Dynamin 1-Like (DNM1L) ELISA Kits

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Antibodies (148) and Dynamin 1-Like Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DNM1L 10059 O00429
DNM1L 74006 Q8K1M6
DNM1L 114114 O35303
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Top Dynamin 1-Like ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
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$867.90
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Mouse
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$867.90
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Cow
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$1,029.60
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More ELISA Kits for Dynamin 1-Like Interaction Partners

Human Dynamin 1-Like (DNM1L) interaction partners

  1. cryo-electron microscopy structure of full-length human DRP1 co-assembled with MID49 and an analysis of structure- and disease-based mutations

  2. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release.

  3. knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes.

  4. Results suggest that the loss of dynamin-related protein 1 (Drp1) expression could contribute to the development of lung and colon cancers.

  5. observations indicate that homozygous p.T115M variant of DNM1L produces a neurological and neurodevelopmental phenotype, consistent with impaired mitochondrial architecture and function, through a diminished ability to oligomerize, which was most prevalent under oxidative stress.

  6. Study results reveal a crucial function for Drp1 in regulating tumor growth, mitochondrial morphology, and cell cycle in cutaneous squamous cell carcinoma.

  7. Elimination of Drp1 by shRNA or Mdivi-1 (a Drp1-specific inhibitor) suppressed GBP2's regulatory function. Furthermore, GBP2 blocks Drp1 translocation from the cytosol to mitochondria, thereby attenuating Drp1-dependent mitochondrial fission and breast cancer cell invasion.

  8. hyperacetylation of microtubules contributes to the recruitment of total Drp1 to mitochondria to enhance fission.

  9. Results uncovered a novel mechanism of Drp1-mediated mitochondrial fragmentation in senecionine-induced liver injury.

  10. miR-21-5p/203a-3p promote ox-LDL-induced endothelial senescence through down-regulation of Drp1 in a direct or indirect way.

  11. this study shows that Drp1 can impact survival of epithelial ovarian cancer patients

  12. The structure and function of DNM1L protein in mitochondrial fission is reviewed.

  13. Results described a recessive disease caused by DNM1L mutations, with a clinical phenotype resembling mitochondrial disorders but without any typical biochemical features. Two novel DNM1L mutations (one frame-shift mutation and one missense mutation) are identified and was found to be associated with impaired mitochondrial and peroxisomal morphology.

  14. Study describes mutations in ZNF143 causing a previously undescribed inherited disorder of vitamin B12 (cobalamin) metabolism. These mutations cause an accumulation of transcobalamin-bound cobalamin within the cells, as well as decreased expression of MMACHC, a cobalamin trafficking protein.

  15. The results suggest that endoplasmic reticulum (ER) can function as a platform for Drp1 oligomerization, and that ER-associated Drp1 contributes to mitochondrial division.

  16. PRKAA deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.

  17. hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1

  18. This report describes a patient with a DNM1L mutation and abnormalities in mitochondrial fission and function. The pathogenicity and the dominant nature of the novel p.G362S mutation are demonstrated by overexpression of the mutant gene.

  19. In contrast to the initial report of neonatal lethality resulting from DNM1L mutation and DRP1 dysfunction, our results show that milder DRP1 impairment is compatible with normal early development and subsequently results in a distinct set of neurological findings. In addition, we identify a common pathogenic mechanism whereby DNM1L mutations impair mitochondrial fission.

  20. These findings provide new insights into MCL-1 ligands, and the interplay between DRP-1 and the anti-apoptotic BCL-2 family members in the regulation of apoptosis

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. Data suggest that dynamin-related protein 1 (Drp1) has both membrane constricting and severing abilities and is the dominant dynamin performing mitochondrial and peroxisomal fission.

  2. Authors found a fragmentation of mitochondria due to an increase in mitochondrial fission associated with an up-regulation of dynamin-related protein 1 (Drp1), and a decrease in mitochondrial fusion associated with a down-regulation of mitofusin 2 (Mnf2) and increased proteolysis of optic atrophy 1 (Opa1).

  3. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly.

  4. the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.

  5. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.

  6. his study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model. Our data also suggest that the protective effects of P110 treatment might be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1-dependent p53 mitochondrial translocation.

  7. Drp1 phosphorylation mediated by c-Abl is required for oxidative stress-induced cell death in primary cortical neurons.

  8. Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 activity

  9. Chrysophanol inhibited the LPS-induced production of proinflammatory mediators and cytokines via suppression of mitogen-activated protein kinase/nuclear factor kappa-B activation and reactive oxygen species generation. In addition, chrysophanol downregulated LPS-induced mitochondrial fission by diminishing dynamin-related protein 1 (Drp1) dephosphorylation.

