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DAGLA encodes a diacylglycerol lipase.
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phenotypes associated with rare CNR1 (show CNR1 Proteins) variants are reminiscent of those implicated in the theory of clinical endocannabinoid deficiency syndrome. The severe phenotypes associated with rare DAGLA variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development
In subcutaneous adipose tissue, DAGL-a mRNA was upregulated and fatty acid amide hydrolase (FAAH (show FAAH Proteins)) and monoacylglycerol lipase (MAGL (show MGLL Proteins)) mRNAs were down-regulated in obese subjects, but the diets had no influence.
PLC (show HSPG2 Proteins)-beta1 and DAGL-alpha are detected in discrete brain regions, with a marked predominance of pyramidal morphologies of positive cortical cells.[review]
DAGLalpha mRNA expression is lowest in early life and adulthood, peaking between school age and young adulthood.
This gene was functionally characterized as a diacylglycerol-lipase (show LIPG Proteins) (DAGL), specifically referred to as DAGL alpha. This enzyme may play a role in the biosynthesis of the endocannbinoid 2-arachidonoylglycerol (2-AG).
Results demonstrate that mice with a deletion of the DAGL-alpha enzyme show a phenotype of increased emotional or stress-related behaviors. This is characterized by a reduced exploration of the central area of the open field, a maternal neglect behavior, a fear extinction deficit, increased behavioral despair, increased anxiety-related behaviors in the light/dark box, and reduced hippocampal neurogenesis
Authors demonstrated that phospholipase D and diacylglycerol lipase (show LIPG Proteins) were required for providing arachidonic acid for prostaglandin E(2) biosynthesis.
In corpus striatum diacylglycerol lipase-alpha activity is regulated by calcium/calmodulin dependent protein kinase (CaMK-II).
DAGLalpha is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis.
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.
diacylglycerol lipase, alpha
, neural stem cell-derived dendrite regulator
, sn1-specific diacylglycerol lipase alpha-like
, sn1-specific diacylglycerol lipase alpha