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Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Additionally we are shipping ELF3 Antibodies (130) and many more products for this protein.
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ELF3 controls LCN2 expression in cooperation with NFkappaB.
a novel role for ELF3 (show EFNB3 Proteins) as a procatabolic factor that may contribute to cartilage remodeling and degradation by regulating MMP13 (show MMP13 Proteins) gene transcription.
A novel function of Elf3 (show EFNB3 Proteins) is identified that defines allergic airway inflammation caused by the regulation of dendritic cell-driven T helper (Th)1 (show TH1L Proteins) cell, Th2 cell, and Th17 cell differentiation.
Elf3 (show EFNB3 Proteins) plays an important role in the regulation of lung cell proliferation and differentiation during repair of the injured bronchiolar airway epithelium.
ESE-1 is an Ang II (show AGT Proteins)-inducible transcription factor that plays an important counter-regulatory role in the setting of vascular inflammation and remodeling.
Elf3 (show EFNB3 Proteins) amino acid residues within the flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 (show EFNB1 Proteins) DNA binding and transactivation activity.
Like other Ets (show ETS1 Proteins)-family members, Elf3 (show EFNB3 Proteins) functions as a sequence-specific DNA-binding transcriptional factor
Results reveal that Crif1 (show GADD45GIP1 Proteins) is a novel and essential transcriptional coactivator of Elf3 (show EFNB3 Proteins) for the terminal differentiation of absorptive enterocytes.
Evidence that mElf (show EPM2A Proteins)-3, a member of the Ets (show ETS1 Proteins) family, plays a key role in the activation of the mTbetaR-II promoter.
ErbB2 (show ERBB2 Proteins) activation of ESX gene expression
Data suggest ESE-1 silencing as a mean to treat HER2 (show ERBB2 Proteins)(+) patients who show resistance to anti-HER2 (show ERBB2 Proteins) therapy.
These findings position RIPK4 (show RIPK4 Proteins) upstream of a hierarchal IRF6 (show IRF6 Proteins)-GRHL3 (show GRHL3 Proteins)-ELF3 transcription factor pathway in keratinocytes.
Epithelium-specific ETS transcription factor 1 (ESE1), a member of the Ets transcription factor (show FEV Proteins) family.
ELF3 interacts directly with the HMG domain of Sox9. Importantly, overexpression of ELF3 significantly decreased Sox9/CBP-dependent HAT activity.
Data indicate that the transcription factor E74-like factor 3 (ELF3) was one of the genes whose expression was upregulated in microdissected ovarian cancer cells of long-term survivors.
Survival analysis showed that the non-small cell lung carcinoma patients with enhanced expression of CK7 (show KRT7 Proteins), ELF3, EGFR (show EGFR Proteins), and EphB4 (show EPHB4 Proteins) mRNA in peripheral blood leukocytes had poorer disease-free survival and overall survival than those without.
data suggest that interactions between ESE1 and beta-/alpha-catenins might be a mechanism by which the ESE1 protein determines the beta-catenin (show CTNNB1 Proteins) function and tumorigenesis
ELF3 is a frequently mutated tumor suppressor gene of periampullary tumors.
ELF3 is a novel transcriptional repressor of estrogen receptor alpha (show ESR1 Proteins) in breast cancer cells.
suggest that ESE-1 may play a role in regulating airway inflammation by regulating ICAM-1 (show ICAM1 Proteins) expression
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
E74-like factor 3 (ets domain transcription factor, epithelial-specific)
, ETS-related transcription factor Elf-3
, epithelial-restricted with serine box
, epithelium-restricted Ets protein ESX
, epithelium-specific Ets transcription factor 1
, E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)
, E74-like factor 3 (ets domain transcription factor)
, ets domain transcription factor, serine box (epithelial-specific)