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DPYSL5 encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Additionally we are shipping Dihydropyrimidinase-Like 5 Kits (15) and Dihydropyrimidinase-Like 5 Proteins (8) and many more products for this protein.
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Study describes the relevance of DRP5 during osteosarcoma development. DRP5 was upregulated in osteosarcoma specimens and cell lines and shown to function via the downstream MMPs. Inhibition of DRP5 suppressed the growth of cancer cells in vitro and in vivo, and high expression levels of DRP5 were associated with poor prognosis in osteosarcoma patients.
Our findings suggest that CRMP5 serves as a major mediator of Notch (show NOTCH1 Antibodies) signaling and Akt (show AKT1 Antibodies) activation by controlling the degradation of the Notch (show NOTCH1 Antibodies) receptor, with implications for defining a biomarker signature in glioblastoma
present study suggested that CRAM (show CCRL2 Antibodies) could be a clinical prognostic marker for patients with cervical cancer
study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function.
identified residues that are crucial for determining the preference for hetero-oligomer or homo-oligomer formation. In spite of being the CRMP family member most closely related to dihydropyrimidinase (show DPYS Antibodies), CRMP-5 does not have amidohydrolase activity.
New CRMP5 isoform present in the nucleus is associated with Glioma.
CRMP-5-IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells.
CRMP-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk.
We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of paraneoplastic optic neuropathy secondary to lung cancer marked by an extremely high titer of CRMP-5 antibody.
findings point at CRMP5 as a novel marker for distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers.
CRMP5-deficient mice show abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons.
These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity.
Data show that CRMP5 is involved in the development, maintenance and synaptic plasticity of Purkinje cells.
The CRMP5 binding to tubulin (show TUBB Antibodies) modulates CRMP2 (show DPYSL2 Antibodies) regulation of neurite outgrowth and neuronal polarity during brain development.
CRAM regulates filopodial dynamics and growth cone development, thereby restricting the response of growth cone to repulsive guidance cues
In the olfactory bulb, CRMP1 (show CRMP1 Antibodies), CRMP2 (show DPYSL2 Antibodies) and CRMP5 are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons.
Our results are therefore consistent with a role for CRMP5 in neuronal process extension.We conclude that expression of CRMP5 is consistent with a dynamic implicit role in forebrain development.
Hypoxia-ischemia (HI)induces dephosphorylation of CRMPs (CRMP1 (show CRMP1 Antibodies), 2, and 5) in neonatal brain. Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders.
This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, dihydropyrimidinase-related protein 5
, Dihydropyrimidinase-related protein 5
, collapsin response mediator protein-5
, dihydropyrimidinase-related protein 5-like
, CRMP3-associated molecule
, UNC33-like phosphoprotein 6
, collapsin response mediator protein 5