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Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity).. Additionally we are shipping and many more products for this protein.
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Results suggest that drg11 expression in the developing zebrafish is, like its mammalian homologous gene, predominantly localised to neurons in sensory processing areas of the embryonic nervous system and is both spatially and temporally regulated.
Study shows that Casz1 lies downstream of Prrxl1 in the differentiation pathway of a large subset of dorsal late-born excitatory neurons and provides a framework for further studies of Casz1 in assembly of the dorsal root ganglion-spinal circuit.
The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process.
The results of this study suggest that Prrxl1 knockout mouse model of congenital hypoalgesia may have an effect on brain plasticity that is the inverse of what is usually observed in animal models of chronic pain.
The results of this study showed that Prrxl1(-/-) animal is a valuable model system for examining the genetic assembly and functional role of trigeminal lemniscal circuits in the normal control of eating in mammals.
Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state.
Prrxl1 uses distinct regulatory regions to repress its own expression in dorsal root ganglia and dorsal spinal cord.
Data suggest phosphorylation at serine-119 is a determinant of Prrxl1 conformation/transcriptional activity in embryonic dorsal root ganglia and dorsal spinal cord nociceptive neurons and may regulate Prrxl1 during nociceptive system development.
Prrxl1 transcription is regulated by three alternative promoters, which control the expression of three distinct Prrxl1 5'-UTR variants.
Our present results point to a role for Prrxl1 in sensitization of nociceptive neurons upon inflammatory pain.
Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires Drg11.
transcriptionally regulates DRAGON; coexpressed with DRAGON in embryonic dorsal root ganglion and spinal cord
Our results demonstrate an essential role for Drg11 in the development of the mesencephalic trigeminal nucleus.
DRG11 is required for the establishment of the first neuronal sensory relay along development
Apoptotic cell death is not a sufficient cause of failed pattern formation in the PrV of the DRG11(-/-).
the tissue-specific role of the Prrxl1 gene may be sustained by an accurate balance in the ratio between the amount of Prrxl1 and its OAR-lacking variant, Prrxl1-b, which may be critical during nociceptive circuit development
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity).
dorsal root ganglia homeobox
, paired related homeobox-like 1
, dorsal root ganglion homeobox protein
, dorsal root ganglia homeobox protein
, paired related homeobox protein-like 1
, paired-like homeodomain transcription factor DRG11
, paired-like homeodomain trancription factor DRG11
, dorsal root ganglion 11
, homeobox protein DRG11
, paired-like homeodomain trancription factor Drg11
, paired-related homeobox protein-like 1
, paired homeodomain protein DRG11
, paired related homeobox protein-like 1b