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DNALI1 is the human homolog of the Chlamydomonas inner dynein arm gene, p28.
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Human Polyclonal DNALI1 Primary Antibody for ICC, IF - ABIN4305644
Onoufriadis, Shoemark, Schmidts, Patel, Jimenez, Liu, Thomas, Dixon, Hirst, Rutman, Burgoyne, Williams, Scully, Bolard, Lafitte, Beales, Hogg, Yang, Chung, Emes, OCallaghan, Bouvagnet, Mitchison: Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects. in Human molecular genetics 2014
ADAP coprecipitates with dynein from activated Jurkat cells, and loss of ADAP prevents microtubule-organizing center (MTOC) translocation and the specific recruitment of dynein to the synapse.
Results describe the gene encoding the dynein axonemal light intermediate chain Dnali1, and suggest that the C-terminal part of the cytoplasmic dynein heavy chain 1 (show DYNC1H1 Antibodies) is a putative interacting polypeptide of Dnali1.
Dnali1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects.
dynein, axonemal, light intermediate chain 1
, axonemal dynein light chain
, axonemal dynein light intermediate polypeptide 1
, dJ423B22.5 (axonemal dynein light chain (hp28))
, dynein, axonemal, light intermediate polypeptide 1
, inner dynein arm light chain, axonemal
, inner dynein arm, homolog of clamydomonas
, axonemal dynein light chain (hp28) homolog