anti-ELOVL Fatty Acid Elongase 4 (ELOVL4) Antibodies

ELOVL4 encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Additionally we are shipping ELOVL4 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ELOVL4 83603 Q9EQC4
ELOVL4 6785 Q9GZR5
ELOVL4 315851  
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Top anti-ELOVL4 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of ELOVL4 expression in HY926 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of ELOVL4 Antibody (C-term) in 293 cell line lysates (35ug/lane). This demonstrates the ELOVL4 antibody detected the ELOVL4 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, using ELOVL4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB ELOVL4 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ELOVL4 antibody detected the ELOVL4 protein (arrow). All lanes : Anti-ELOVL4 Antibody (C-term) at 1:1000 dilution Lane 1: human testis lysate Lane 2: Y79 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis on HeLa cell lysate using ELOVL4 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266897 staining HeLa cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using ELOVL4 antibody (ABIN1872523) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, WB 10 blots Log in to see 11 to 14 Days
$654.50
Details
Human Rabbit Un-conjugated ELISA, WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 14 Days
$375.83
Details

Top referenced anti-ELOVL4 Antibodies

  1. Human Polyclonal ELOVL4 Primary Antibody for WB - ABIN550372 : Vasireddy, Uchida, Salem, Kim, Mandal, Reddy, Bodepudi, Alderson, Brown, Hama, Dlugosz, Elias, Holleran, Ayyagari: Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. in Human molecular genetics 2007 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ELOVL4 Interaction Partners

Mouse (Murine) ELOVL Fatty Acid Elongase 4 (ELOVL4) interaction partners

  1. these studies establish a critical, novel role for ELOVL4 and its VLC-SFA products in regulating synaptic release kinetics and epileptogenesis.

  2. The abnormal presence of ELOVL4 protein in POSs results in phagosomes that are defective in recruiting appropriate motor protein linkers, thus contributing to slower degradation because their altered motility results in slower basal migration and fewer productive encounters with endolysosomes.

  3. ELOVL4 is significantly reduced in the diabetic retina.

  4. mutations in the ELOVL4 gene lead to cone degeneration in humans, whereas mouse models expressing the mutant Elovl4 show predominant rod degeneration

  5. Studies indicate that Knock-IN and Knock-OUT strains of ELOVL4 (STGD3) model development has been to unveil the causal connection between the genotype and early-onset progressive cone degeneration in humans.

  6. ELOVL4 enzymatic activity is governed by individual histidines in its active site and the endoplasmic reticulum microenvironment.

  7. To elucidate the role of VLC-PUFAs in photoreceptor terminals, we conditionally deleted Elovl4 in rod and cone photoreceptors of mice and measured inner retina function, synaptic connectivity, and ultrastructure of rod terminals with reduced VLC-PUFAs.

  8. expression and outer segment mislocalization of the disease-linked 5-base-pair deletion mutant ELOVL4 protein alters photoreceptor structure and function

  9. The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of very long chain-PUFA in the retinal phosphatidylcholine (PC) fraction compared to retinas from wild-type mice.

  10. ELOVL4 was strongly expressed within the holocrine meibomian and sebaceous glands but no ELOVL4 was detected within the central meibomian duct.

  11. the presence of the mutant ELOVL4 does not affect the function of wild-type ELOVL4 in the fully developed 8- to 10-week-old retinas.

  12. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.

  13. the critical role of Elovl4 for proper rod or cone photoreceptor function

  14. Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice.

  15. ELOVL4 protein is not involved in docosahexaenoic acid biosynthesis from the short chain fatty acid precursors 18:3n3 and 22:5n3.

  16. deficit leads to the human STGD3 pathology.

  17. The ELOVL4 gene is highly conserved throughout evolution and is expressed in the photoreceptor cells of the retina in a variety of different species

  18. Elovl4 expression in developing retina follows a dynamic pattern. It switches from predominant ganglion cell expression in embryonic and early postnatal development to predominant expression in the photoreceptor inner segments

  19. ELOVL4 may play an important role in embryonic development and in maintaining normal physiology of retina and brain at later stages of development

  20. These findings demonstrate that ELOVL4 is required for generating very long-chain fatty acids critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment.

Human ELOVL Fatty Acid Elongase 4 (ELOVL4) interaction partners

  1. A highly reduced activity of the ELOVL4 promoter was registered due to combination of two variants. Decrease of ELOVL4 enzymatic activity could lead to a deficiency of VLC-PUFA, essential components for rods function and longevity, which are among the parameters involved in the etiopathogenesis of stargardt disease.