  10. Results uncovered a novel mechanism of Drp1-mediated mitochondrial fragmentation in senecionine-induced liver injury.

  11. Mitophagy and mitochondrial spheroid formation are induced by Drp1-deficiency, resulting in fission impairment.

  12. that laforin and malin are novel regulators of mitochondrial quality control pathway and that the mitochondrial dysfunction resulting from the increased Drp1 levels could underlie neuropathology in Lafora disease

  13. In organ cultures of the first molar, tooth germ developed to the early bell stage. The amount of dentin formed under DRP1 inhibition was significantly larger than that of the control.

  14. Found that X-irradiation triggered Drp1 phosphorylation at serine 616 (S616) but not at serine 637 (S637). Reconstitution analysis revealed that introduction of wild-type (WT) Drp1 recovered radiation-induced mitochondrial fission, which was absent in Drp1-deficient cells.

  15. Findings suggest that a partial reduction of Drp1 decreases the production of phosphorylated Tau, reduces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesis and synaptic activity in Tau mice.

  16. The Drp1 might play a significant role in lamellipodia formation and cell spreading through a different mechanism from that used for regulating mitochondrial dynamics/function.

  17. The structure and function of Dnm1l protein in mitochondrial fission is reviewed.

  18. screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria.

  19. PRKAA deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.

  20. hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA- and dynamin-dependent pathway.

Fruit Fly (Drosophila melanogaster) Dynamin 1-Like (DNM1L) interaction partners

  1. Data show that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan.

  2. Study showed that exogenous expression of Drp1 could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 is involved in the pathogenesis of Alzheimer disease.

  3. Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.

  4. Debcl modulates Drp1 mitochondrial localization during apoptosis.

  5. Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila

  6. functions in the anchoring, unfurling, and elongation of mitochondria during sperm formation

  7. Alterations in both mitochondrial morphology and ATP production caused by either parkin or PINK1 loss of function could be rescued by the mitochondrial fusion proteins Mfn2 and OPA1 or by a dominant negative mutant of the fission protein Drp1.

Dynamin 1-Like (DNM1L) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with Dynamin 1-Like (DNM1L) ELISA Kits

  • dynamin 1 like (DNM1L) antibody
  • dynamin 1-like (Dnm1l) antibody
  • dynamin 1-like L homeolog (dnm1l.L) antibody
  • dynamin 1-like (dnm1l) antibody
  • dynamin-1-like (LOC100369408) antibody
  • dynamin 1 like (dnm1l) antibody
  • dynamin-1-like protein (LOC411472) antibody
  • dynamin-like protein (dyn1) antibody
  • dynamin-like protein (cgd1_580) antibody
  • dynamin-like protein (EHI_052740) antibody
  • dynamin-like protein (PVX_092875) antibody
  • dynamin-like protein (BBOV_II002980) antibody
  • dynamin 1 like (Dnm1l) antibody
  • Dynamin related protein 1 (Drp1) antibody
  • 18.m06247 antibody
  • 6330417M19Rik antibody
  • AI450666 antibody
  • CG3210 antibody
  • Dlp1 antibody
  • Dmel\CG3210 antibody
  • Dnm1/Drp1 antibody
  • DNM1L antibody
  • Dnml1 antibody
  • Dnmlp1 antibody
  • Drp antibody
  • drp-1 antibody
  • drp1 antibody
  • DVLP antibody
  • DYMPLE antibody
  • EMPF antibody
  • frat antibody
  • HDYNIV antibody
  • l(2)22Fc antibody
  • l(2)22Fd antibody
  • l(2)ND2 antibody
  • l(2)ND3 antibody
  • MGC53850 antibody
  • python antibody
  • zgc:66163 antibody

Protein level used designations for Dynamin 1-Like (DNM1L) ELISA Kits

Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-1-like protein , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1 , dynamin 1-like , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , CG3210 gene product from transcript CG3210-RB , CG3210-PA , CG3210-PB , Drp1-PA , Drp1-PB , dynamin related protein-1 , dynamin-2 , dynamin-related protein , dynaminrelated protein 1 , fratboy , lethal(2)22Fc , lethal(2)22Fd , near dpp complementation group 2 , near dpp complementation group 3 , noodle

GENE ID SPECIES
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
477649 Canis lupus familiaris
540892 Bos taurus
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
100728964 Cavia porcellus
33445 Drosophila melanogaster
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