Dynamin 1-Like (DNM1L) ELISA Kits

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Antibodies (119) and Dynamin 1-Like Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DNM1L 10059 O00429
DNM1L 74006 Q8K1M6
DNM1L 114114 O35303
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Top Dynamin 1-Like ELISA Kits at antibodies-online.com

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More ELISA Kits for Dynamin 1-Like Interaction Partners

Human Dynamin 1-Like (DNM1L) interaction partners

  1. The role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs.

  2. succinate promotes DRP1-mediated mitochondrial fission via GPR91, consequently stimulating the hMSC migration through mtROS-induced F-actin formation.

  3. Mitochondrial membrane potential is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn(2+) entry through the Zip1-MCU complex. After division, healthy mitochondria restore MMP levels and participate in the fusion-fission cycle again, but mitochondria that fail to restore MMP undergo mitophagy.

  4. This study suggests that in Huntington's disease, MAPK1 activation leads to the aberrant mitochondrial fission and mitochondrial function by phosphorylating Drp1.

  5. results define the Mst1/Drp1/mitochondrial fission/F-actin axis as a new signaling pathway that mediates LPS-related septic cardiomyopathy by inducing mitochondrial stress and cardiomyocyte death.

  6. Rotavirus nonstructural protein 4 (NSP4) was identified as the viral trigger for disrupted mitochondrial morphology. Severance of mitochondrial interconnections was found to be a dynamin-related protein 1 (Drp1)-dependent process resulting synergistically from augmented mitochondrial fission and attenuated mitochondrial fusion.

  7. 5 patients with pathogenic or likely pathogenic variants of DNM1L were studied, including two novel variants (de novo heterozygous missense mutations, one in the stalk that is lethal (C431Y) and one in the GTPase domain (G32A)). All mutations are at fully conserved regions among all members of the dynamin-related protein family that are involved in membrane division and organelle division events.

  8. This article highlights recent findings in the role of Drp1 in AD pathogenesis. This article also highlights Drp1 and its relationships to glycogen synthase kinase 3, cyclin-dependent kinase 5, p53, and microRNAs in AD pathogenesis.

  9. Glomerular overproduction of Drp1, phospho-Drp1 (Ser 616) and Fis1 occurred mainly in children with membranous nephropathy.

  10. inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions.

  11. cryo-electron microscopy structure of full-length human DRP1 co-assembled with MID49 and an analysis of structure- and disease-based mutations

  12. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release.

  13. knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes.

  14. Results suggest that the loss of dynamin-related protein 1 (Drp1) expression could contribute to the development of lung and colon cancers.

  15. observations indicate that homozygous p.T115M variant of DNM1L produces a neurological and neurodevelopmental phenotype, consistent with impaired mitochondrial architecture and function, through a diminished ability to oligomerize, which was most prevalent under oxidative stress.

  16. Study results reveal a crucial function for Drp1 in regulating tumor growth, mitochondrial morphology, and cell cycle in cutaneous squamous cell carcinoma.

  17. Elimination of Drp1 by shRNA or Mdivi-1 (a Drp1-specific inhibitor) suppressed GBP2's regulatory function. Furthermore, GBP2 blocks Drp1 translocation from the cytosol to mitochondria, thereby attenuating Drp1-dependent mitochondrial fission and breast cancer cell invasion.

  18. hyperacetylation of microtubules contributes to the recruitment of total Drp1 to mitochondria to enhance fission.

  19. Results uncovered a novel mechanism of Drp1-mediated mitochondrial fragmentation in senecionine-induced liver injury.

  20. miR-21-5p/203a-3p promote ox-LDL-induced endothelial senescence through down-regulation of Drp1 in a direct or indirect way.

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. This study demonstrate a role for altered Drp1 mitochondrial fission in the nucleus accumbens, during early cocaine abstinence.

  2. Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enables the normal occurrence of the fission-fusion process.

  3. we provide the first direct evidence that SENP3 upregulation pivotally contributes to myocardial ischemia reperfusion (MIR) injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury.

  4. Our data indicate that the increased vulnerability of the diabetic myocardium to ischemia/reperfusion-induced apoptosis/dysfunction is attributable, in part, to decreased myocardial Sirt1 activity which leads to a decrease in Akt activation, an increase in Drp1 activity, culminating in excessive mitochondrial fission and ROS production.

  5. manipulation of Drp1 hyperactivation might be a useful strategy to develop therapeutics for treating Huntington's disease.

  6. chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle.

  7. Study shows that isoliquiritigenin prevents glutamate-induced mitochondrial fission by inhibiting the dephosphorylation of Drp1 at the serine 637 residue.

  8. results show that a Nestin-Cdk5-Drp1 axis negatively regulates mitochondrial OXPHOS, which is indispensable for the maintenance of NSPC stemness.

