Diacylglycerol Kinase, alpha 80kDa (DGKA) ELISA Kits

Human Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

1. This novel study demonstrates efficient ablation of diacylglycerol kinase in human CAR-T cells that leads to improved antitumor immunity and may have significant impact in human cancer immunotherapy

2. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review)

3. DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression.

4. LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis

5. An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed

6. Decreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.

7. Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions.

8. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.

9. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1

10. High diacylglycerol kinase alpha expression is associated with glioblastoma.

11. DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK pathway.

12. DGK-alpha was more highly expressed in CD8-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes.

13. Antigen-specific CD8-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion.

14. SAP-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation

15. Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes.

16. findings further suggest that DGL-alpha and -beta may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways

17. Defects in both polymorphonuclear neutrophil (PMN) transendothelial migration and PMN diacylglycerol kinase alpha signaling are implicated as disordered functions in subjects with localized aggressive periodontitis.

18. PPARgamma agonists upregulate DGKalpha production.This suppresses the diacylglycerol/protein-kinase-C signaling pathway.

19. DGKalpha is crucial for the control of cell activation and also for the regulation of the secretion of lethal exosomes, which in turn controls cell death.

20. ALK-mediated alphaDGK activation is dependent on p60src tyrosine kinase, with which alphaDGK forms a complex; alphaDGK activation is involved in the control of ALK-mediated mitogenic properties.

Mouse (Murine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

1. results suggest DGKalpha aids in modulating the early immune response of adipose tissue following an acute exposure to high-fat diet, possibly through modulation of acute T-cell action

2. this study shows that diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice

3. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review)

4. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.

5. Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

6. It plays a role in pathogenesis of various disorders in the central nervous system.

7. Ovalbumin-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation.

8. Data indicate that combined deletion of dgkzeta and dgkalpha markedly enhances T-cell responses.

9. The data strongly supported a role for FoxO proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses.

10. results suggest that the globular form of adiponectin-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha

11. DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR activation by inhibiting the Ras-Mek1/2-Erk/12 pathway

12. A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo.

13. regulated by pi 3-kinase activation products

14. Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells.

15. DGKs not only terminate diacylglycerol signaling but also initiate PA signaling in thymocytes to promote positive selection

16. Diacylglycerol kinase alpha deficiency causes enhanced T cell activation and confers resistance to anergy induction in vitro and in vivo.

Pig (Porcine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

1. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl