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anti-Decapping Enzyme, Scavenger (DCPS) Antibodies

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Additionally we are shipping Decapping Enzyme, Scavenger Proteins (9) and Decapping Enzyme, Scavenger Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCPS 28960 Q96C86
DCPS 69305 Q9DAR7
DCPS 266605 Q8K4F7
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Top anti-Decapping Enzyme, Scavenger Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Mouse Un-conjugated ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to DCPS on HeLa cell (antibody concentration 10 µg/mL). DCPS monoclonal antibody (M02), clone 1G4 Western Blot analysis of DCPS expression in HeLa. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated ELISA, IHC, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (62.81 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB DCPS Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DCPS antibody detected the DCPS protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of HT-29 cells, using DCPS antibody. Western blot analysis of extracts of HT-29 cells, using DCPS antibody (ABIN4903455) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s. 100 μL Log in to see 16 Days
$366.77
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB DCPS monoclonal antibody (M03), clone 3E5 Western Blot analysis of DCPS expression in HeLa . Immunoperoxidase of monoclonal antibody to DCPS on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-Decapping Enzyme, Scavenger Antibodies

  1. Human Polyclonal DCPS Primary Antibody for ICC, IF - ABIN4304527 : Ng, Shboul, Taverniti, Bonnard, Lee, Eskin, Nelson, Al-Raqad, Altawalbeh, Séraphin, Reversade: Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects. in Human molecular genetics 2015 (PubMed)

More Antibodies against Decapping Enzyme, Scavenger Interaction Partners

Human Decapping Enzyme, Scavenger (DCPS) interaction partners

  1. Data show that decapping scavenger enzyme DcpS (DcpS) is a nucleocytoplasmic shuttling protein that activates microRNA (miRNA) degradation.

  2. In DcpS, conformational change is dominated by an anti-symmetric cooperative motion, causing one active site to close as the other opens; however a symmetric motion is also significant.

  3. In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentration.

  4. DCPS and more generally RNA catabolism, are critical for neurological development, normal cognition and organismal homeostasis in humans.

  5. data demonstrate that DcpS in conjunction with Xrn1 has the potential to regulate RNA stability in a transcript-selective manner in mammalian cells

  6. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

  7. m7GDP breakdown by DcpS should prevent misincorporation of methylated nucleotides in nucleic acids and could generate a unique indicator allowing the cell to monitor mRNA decay.

  8. Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis.

  9. crystal structures of DcpS in ligand-free form and in a complex with m7GDP

  10. Furthermore, we show that a novel human histidine triad protein DCS-1, which is expressed together with NR1 in many tissues, can significantly reduce menadione-induced cytotoxicity in these cells

  11. These studies demonstrate that the significance of DcpS extends beyond its well-characterized role in mRNA decay and involves a broader range of functions in RNA processing including nuclear pre-mRNA splicing.

  12. biochemical analysis of the dynamic and mutually exclusive cap hydrolysis activity of the two cap binding sites of DcpS

  13. Data established that DcpS, a key enzyme in mRNA decay, is a new target of DeltaLf transcriptional activity.

Mouse (Murine) Decapping Enzyme, Scavenger (DCPS) interaction partners

  1. Amino acid sequence and xray crystallograpy structure given

Decapping Enzyme, Scavenger (DCPS) Antigen Profile

Protein Summary

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.

Gene names and symbols associated with DCPS

  • decapping enzyme, scavenger (DCPS) antibody
  • decapping enzyme, scavenger (dcps) antibody
  • decapping enzyme, scavenger (Dcps) antibody
  • 1700001E16Rik antibody
  • AA408441 antibody
  • DCPS antibody
  • DCS1 antibody
  • Hint-5 antibody
  • HINT5 antibody
  • HSL1 antibody

Protein level used designations for DCPS

decapping enzyme, scavenger , DCS-1 , decapping scavenger enzyme , heat shock-like protein 1 , hint-related 7meGMP-directed hydrolase , histidine triad nucleotide-binding protein 5 , histidine triad protein member 5 , homolog of C. elegans 7meGMP-directed hydrolase dcs-1 , m7GpppX diphosphatase , mRNA decapping enzyme , scavenger mRNA-decapping enzyme DcpS , HINT-5

GENE ID SPECIES
419716 Gallus gallus
609536 Canis lupus familiaris
100216298 Xenopus (Silurana) tropicalis
28960 Homo sapiens
69305 Mus musculus
266605 Rattus norvegicus
282640 Bos taurus
396689 Sus scrofa
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