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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Additionally we are shipping Dynein, Light Chain, Roadblock Type 2 Proteins (8) and many more products for this protein.
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Human Polyclonal DYNLRB2 Primary Antibody for IHC (p), WB - ABIN654216
Geradts, Groth, Wu, Jin: Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS). in Breast cancer research and treatment 2017
study found that murine leukemia virus (MLV) associates functionally and specifically with the dynein light chain DYNLRB2, which is required for infection; study provides more insight into the molecular requirements for retrograde transport of the MLV preintegration complex and demonstrates a role for DYNLRB2 in viral infection
Among the total 68 liver cancer samples tested, DNLC2B was down-regulated in 28 cases.
Findings indicate that km23-2 (DYNLRB2) is required for Smad3-dependent TGFbeta signaling. Km23-2 has functions in TGFbeta signaling that are distinct from those for km23-1 (DYNLRB1).
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity).
dynein light chain 2B, cytoplasmic
, dynein, cytoplasmic, light chain 2B
, dynein, cytoplasmic, light polypeptide 2B
, bithoraxoid-like protein
, dynein light chain roadblock-type 2
, roadblock domain containing 2
, roadblock domain-containing protein 2