  9. Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells

  10. Data establish Drp1 as an important regulator of insulin secretion in vivo and demonstrate a role for Drp1 in metabolic amplification and calcium handling without affecting oxygen consumption.

  11. data indicate that Drp1 is a direct target of Cdk5, and Cdk5-mediated phosphorylation of Drp1 at Serine 579 regulates Abeta1-42 induced mitochondrial fission and neuronal toxicity.

  12. This study performed a systematic analysis of Drp1 transcripts in different mouse tissues and identified a previously uncharacterized isoform that is highly enriched in the brain. This Drp1 isoform is termed Drp1ABCD because it contains four alterative exons: A, B, C, and D. Remarkably, Drp1ABCD is located at lysosomes, late endosomes, and the plasma membrane in addition to mitochondria.

  13. Data suggest that dynamin-related protein 1 (Drp1) has both membrane constricting and severing abilities and is the dominant dynamin performing mitochondrial and peroxisomal fission.

  14. Authors found a fragmentation of mitochondria due to an increase in mitochondrial fission associated with an up-regulation of dynamin-related protein 1 (Drp1), and a decrease in mitochondrial fusion associated with a down-regulation of mitofusin 2 (Mnf2) and increased proteolysis of optic atrophy 1 (Opa1).

  15. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly.

  16. the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.

  17. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.

  18. his study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model. Our data also suggest that the protective effects of P110 treatment might be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1-dependent p53 mitochondrial translocation.

  19. Drp1 phosphorylation mediated by c-Abl is required for oxidative stress-induced cell death in primary cortical neurons.

  20. Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 activity

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA- and dynamin-dependent pathway.

Fruit Fly (Drosophila melanogaster) Dynamin 1-Like (DNM1L) interaction partners

  1. The reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors.

  2. Data show that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan.

  3. Study showed that exogenous expression of Drp1 could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 is involved in the pathogenesis of Alzheimer disease.

  4. Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.

  5. Debcl modulates Drp1 mitochondrial localization during apoptosis.

  6. Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila

  7. functions in the anchoring, unfurling, and elongation of mitochondria during sperm formation

  8. Alterations in both mitochondrial morphology and ATP production caused by either parkin or PINK1 loss of function could be rescued by the mitochondrial fusion proteins Mfn2 and OPA1 or by a dominant negative mutant of the fission protein Drp1.

Dynamin 1-Like (DNM1L) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with Dynamin 1-Like (DNM1L) ELISA Kits

  • dynamin 1 like (DNM1L) antibody
  • dynamin 1-like (Dnm1l) antibody
  • dynamin 1-like L homeolog (dnm1l.L) antibody
  • dynamin 1-like (dnm1l) antibody
  • dynamin-1-like (LOC100369408) antibody
  • dynamin 1 like (dnm1l) antibody
  • dynamin-1-like protein (LOC411472) antibody
  • dynamin-like protein (dyn1) antibody
  • dynamin-like protein (cgd1_580) antibody
  • dynamin-like protein (EHI_052740) antibody
  • dynamin-like protein (PVX_092875) antibody
  • dynamin-like protein (BBOV_II002980) antibody
  • dynamin 1 like (Dnm1l) antibody
  • Dynamin related protein 1 (Drp1) antibody
  • 18.m06247 antibody
  • 6330417M19Rik antibody
  • AI450666 antibody
  • CG3210 antibody
  • Dlp1 antibody
  • Dmel\CG3210 antibody
  • Dnm1/Drp1 antibody
  • DNM1L antibody
  • Dnml1 antibody
  • Dnmlp1 antibody
  • Drp antibody
  • drp-1 antibody
  • drp1 antibody
  • DVLP antibody
  • DYMPLE antibody
  • EMPF antibody
  • frat antibody
  • HDYNIV antibody
  • l(2)22Fc antibody
  • l(2)22Fd antibody
  • l(2)ND2 antibody
  • l(2)ND3 antibody
  • MGC53850 antibody
  • python antibody
  • zgc:66163 antibody

Protein level used designations for Dynamin 1-Like (DNM1L) ELISA Kits

Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-1-like protein , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1 , dynamin 1-like , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , CG3210 gene product from transcript CG3210-RB , CG3210-PA , CG3210-PB , Drp1-PA , Drp1-PB , dynamin related protein-1 , dynamin-2 , dynamin-related protein , dynaminrelated protein 1 , fratboy , lethal(2)22Fc , lethal(2)22Fd , near dpp complementation group 2 , near dpp complementation group 3 , noodle

GENE ID SPECIES
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
477649 Canis lupus familiaris
540892 Bos taurus
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
100728964 Cavia porcellus
33445 Drosophila melanogaster
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