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Plasma alpha-Defs 1-3 concentrations correlate with the degree of inflammation and appear to be specific biomarkers of ileal-Crohn's disease at diagnosis. Ileal alpha-Def 5 expression is down-regulated permanently by methylation.
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The binding mechanisms of HD5 on lipopolysaccharide in comparison to a bare DMPC lipid membrane was studied using molecular dynamics (MD) simulations.
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Bifidobacterium infantis NLS super strain decreases Paneth cell counts and expression of alpha-defensin-5 in celiac disease.
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Human alpha-Defensin-5 is a potential candidate biomarker to molecularly differentiate Crohn's colitis from ulcerative colitis, to our knowledge. These data give us both a potential diagnostic marker in Human alpha-Defensin-5 and insight to develop future mechanistic studies to better understand crypt biology in Crohn's colitis.
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Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 and HBD-3.
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These data support capsid stabilization and redirection to the lysosome during infection as a general antiviral mechanism of alpha-defensins against nonenveloped viruses.
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Human adenovirus 3 produces large amounts of penton-dodecahedra (PtDd), virus-like particles, during replication, which also function in blocking of HD5.
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no biologic differences between wild-type HD5 and its variants were observed on HD5 antibacterial activity against Escherichia coli
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a moderately active linear peptide derived from the alpha-defensin HD5 can be engineered to enhance antimicrobial activity almost comparable to the native peptide.
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The study used ion mobility coupled to mass spectrometry to track the structural changes in HD-5 upon disulfide bond reduction.
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The study reports the screening of human defensin 5 against the Keio Collection of E. coli strains and shows how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.
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Authors show that although NOD2 by itself can slightly up-regulate expression of HD5 and HD6, it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK pathway.
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HD5ox, at least in part, exerts its antibacterial activity against E. coli and other Gram-negative microbes in the cytoplasm.
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These data support a model in which HD5 prevents furin from accessing human papillomavirus 16 L2 by occluding the furin cleavage site via direct binding to the viral capsid.
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Enteric alpha-defensin HD5 and beta-defensin hBD2 shared similar toxin-unfolding effects with HNP1, albeit to different degrees.
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our results highlight the potential contribution of altered alpha-defensin HD-5 expression in the formation of a viral/tumour-permissive environment in high-risk HPV infection and progression to cancer of the uterine cervix
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DEFA5 displays antimicrobial activity against E. coli, E. aerogenes, B. cereus, and S. aureus.
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Data indicate that cellular effects of defensin 5 involve interactions with the extra-cellular domain of tumor necrosis Factor 1.
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Anti-HIV activity of human defensin 5 in primary CD4+ T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity.
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This study considers the redox properties of HD-5 and reports that the reduced form, HD-5 red, is a zinc-ion chelator.
