anti-DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Antibodies

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. Additionally we are shipping DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCLRE1B 64858 Q9H816
DCLRE1B 310745 Q4KLY6
DCLRE1B 140917 Q8C7W7
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Top anti-DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of DCLRE1B expression in HOS (A) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC205744 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DCLRE1B antibody (ABIN2454181), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCLRE1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DCLRE1B. 0.1 mL 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of DCLRE1B using COLO205 whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the detected DCLRE1B protein (arrow). DCLRE1B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of THP-1 cells, using DCLRE1B antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of THP-1 cells, using DCLRE1B antibody (ABIN5995432) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

More Antibodies against DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Interaction Partners

Human DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) interaction partners

  1. Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B.

  2. The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.

  3. the N-terminal region of Snm1B forms a complex containing PSF2 and Mus81, while the C-terminal region is important for PSF2-mediated chromatin association.

  4. The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.

  5. differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles

  6. SNM1B functions epistatically to the central Fanconi anemia factor, FANCD2, in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks

  7. TRF2, which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1, TOP2alpha, and TOP2beta at telomeres.

  8. siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair

  9. the C terminus of Snm1B was shown to interact with the TRF homology domain of TRF2 indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2

  10. SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease activity and functions together with TRF2 to protect telomeres from damage and fusion.

  11. SNM1B (Apollo) is an Artemis-like nuclease that is required for the protection of telomeres during or after their replication. [Apollo]

  12. observations suggest an important role for hSNM1B in the response to ionizing radiation damage, a role that may be, in part, upstream of the central player in maintenance of genome integrity, ATM

  13. Snm1B interacts with the Mre11-Rad50-Nbs1 (MRN) complex and with FancD2 further substantiating its role as a checkpoint/DNA repair protein.

  14. The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2

  15. Results suggest that SNM1B/Apollo and Astrin function together to enforce the prophase checkpoint in response to spindle stress.

  16. DCLRE1B protein binds to a C-terminal fragment of HSP72 Heat-Shock Proteins, known to contain the substrate binding domain.

Mouse (Murine) DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) interaction partners

  1. Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.

  2. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development

  3. TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.

  4. Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.

DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Antigen Profile

Protein Summary

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000

Gene names and symbols associated with DCLRE1B

  • DNA cross-link repair 1B (DCLRE1B) antibody
  • DNA cross-link repair 1B (Dclre1b) antibody
  • DNA cross-link repair 1B (dclre1b) antibody
  • AI452214 antibody
  • Apollo antibody
  • im:6894074 antibody
  • mSNM1B antibody
  • SNM1B antibody
  • SNMIB antibody
  • zgc:154089 antibody

Protein level used designations for DCLRE1B

5' exonuclease Apollo , DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) , PSO2 homolog , SNM1 homolog B , DNA cross-link repair 1B protein

GENE ID SPECIES
64858 Homo sapiens
428269 Gallus gallus
310745 Rattus norvegicus
768137 Danio rerio
140917 Mus musculus
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