppliers for anti-DNA Cross-Link Repair 1A (DCLRE1A) Antibodies
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