anti-Deoxyribonuclease I-Like 3 (DNASE1L3) Antibodies

Human Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

1. The authors found a significant reduction in serum DNase1l3 level in dermatomyositis/polymyositis and systemic lupus erythematosus, which may associate with clinic features and disease activity.

2. Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.

3. Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470.

4. Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases.

5. DNASE1L3 mutations occur in hypocomplementemic urticarial vasculitis syndrome.

6. These results suggest a cooperative activity between CAD and DNAS1L3 to accomplish internucleosomal DNA fragmentation .

7. We identified a rare autosomal recessive form of systemic lupus erythematosus, in which autozygome analysis revealed a null mutation in the DNASE1L3 gene

8. investigates the distribution of DNASE1L3 gene SNPs in exons of the gene in eight Asian, three African, and three Caucasian populations worldwide using newly devised genotyping methods.

9. The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells.

10. Identification of two functional nuclear localization signals in DNase gamma that have a role in apoptotic DNA fragmentation.

11. DNase gamma is involved in the generation of resected double-strand DNA breaks associated with somatic hypermutation

12. DNAS1L3 plays an active role in lymphoma cell sensitization to VP-16 and its deficiency may constitute a novel mechanism of drug resistance in these cells

13. A Caucasian-specific allele in SNP R206C produces an inactive form of DNase Il3.

14. Results distinguish DNase gamma-dependent and CAD/DFF40-dependent DNA fragmentations, and show that even if DNA fragmentation is initiated by CAD/DFF40, DNase gamma is required for the more complete digestion of the genomic DNA in dying cells.

Xenopus laevis Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

1. Cloning and apoptotic DNase activity of Xenopus laevis DNase gamma

Mouse (Murine) Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

1. These results support a distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity.

2. DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps.

3. Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response.

4. DNase gamma, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis.

5. A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported.

6. These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase activation.

7. serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells.