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p59 isoform inhibits growth in prostatic epithelial cells [RGD, Feb 2006]..
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Human Monoclonal DAB2 Primary Antibody for IF, IP - ABIN967989
Hocevar, Smine, Xu, Howe: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. in The EMBO journal 2001
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Human Monoclonal DAB2 Primary Antibody for IF, IP - ABIN967990
Mishra, Keyel, Hawryluk, Agostinelli, Watkins, Traub: Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. in The EMBO journal 2002
Show all 4 Pubmed References
The results suggest that Dab2 is required for the excessive calorie-induced differentiation of an adipocyte progenitor cell population that is present in juvenile but depleted in mature animals. The finding provides evidence for a limited pre-adipocyte population in juvenile mammals and the requirement of Dab2 in the regulation of Ras/MAPK (show MAPK1 Antibodies) signal in the commitment of the precursor cells to adipose tissues.
The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
The combination of Arh (show LDLRAP1 Antibodies) and Dab2 is responsible for the majority of adaptor function in LDLR (show LDLR Antibodies) endocytosis and LDLR (show LDLR Antibodies)-mediated cholesterol homeostasis.
cathepsin B (CTSB (show CTSB Antibodies)) inhibition or expression of a CTSB (show CTSB Antibodies)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (show TGFB1 Antibodies)-treated cells from autophagy to apoptosis
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
Dab2 expression is induced by hormones
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 Antibodies) in mice.
Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) are involved in albumin (show ALB Antibodies) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 Antibodies) induces albumin (show ALB Antibodies) endocytosis in proximal tubule epithelial cells.
p59 isoform inhibits growth in prostatic epithelial cells
, DOC-2 p82 isoform
, disabled homolog 2
, disabled homolog 2 mitogen-responsive phosphoprotein
, mitogen-responsive phosphoprotein