  2. Normalization of retinal ELOVL4 expression could prevent blood-retinal barrier dysregulation in diabetic retinopathy through an increase in very long-chain ceramides and stabilization of tight junctions.

  3. Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene

  4. In the control group, four different genetic variations were detected in ELOVL4, and five in PRPH2. STGD patients of different ethnicities may carry distinct ELOVL4 and PRPH2 sequence variants. We believe that the genetic variations identified in this study may be related to STGD etiopathogenesis.

  5. In patients with intrahepatic cholestasis of pregnancy, there was no elevation in ELOVL4 mRNA in maternal circulation compared with controls.

  6. Both ELOVL4- and PROM1-related maculopathies are characterized by progressive photoreceptor atrophy and central vision loss. Using advanced diagnostic imaging, early disease changes and disease progression can be characterized.

  7. different mutations in ELOVL4 can cause variable phenotypic neurological disorders (Review)

  8. Spinocerebellar ataxia was associated with a novel mutation in ELOVL4 in a large family pedigree.

  9. In this review, we summarize our current understanding of the disease-causing mutation and its potential role in STGD3 pathogenesis.

  10. We propose that transgenic expression of ELOVL4 in the liver will result in the biosynthesis of very long chain-PUFA that can be transported to target.

  11. ELOVL4 is identified as the causative gene for erythrokeratodermia variabilis and spinocerebellar ataxia in a French-Canadian family.

  12. A novel homozygous nonsense mutation in ELOVL4 cuases a neuro-ichthyotic disorder with variable expressivity.

  13. Coexpression of different forms of wild-type and mutant ELOVL4 revealed a large dominant-negative effect of mutant protein on ELOVL4 localization and enzymatic activity, resulting in reduced VLC-PUFA synthesis.

  14. 5 single nucleotide polymorphisms (SNPs: rs3812153, rs7764439, rs390659, rs434102 and c:929G>A) were detected in ELOVL4.

  15. Mutation in ELOVL4 gene is associated with Stargardt Disease.

  16. recessive mutations in ELOVL4 as the cause of a neuro-ichthyotic disease

  17. Not only the ELOVL4-ELOVL4DeltaC homo-oligomeric interaction, but also several hetero-oligomeric interactions, may contribute to the pathology of Stargardt disease 3.

  18. There was no association between the M299V variant in ELOVL4 gene and exudative age-related macular degeneration in a Chinese population.

  19. Pathogenic mutations found in the ELOVL4 gene result in altered trafficking of the protein and behave with a dominant negative effect.

  20. Recessive retinitis pigmentosa and Leber congenital amaurosis are rarely if ever associated with changes in the ELOVL4 gene.

ELOVL4 Antigen Profile

Protein Summary

This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration.

Gene names and symbols associated with ELOVL4

  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ002114) antibody
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ003687) antibody
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ011025) antibody
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ013819) antibody
  • ELOVL fatty acid elongase 4 (ELOVL4) antibody
  • elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 (elovl4) antibody
  • elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 (Elovl4) antibody
  • ELOVL fatty acid elongase 4 (Elovl4) antibody
  • ADMD antibody
  • CT118 antibody
  • elovl4 antibody
  • ISQMR antibody
  • MGC122553 antibody
  • STGD2 antibody
  • STGD3 antibody

Protein level used designations for ELOVL4

elongation of very long chain fatty acids protein 4 , elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 , elongation of very long chain fatty acids family member protein 4 , ELOVL fatty acid elongase 4 , 3-keto acyl-CoA synthase Elovl4 , ELOVL FA elongase 4 , very-long-chain 3-oxoacyl-CoA synthase 4 , 3-keto acyl-CoA synthase ELOVL4 , Stargardt disease 3 (autosomal dominant) , cancer/testis antigen 118 , elongation of very long chain fatty acids-like 4 , elongation of very long chain fatty acids 4

GENE ID SPECIES
6032855 Culex quinquefasciatus
6035294 Culex quinquefasciatus
6043662 Culex quinquefasciatus
6046870 Culex quinquefasciatus
421850 Gallus gallus
462842 Pan troglodytes
481894 Canis lupus familiaris
100124726 Xenopus (Silurana) tropicalis
100596130 Nomascus leucogenys
83603 Mus musculus
6785 Homo sapiens
315851 Rattus norvegicus
692070 Macaca mulatta
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