anti-Defensin, beta 1 (DEFB1) Antibodies

Human Defensin, beta 1 (DEFB1) interaction partners

1. Results provide evidence that DEFB1 is associated with vitiligo. Its polymorphism may modulate vitiligo risk whereas HBD-1 blood levels might be related to its pathogenesis.

2. our results suggest beta-defensin 1 plays an important role in protecting HCV progression and liver cancer development.

3. Damaging nonsense variants of African ancestry in the DEFB1 and MBL2 genes that encode anti-microbial proteins that presumably defend the fetal membranes from infectious agents confer risk of preterm premature rupture of membranes and preterm birth in African Americans.

4. novel DEFB1/hBD-1 properties and biomarker features.

5. These results extend the immunoregulatory effects of hBD-1 and provide a potential mechanism for the protective role of hBD-1 in early infants.

6. C allele of -44 C/G polymorphism, as well as haplotype AC are associated with the presence of T2DM in the Mexican population.

7. The single nucleotide polymorphism in DEFB1 gene is associated with the risk of acute respiratory distress syndrome.

8. In this Brazilian population, genetic variations of DEFB1 gene (SNP-20: G allele and GA and GG genotypes) and the DEFB1 5'UTR haplotypes (GCG and ACG) may be associated with a susceptibility to chronic periodontitis in DM2 individuals as well as CP individuals without diabetes mellitus type 2.

9. The allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Brazilian Manaus group. In the Ribeirao Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience.

10. These studies identified SNPs that were cis-eQTLs for DEFB1 and AHR and, which were associated with variation in plasma KYN concentrations that were related to severity of major depressive disordersymptoms.

11. a considerable connection of DEFB1 and TCF7L2 gene polymorphisms with nephrolithiasis

12. identification of critical promoter regions of DEFB1 that are epigenetically influenced by lactobacilli in vaginal keratinocytes

13. Endometrial tissues and epithelial cells constitutively secreted both BD-1 and -2 mostly at the apical compartment. Both genistein and daidzein induced BDs secretion which reached a peak at 5-15 min. The apical secretion of BDs was coincidence with increased Cl- secretion induced by genistein.

14. The polymorphisms in DEFB1 were not associated with hBD salivary level and caries experience (p > 0.05) in children.

15. These findings suggest a role for hBD-1 in psoriasis pathogenesis

16. Significant associations were found between periodontitis and g. -20G> A (rs11362) and g. -44C> G (rs1800972) SNPs in DEFB1 gene as well as p.Ala29Thr (rs1126477) and p.Lys47Arg (rs1126478) SNPs in LTF gene.

17. hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.

18. findings lead us to hypothesize an involvement of hBD-1 mediated innate immunity in the modulation of the susceptibility towards adeno-tonsillar hypertrophy development.

19. Two DEFB1 SNPs were significantly associated with the DMFT(decayed, missing, filled teeth) index.

20. Multivariate logistic regression analysis showed that hBD-1 basal cell loss (>/=20% of prostatic glands in total cores) is an independent factor for predicting prostatic adenocarcinoma (odds ratio: 4.739, confidence interval: 1.093-20.554, p = 0.038). hBD-1 loss of basal cells is a useful indicator to identify extremely high-risk patients with initially negative biopsy.

Mouse (Murine) Defensin, beta 1 (DEFB1) interaction partners

1. Fenofibrate and gemfibrozil inhibit LPS-induced inflammatory activation of macrophages via PPARalpha/beta-defensin 1/TLR4 pathway.

2. these studies demonstrate a role for the murine beta-defensin 1 peptide in early control of Candida infection in a murine model of mucosal candidiasis

3. Akt1 is involved in the regulation of defensin expression and the innate immune response important for bacterial clearance

4. Histopathology showed a greater inflammatory influx in the lungs of mBD-1((-/-)) mice at Day 3 postinfection compared with WT C57BL/6 mice

5. The decreased production of antimicrobial peptides by burn-site epidermal keratinocytes influenced by Gr-1(+)CD11b(+) cells was shown to be restored by glycyrrhizin.

6. elimination of mBD-1 results in a defect in the ability of the host to clear H. influenzae from the lung, which is most consistent with this peptide functioning as an antibiotic at the airway surface.

7. Murine beta-defensins-1 and -4 were present in newborn skin.

8. The expression of BD1 was significantly elevated in the lungs of cigarette smoke-exposed mice compared with air-exposed mice.

9. Although both murine beta-defensin (mBD)-1 and mBD2 are constitutively expressed in normal BALB/c and C57BL/6 corneas, mBD-1 is not required for host resistance against Pseudomonas aeruginosa-induced corneal infection.

Pig (Porcine) Defensin, beta 1 (DEFB1) interaction partners

1. pBD1 showed low hemolytic activity and high thermal stability. These properties are relevant for the biotechnological applications of the peptide.

2. Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.

3. Presence of beta-defensin 1 in the upper respiratory tract is associated with resistance against respiratory infection with Bordetella pertussis in older piglets