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DHPS encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A.
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the use of N1-Guanyl (show GUCA2A Proteins)-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis.
Whereas, dhps mutation study revealed that triple mutant haplotype AGEAA (S436A+A437G+K540E) associated with Sulphadoxine resistance was found among 26% of P. falciparum field isolates.
eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample
DHPS and WDR83 (show wdr83 Proteins) were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation.
A novel series of cell movements that orient the polarity of Lrp12 (show LRP12 Proteins)/Mig13a-expressing neurons and their axons just prior to cortical plate assembly do not occur in reeler (show RELN Proteins) mutant mice.
deoxyhypusine synthase has a role in generating spermidine or homospermidine
deoxyhypusine synthase and its phosphorylation modification may have other independent cellular functions because of versatile roles of deoxyhypusine synthase
crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex
Dhps-437 and dhps-540 are strongly associated with SP treatment failure and should be evaluated further as a method for surveillance of SP-based therapy in DRC (show FECH Proteins).
Deletion of hypusine modification enzymes ( deoxyhypusine synthase and deoxyhypusine hydroxylase (show DOHH Proteins) )exerts strong phenotypes. eIF-5A2 (show EIF5A2 Proteins)-deleted animals are viable and fertile.
The results suggest a previously unrecognized role for deoxyhypusine synthase in promoting T cell proliferation and differentiation via regulation of CD25 (show IL2RA Proteins).
knockout of either the eIF5A (show EIF5A Proteins)-1 gene (Eif5a (show EIF5A Proteins)) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A (show EIF5A Proteins)-1 and deoxyhypusine synthase in mammalian development
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
DHS is required for the ongoing production of proteins, particularly CHOP (show DDIT3 Proteins), in response to ER stress in the beta cell.
The the deduced bovine deoxyhypusine synthase protein showed a 93% identity to the human protein.
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, Deoxyhypusine synthase
, migration-inducing gene 13