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DCDC2 encodes a doublecortin domain-containing family member. Additionally we are shipping DCDC2 Proteins (5) and many more products for this protein.
Showing 10 out of 97 products:
Human Polyclonal DCDC2 Primary Antibody for IF (p), IHC (p) - ABIN1385734
Choi, de Poot, Lee, Kim, Han, Kim, Finley, Lee: Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. in Nature communications 2016
Mouse (Murine) Polyclonal DCDC2 Primary Antibody for ELISA, WB - ABIN251687
McGrath, Smith, Pennington: Breakthroughs in the search for dyslexia candidate genes. in Trends in molecular medicine 2006
Human Polyclonal DCDC2 Primary Antibody for ELISA, IHC - ABIN251255
Cope, Harold, Hill, Moskvina, Stevenson, Holmans, Owen, ODonovan, Williams: Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. in American journal of human genetics 2005
Human Polyclonal DCDC2 Primary Antibody for ICC, IF - ABIN4304490
Jeruschke, Jeruschke, DiStasio, Karaterzi, Büscher, Nalbant, Klein-Hitpass, Hoyer, Weiss, Stottmann, Weber: Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression. in PLoS ONE 2015
Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages.
Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2
By suggesting the presence of common biological processes underlying reading (dis)ability, these findings represent initial support for a generalist effect of the non-additive interdependence between READ1 and the KIAA0319 (show KIAA0319 Antibodies) risk haplotype and can help in clinically assessing the individual risk for Developmental dyslexia.
Neonatal sclerosing cholangitis patients in substantial proportion harbour mutations in DCDC2.
Study concludes that DCDC2 deletion is not a strong risk factor for dyslexia.
The study corroborates the importance of rs7765678-DCDC2 among others in the aetiology of dyslexia in a German case-control cohort.
Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin (show DCX Antibodies) domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect.
Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect.
that endogenous DYX1C1 (show DYX1C1 Antibodies) localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium
DCDC2 Polymorphism is associated with reading disability.
Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.
Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (show GRIN1 Antibodies) (NMDAR (show GRIN1 Antibodies))
These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin (show DCX Antibodies).
heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
doublecortin domain containing 2
, doublecortin domain-containing protein 2
, doublecortin domain-containing protein 2-like