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The protein encoded by DGKA belongs to the eukaryotic diacylglycerol kinase family. Additionally we are shipping DGKA Antibodies (112) and DGKA Proteins (12) and many more products for this protein.
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An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed
Decreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1 (show EGR1 ELISA Kits)) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.
These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.
DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1
High diacylglycerol kinase alpha expression is associated with glioblastoma.
DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK (show MAPK1 ELISA Kits) pathway.
DGK-alpha was more highly expressed in CD8 (show CD8A ELISA Kits)-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes.
Antigen-specific CD8 (show CD8A ELISA Kits)-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8 (show CD8A ELISA Kits)+ T cells exhibit impaired expansion.
SAP (show APCS ELISA Kits)-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation
Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes.
Our studies demonstrate that PKD1 (show PKD1 ELISA Kits)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.
Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
Ovalbumin (show OVA ELISA Kits)-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation.
Data indicate that combined deletion of dgkzeta and dgkalpha markedly enhances T-cell responses.
The data strongly supported a role for FoxO (show FOXO3 ELISA Kits) proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses.
results suggest that the globular form of adiponectin-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha
DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR (show FRAP1 ELISA Kits) activation by inhibiting the Ras-Mek1 (show MAP2K1 ELISA Kits)/2-Erk (show EPHB2 ELISA Kits)/12 pathway
A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo.
regulated by pi 3 (show PI3 ELISA Kits)-kinase activation products
Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells.
the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
80 kDa diacylglycerol kinase
, DAG kinase alpha
, diacylglycerol kinase alpha
, diglyceride kinase alpha
, diacylglycerol kinase alpha Flt2-Pr2
, truncated diacylglycerol kinase alpha Flt1-Pr1
, diacylglycerol kinase, alpha 80kDa
, diacylglycerol kinase alpha-like