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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.
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physical cooperation between BTAF1 and NC2alpha in TBP (show TBP ELISA Kits) regulation
The global distribution of DRAP1 on promoters was determined.
provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP (show TBP ELISA Kits)-DNA complex that allow it to escape and return to TATA-binding mode
heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
, DR1-associated protein 1 (negative cofactor 2 alpha)
, dr1-associated protein 1
, negative co-factor 2-alpha
, negative cofactor 2 alpha